Cytidine Diphosphate Diglycerides (CDP-Diacylglycerol)

The ester of diacylglycerol with the terminal phosphate of cytidine diphosphate. It serves as an intermediate in the biosynthesis of phosphatidylethanolamine and phosphatidylserine in bacteria.

Also Known As:

CDP-Diacylglycerol; CDP Diacylglycerol; Diacylglycerols, CDP; Diglycerides, CDP; Diglycerides, Cytidine Diphosphate; Diphosphate Diglycerides, Cytidine; Diphosphodiacylglycerols, Cytidine; CDP Diacylglycerols; CDP Diglycerides; Cytidine Diphosphodiacylglycerols

Networked: 10 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Gui, Jiang: 1 article (06/2022)
2.	Karagas, Margaret R: 1 article (06/2022)
3.	Madan, Juliette: 1 article (06/2022)
4.	Moroishi, Yuka: 1 article (06/2022)
5.	Morrison, Hilary G: 1 article (06/2022)
6.	Nadeau, Kari C: 1 article (06/2022)
7.	Davis, Ian C: 1 article (01/2021)
8.	Doolittle, Lauren M: 1 article (01/2021)
9.	El-Musa, Hasan: 1 article (01/2021)
10.	Hickman-Davis, Judy M: 1 article (01/2021)

Related Diseases

1.	Neuroblastoma 02/01/1996 - "Inhibition of neuroblastoma cell phosphatidylinositol 3-kinase by CDP-diacylglycerol and phosphatidate." 04/01/1993 - "Lithium enhances muscarinic receptor-stimulated CDP-diacylglycerol formation in inositol-depleted SK-N-SH neuroblastoma cells." 04/01/1993 - "In the present study, the effect of Li+ on muscarinic receptor-stimulated formation of the immediate precursor of phosphatidylinositol, CDP-diacylglycerol (CDP-DAG), has been examined in human SK-N-SH neuroblastoma cells that have been cultured under conditions that alter the cellular content of myo-inositol. "
2.	Infections 01/01/2021 - "Daily coadministration of CDP-diacylglycerol significantly enhanced the beneficial effects of CDP-choline and also modified the ATII cell lipidome, reversing the infection-induced decrease in phosphatidylcholine and increasing concentrations of most other lipid classes in ATII cells. " 11/01/2009 - "This study reports that Escherichia coli phosphatidylcholine-positive (PC+) strain Top10/ptac66 (PC+ PE+), in which borrelial PC synthase (PCS) directly condenses exogenous choline with CDP-diacylglycerol (CDP-DAG) to form PC, displayed not only stronger resistance to antimicrobial peptides cecropin P1 and indolicidin, but also decreased ability to attract macrophages to the abdominal cavity of infected mice in the 36 h following infection, compared with the control strain Top10/ptac85 (PC- PE+). "
3.	Tetanus 01/01/2023 - "Metagenomics analyses identified species and metabolic pathways in 6-week stool associated with tetanus antibody response, in particular, negative associations with the relative abundance of Aeriscardovia aeriphila species and positive associations with the relative abundance of species associated with CDP-diacylglycerol biosynthesis pathways. "
4.	Pulmonary Alveolar Proteinosis 04/28/1989 - "These changes in the acidic phospholipids in BAL fluids of patients with pulmonary alveolar proteinosis appear to indicate that a switch-over in the synthesis of both acidic phospholipids from a same precursor CDP-diacylglycerol (CDP-DG) in alveolar Type II cells occurs in a such diseased state. "
5.	Neoplasms (Cancer) 07/01/1978 - "Mitochondria in this poorly differentiated tumor are the principal sites of CDP-diacylglycerol synthesis, in contrast to normal rat liver where the endoplasmic reticulum is most active. "

Related Drugs and Biologics

1.	Cytidine Diphosphate (CDP)
2.	Phosphatidylinositols (Phosphatidylinositol)
3.	Phosphatidylcholines (Phosphatidylcholine)
4.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
5.	Inositol (Myoinositol)
6.	Choline (Choline Chloride)
7.	Antimicrobial Peptides
8.	indolicidin
9.	cecropin P1-LI
10.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)