Cystine (L-Cystine)

02/01/2019 - "Our ongoing studies indicate that cystine diamides are effective in preventing cystine stone formation in the Slc3a1 knockout mouse model for cystinuria. "
10/11/2023 - "A total of 10 patients with cystinuria diagnosed with cystine stones in a single tertiary medical center (Severance Hospital, Seoul, Republic of Korea) from April 2000 to July 2023 were included in the study. "
12/01/2022 - "The goal of this study was to validate a novel high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method for quantification of cystine in the urine of patients with cystinuria receiving a CBTD. "
06/01/1996 - "Genetic linkage analysis with markers of the genomic region of rBAT in chromosome 2 (G band 2p16.3) and intragenic markers of rBAT have demonstrated genetic heterogeneity for cystinuria; the rBAT gene is linked to type I cystinuria, but not to type III. Biochemical, genetic and clinical studies are needed to identify the additional cystinuria genes; a low-affinity cystine reabsortion system and the putative light subunit of rBAT are additional candidate genes for cystinuria. "
11/13/2023 - "Cystinuria treatment may require a combined approach of high diuresis, alkalinization and pharmacological interventions with regular monitoring of urinary pH, cystine levels, cystine crystal volume and solubility. "

01/09/2023 - "Currently, elevated white blood cell (WBC) cystine content is the gold standard for the diagnosis of cystinosis. "
12/21/2021 - "All of these models have helped shape our understanding of cystinosis and have led to the conclusion that cystine accumulation is not the only pathology that needs targeting in this multisystemic disease. "
03/01/2023 - "The purpose of this study was to assess the suitability of corneal densitometry measurements obtained with Scheimpflug imaging in estimating the corneal changes caused by cystine deposits in the cornea in patients with cystinosis. "
08/01/2021 - "GoldinLenses of this study can be used for drugless cystine removal cystinosis treatment with one- or five-hour wear at a time."
03/01/2021 - "The purpose of the present study was to establish a semi-automated threshold-based image segmentation algorithm to detect and objectively quantify corneal cystine crystal deposition in ocular cystinosis with anterior segment optical coherence tomography (AS-OCT). "

01/01/2019 - "Our recent study identified the cystine transporter solute carrier family 7 member 11 (SLC7A11) as a critical BAP1 target, and showed that BAP1 promotes ferroptosis (a non-apoptotic cell death) through repressing SLC7A11 expression, resulting in tumor suppression."
10/01/2023 - "Lysosomal cystine controls ferroptosis in cancer."
01/01/2023 - "The cystine transporter solute carrier family 7 member 11 (SLC7A11; also called xCT) protects cancer cells from oxidative stress and is overexpressed in many cancers. "
01/01/2023 - "Disulfidopathy, a novel cystine-associated programmed cell death, plays complex roles in various tumors. "
01/01/2023 - "In contrast, cystine uptake and metabolism to downstream metabolites was a universal feature of normal tissues and tumors. "

01/01/2006 - "In this study, we reviewed cystine calculi cases in the west of Iran to determine their common presentations and response to different therapeutic modalities. "
01/01/2006 - "Pediatric cystine calculi in west of Iran: a study of 22 cases."
12/01/1992 - "To study the radiopacity of cystine calculi. "
06/01/1992 - "Ultrastructural studies have provided further insight into the structure and composition of cystine calculi. "
06/01/1992 - "[Cystine calculi: x-ray diffraction study. "

11/01/2004 - "11 patients with recurrent cystine calculosis and 15 healthy volunteers participated in the study. "
12/01/2000 - "[Cystine lithiasis: study of a series of 116 cases]."
01/01/1972 - "[Clinical studies on 3 cases of cystine calculosis]."
10/01/1967 - "[Study of the urine in cystine lithiasis. "
10/01/2022 - "Patients present hyperexcretion of cystine in the urine, recurrent cystine lithiasis, and progressive decline in kidney function. "