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Cystathionine beta-Synthase (Serine Sulfhydrase)

A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyzes the reaction of homocysteine with serine to form cystathionine with the elimination of water. Deficiency of this enzyme leads to HYPERHOMOCYSTEINEMIA and HOMOCYSTINURIA. EC 4.2.1.22.
Also Known As:
Serine Sulfhydrase; Cystathionine Synthetase; Cystathionine beta Synthase; Sulfhydrase, Serine; Synthetase, Cystathionine; beta Thionase; beta-Synthase, Cystathionine; beta-Thionase; L-Serine hydro-lyase (adding homocysteine)
Networked: 455 relevant articles (5 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Janel, Nathalie: 24 articles (01/2022 - 03/2003)
2. Kraus, Jan P: 19 articles (05/2018 - 06/2002)
3. Kruger, Warren D: 16 articles (07/2022 - 08/2005)
4. Paul, Jean-Louis: 14 articles (01/2022 - 01/2007)
5. Stabler, Sally P: 12 articles (01/2021 - 02/2002)
6. Delabar, Jean-Maurice: 12 articles (02/2015 - 05/2005)
7. Allen, Robert H: 11 articles (01/2017 - 02/2002)
8. Kožich, Viktor: 10 articles (01/2022 - 10/2010)
9. Gupta, Sapna: 10 articles (01/2019 - 08/2008)
10. Hamelet, Julien: 10 articles (08/2009 - 08/2006)

Related Diseases

1. Homocystinuria
2. Hyperhomocysteinemia
3. Pyridoxine-Responsive Homocystinuria
4. Thromboembolism
5. Colonic Neoplasms (Colon Cancer)

Related Drugs and Biologics

1. Prodrugs
2. Aminooxyacetic Acid
3. Homocysteine
4. Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)
5. Enzymes
6. 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (Methyltetrahydrofolate Homocysteine Methyltransferase)
7. Methionine (L-Methionine)
8. Folic Acid (Vitamin M)
9. Oxidoreductases (Dehydrogenase)
10. Cystathionine gamma-Lyase (Cysteine Desulfhydrase)

Related Therapies and Procedures

1. Therapeutics
2. Castration
3. Enzyme Replacement Therapy
4. Endarterectomy (Thromboendarterectomy)