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Cystic Fibrosis (Mucoviscidosis)

An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
Also Known As:
Mucoviscidosis; Fibrocystic Disease of Pancreas; Pancreatic Cystic Fibrosis; Pulmonary Cystic Fibrosis; Cystic Fibrosis, Pancreatic; Cystic Fibrosis, Pulmonary; Fibrosis, Cystic; Pancreas Fibrocystic Disease; Pancreas Fibrocystic Diseases
Networked: 12969 relevant articles (552 outcomes, 1327 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Infection
2. Lung Diseases (Lung Disease)
3. Bronchiectasis
4. Asthma (Bronchial Asthma)
5. Chronic Obstructive Pulmonary Disease (COPD)

Experts

1. Ratjen, Felix: 63 articles (11/2015 - 02/2002)
2. Konstan, Michael W: 48 articles (11/2015 - 05/2002)
3. Elborn, J Stuart: 41 articles (12/2015 - 09/2003)
4. McElvaney, Noel G: 36 articles (12/2015 - 06/2003)
5. Boucher, Richard C: 35 articles (12/2015 - 02/2002)
6. Zeitlin, Pamela L: 35 articles (01/2015 - 03/2002)
7. Amaral, Margarida D: 34 articles (11/2015 - 09/2002)
8. Greene, Catherine M: 32 articles (12/2015 - 06/2003)
9. Accurso, Frank J: 32 articles (11/2015 - 03/2002)
10. Becq, Frédéric: 31 articles (10/2015 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cystic Fibrosis:
1. Tobramycin (Nebcin)FDA LinkGeneric
2. Anti-Bacterial Agents (Antibiotics)IBA
3. human DNASE1 protein (dornase alfa)FDA Link
4. Azithromycin (Zithromax)FDA LinkGeneric
5. Ceftazidime (Fortum)FDA LinkGeneric
6. DNA (Deoxyribonucleic Acid)IBA
7. Ciprofloxacin (Cipro)FDA LinkGeneric
8. Diffuse panbronchiolitisIBA
9. Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
10. Mannitol (Osmitrol)FDA LinkGeneric

Therapies and Procedures

1. Lung Transplantation
2. Microspheres (Microsphere)
3. Transplants (Transplant)
4. Drug Therapy (Chemotherapy)
5. Nebulizers and Vaporizers (Inhaler)