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Cystathionine beta-Synthase (Serine Sulfhydrase)

A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyzes the reaction of homocysteine with serine to form cystathionine with the elimination of water. Deficiency of this enzyme leads to HYPERHOMOCYSTEINEMIA and HOMOCYSTINURIA. EC 4.2.1.22.
Also Known As:
Serine Sulfhydrase; Cystathionine Synthetase; Cystathionine beta Synthase; Sulfhydrase, Serine; Synthetase, Cystathionine; beta Thionase; beta-Synthase, Cystathionine; beta-Thionase; L-Serine hydro-lyase (adding homocysteine)
Networked: 435 relevant articles (4 outcomes, 35 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Janel, Nathalie: 21 articles (02/2015 - 03/2003)
2. Kraus, Jan P: 13 articles (01/2013 - 06/2002)
3. Delabar, Jean-Maurice: 12 articles (02/2015 - 05/2005)
4. Paul, Jean-Louis: 11 articles (02/2015 - 01/2007)
5. Kruger, Warren D: 11 articles (08/2013 - 03/2004)
6. Hamelet, Julien: 10 articles (08/2009 - 08/2006)
7. Allen, Robert H: 9 articles (01/2015 - 02/2002)
8. Stabler, Sally P: 9 articles (01/2015 - 02/2002)
9. Noll, Christophe: 8 articles (04/2013 - 08/2007)
10. Kozich, Viktor: 8 articles (07/2010 - 06/2002)

Related Diseases

1. Homocystinuria
2. Hyperhomocysteinemia
3. Thromboembolism
4. Vascular Diseases (Vascular Disease)
5. Down Syndrome (Down's Syndrome)

Related Drugs and Biologics

1. Pyridoxine (Pyridoxin)
2. Homocysteine
3. Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)
4. Methionine (L-Methionine)
5. Enzymes
6. Folic Acid (Vitamin M)
7. 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (Methyltetrahydrofolate Homocysteine Methyltransferase)
8. Cystathionine gamma-Lyase (Cysteine Desulfhydrase)
9. Oxidoreductases
10. Vitamins

Related Therapies and Procedures

1. Castration
2. Endarterectomy (Thromboendarterectomy)