|1.||Adibhatla, Rao Muralikrishna: 9 articles (03/2013 - 01/2002)|
|2.||Secades, Julio J: 8 articles (07/2012 - 12/2002)|
|3.||Cansev, Mehmet: 7 articles (02/2016 - 05/2003)|
|4.||Savci, Vahide: 7 articles (04/2015 - 05/2002)|
|5.||Castillo, José: 7 articles (01/2013 - 12/2002)|
|6.||Hatcher, J F: 7 articles (10/2005 - 12/2000)|
|7.||Bekar, Ahmet: 5 articles (02/2016 - 12/2007)|
|8.||Parisi, Vincenzo: 5 articles (08/2015 - 01/2005)|
|9.||Díez-Tejedor, Exuperio: 5 articles (09/2012 - 09/2006)|
|10.||Dávalos, Antoni: 5 articles (07/2012 - 12/2002)|
11/01/2013 - "Citicoline in the treatment of acute ischaemic stroke: an international, randomized, multicentre, placebo-controlled study (ICTUS trial) is the use of Citicoline is beneficial for acute ischaemic stroke?"
01/01/2011 - "A recent trial lasting 6 months in patients with first-ever ischemic stroke showed that citicoline prevented cognitive decline after stroke with significant improvement of temporal orientation, attention, and executive function. "
09/01/2012 - "From these results, we conclude that high-dose CDP-choline may be an effective treatment for acute ischaemic stroke even in absence of thrombolysis."
09/01/2012 - "CDP-choline at high doses is as effective as i.v. thrombolysis in experimental animal stroke."
04/01/2009 - "Oral citicoline improved neurological, functional and global outcomes in patients with acute ischemic stroke without significant safety concerns."
|2.||Brain Ischemia (Cerebral Ischemia)
12/29/2010 - "CDP-Choline in MLCDP delivery system was found potent to exert substantial protection against global moderate cerebral ischemia reperfusion induced mitochondrial damage in aged rat brain. "
03/01/2005 - "The present study was designed to search for mechanisms of citicoline neuroprotective properties using in vivo and in vitro models of brain ischemia. "
09/01/2013 - "CDP-choline has shown neuroprotective effects in cerebral ischemia. "
01/01/2013 - "We also describe the development of anti-HSP72 vectorized stealth immunoliposomes containing imaging probes to make them traceable by conventional imaging techniques (fluorescence and MRI) that were used to encapsulate a therapeutic agent (citicoline) for the treatment of cerebral ischemia. "
01/01/2011 - "These results suggest that CDP-choline has ameliorative effects on the impairment of spatial memory via hippocampal neuronal cell death in a rat model of cerebral ischemia."
12/01/2014 - "In the current study, we determined the effect of intravenously administered CDP-choline on myocardial tissue injury induced by 30-min ischemia followed by 3-h reperfusion in anesthetized rats. "
12/01/2014 - "Protective effect of CDP-choline on ischemia-reperfusion-induced myocardial tissue injury in rats."
09/01/2011 - "This MRI-guided stereotactic delivery of citicoline resulted in a notable reduction (>80%) in infarct size and a delayed ischemic injury in cortex 12 hours after onset of acute ischemia when compared with the systematic delivery. "
06/01/2010 - "A 600 mmol/kg dose of citicoline was given intraperitoneally before ischemia in the citicoline and postconditioning citicoline groups. "
01/01/2008 - "Infarct volume measured at 48 h after ischemia showed a reduction in the group treated with CDP-choline 4 h after occlusion. "
|4.||Brain Injuries (Brain Injury)
03/01/1999 - "Consequently, Citicoline may potentially be very helpful for patients suffering traumatic brain injuries and should, in our opinion, be made available and studied further in this clinical population."
04/01/2003 - "Treating rats with CDP-choline (200 and 400 mg/kg, intraperitoneally) significantly prevented TBI-induced neuronal loss in the hippocampus, decreased cortical contusion volume, and improved neurological recovery. "
11/21/2012 - "Among patients with traumatic brain injury, the use of citicoline compared with placebo for 90 days did not result in improvement in functional and cognitive status. "
07/01/2015 - "We examined the influence of the (C/T) SNP rs1800497 of ANKK1 on post-TBI outcome using data from two prospective multicenter studies: the Citicoline Brain Injury Treatment (COBRIT) trial and Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot). "
11/21/2012 - "The Citicoline Brain Injury Treatment Trial (COBRIT), a phase 3, double-blind randomized clinical trial conducted between July 20, 2007, and February 4, 2011, among 1213 patients at 8 US level 1 trauma centers to investigate effects of citicoline vs placebo in patients with TBI classified as complicated mild, moderate, or severe. "
10/01/2002 - "Citicoline could be effective in the treatment of MCI, although more studies are needed in order to check whether the effect continues in the long term and whether it manages to slow down the progression to dementia."
05/01/1996 - "Citicoline may prove effective in treating age-related cognitive decline that may be the precursor of dementia."
09/01/1994 - "The number of the pass-tasks in CCCE increased significantly after the 7 days-injection of CDP-choline only in the VD group (p < 0.05), while it was fairly stable in 15 control patients, who were matched in age and severity of dementia to the study patients. "
05/01/2015 - "To assess the conditions of use of citicoline in the Health Area of Tenerife, in order to detect deviations from the indications of use as stipulated in the prescribing information sheet and the pattern of prescription, with emphasis on the analysis of its use in dementia where currently it has no indication or evidence to support it. "
10/01/2002 - "Likewise, citicoline has been shown to improve memory and other cognitive functions in patients with chronic cerebrovascular disease or dementia and in old people suffering from memory deficit without dementia. "
|1.||Cytidine Diphosphate Choline (Citicoline)
|2.||Choline (Choline Chloride)
|6.||Cocaine (Cocaine HCl)
|7.||Glutathione (Reduced Glutathione)
|8.||Tissue Plasminogen Activator (Alteplase)
|10.||Antipsychotic Agents (Antipsychotics)