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Adenoid Cystic Carcinoma (Cylindroma)

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Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)

Also Known As:

Cylindroma; Carcinoma, Adenoid Cystic; Adenoid Cystic Carcinomas; Carcinomas, Adenoid Cystic; Cylindromas; Cystic Carcinoma, Adenoid; Cystic Carcinomas, Adenoid

Networked: 711 relevant articles (24 outcomes, 104 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Neoplasms: 431835
- Neoplasms by Histologic Type: 1
  - Glandular and Epithelial Neoplasms: 260
    - Carcinoma: 95815
      - Adenocarcinoma: 28240
        Adenoid Cystic Carcinoma: 711

Related Diseases

1.	Neoplasm Metastasis (Metastasis)
2.	Neoplasms (Cancer)
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma)
4.	Pleomorphic Adenoma
5.	Adenocarcinoma

Experts

1.	Wang, Jie: 7 articles (01/2010 - 09/2003)
2.	Zhou, Xiao-jian: 6 articles (01/2010 - 06/2003)
3.	Araújo, V C: 6 articles (10/2004 - 08/2000)
4.	Li, Jiang: 5 articles (12/2009 - 07/2006)
5.	Zhang, Zhi-yuan: 4 articles (01/2010 - 07/2006)
6.	Wang, Xu: 4 articles (01/2010 - 01/2006)
7.	Tian, Zhen: 4 articles (12/2009 - 07/2006)
8.	Peng, Bin: 4 articles (04/2009 - 10/2005)
9.	Zhong, Ming: 4 articles (04/2008 - 02/2005)
10.	Ma, Jie: 4 articles (04/2008 - 02/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Adenoid Cystic Carcinoma:

1.	Cisplatin (Platino)FDA LinkGeneric 07/01/1997 - "This cisplatin/5-FU regimen would appear to produce a low rate of objective response but useful palliative benefits in advanced symptomatic adenoid cystic carcinoma. " 04/01/1982 - "Intra-arterial cisplatin treatment of adenoid cystic carcinoma." 12/01/1981 - "Cisplatin therapy for adenoid cystic carcinoma." 09/01/1981 - "[Intraarterial therapy of maxillary adenoid cystic carcinoma using cis-platinum (author's transl)]" 07/01/1992 - "Cisplatin-based chemotherapy in advanced adenoid cystic carcinoma of the head and neck." Order ALL the reference details at left...
2.	Doxorubicin (Adriamycin)FDA LinkGeneric 05/01/1979 - "Partial remission of advanced adenoid cystic carcinoma obtained with adriamycin: a case report with a review of the literature." 05/01/1979 - "We achieved a partial remission with adriamycin in a patient with advanced metastases of adenoid cystic carcinoma. " 06/01/1989 - "Multiple metastatic lesions of adenoid cystic carcinoma of the skin completely regressed after two courses of the combination chemotherapy with cisplatin and adriamycin. " 08/01/1982 - "Two months after a complete response to doxorubicin hydrochloride and cyclophosphamide administered for systemic effects, with the disappearance of pulmonary and pleural metastases from adenoid cystic carcinoma of salivary origin, a patient experienced symptomatic choroidal metastasis with no other evidence of active disease. " 07/01/1992 - "Nineteen patients, nine men and 10 women, with advanced adenoid cystic carcinoma (ACC), were treated with cisplatin either alone or in combination with doxorubicin and bleomycin. " Order ALL the reference details at left...
3.	Fluorouracil (Carac)FDA LinkGeneric 06/01/1964 - "INFUSION OF 5-FLUOROURACIL IN CYLINDROMA TREATMENT." 07/01/1997 - "Cisplatin and 5-fluorouracil for symptom control in advanced salivary adenoid cystic carcinoma." 03/01/2009 - "Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma." 03/01/2009 - "The present study aimed to evaluate the growth-inhibitory effect of sulforaphane (SFN) and a traditional chemotherapy agent, 5-fluorouracil (5-Fu), against the proliferation of salivary gland adenoid cystic carcinoma high metastatic cell line (ACC-M) and low metastasis cell line (ACC-2). " 01/01/2001 - "Locally recurrent adenoid cystic carcinoma of the left antrum: response to epirubicin, cisplatin and 5-fluorouracil." Order ALL the reference details at left...
4.	PeplomycinIBA 06/01/1989 - "This report showed that cisplatin combination chemotherapy may be useful for the treatment of cutaneous squamous cell carcinoma, which is resistant to peplomycin, and adenoid cystic carcinoma of the skin." Order ALL the reference details at left...
5.	titanium silicide (TS-1)IBA 07/01/2004 - "It was indicated that TS-1 may be effective in the treatment of multiple pulmonary metastases of adenoid cystic carcinoma." Order ALL the reference details at left...
6.	FAP protocolIBA 01/01/1994 - "[Efficacy of the combination of 5 fluorouracil, adriamycin and cisplatin (FAP protocol) in the treatment of metastatic cylindroma. " Order ALL the reference details at left...
7.	DNA (Deoxyribonucleic Acid)IBA 09/01/2009 - "This study aimed to identify the potential role of inhibiting DNA binding-1 (Id-1) in human salivary adenoid cystic carcinoma (SACC) progression. " 11/01/2004 - "OBJECTIVE: To study the correlation between flow cytometrically measured DNA ploidy with prognostically important histopathologic groups and clinical outcome in patients with adenoid cystic carcinoma of the salivary glands. " 10/01/2002 - "Adenoid cystic carcinoma of the trachea and bronchus--a clinicopathologic study with DNA flow cytometric analysis and oncogene expression." 01/01/1999 - "However, in situ DNA hybridization and polymerase chain reaction in our current study failed to demonstrate the existence of HPV DNA in adenoid cystic carcinoma." 04/01/1998 - "DNA analysis at p53 locus in adenoid cystic carcinoma: comparison of molecular study and p53 immunostaining." Order ALL the reference details at left...
8.	CollagenIBA 05/01/1997 - "Adenoid cystic carcinoma of the breast: utility of immunocytochemical study with collagen IV on fine-needle aspiration." 05/01/1991 - "These results suggest that cylindroma can be used as an abundant source to produce collagen VII in vitro to study the biosynthesis and regulation of collagen VII and the formation of the anchoring fibrils, as other culture systems have failed to produce ample amounts of this anchoring fibril protein." 02/01/2007 - "Establishment and characterization of a human adenoid cystic carcinoma cell line forming colonies cultured in collagen gel and transplantable in nude mice." 01/01/2005 - "As reported for other BM components, the expressions of the alpha1 (IV) and alpha5 (IV) collagen chains are altered in the BM-like zone surrounding the epithelial clumps in cylindromas. " 01/01/2005 - "Distinct expression patterns of alpha1 (IV) and alpha5 (IV) collagen chains in cylindroma and malignant cylindroma." Order ALL the reference details at left...
9.	polylactic acid-polyglycolic acid copolymer (PLGA)IBA 03/01/2006 - "PLGA shares histological features with adenoid cystic carcinoma (ACC), including infiltrating solid and cribriform patterns, presence of cystic spaces, and neurotropism. " 01/01/1990 - "Although previous reports have emphasized the histologic similarities of PLGA and adenoid cystic carcinoma, our findings indicate that differentiation of PLGA from BPA may represent a more common diagnostic problem. " 06/01/1988 - "The diffuse staining pattern of EMA and S-100 and the difference in staining patterns of EMA and CEA in PLGA is distinct from that found in adenoid cystic carcinoma. " 12/01/2009 - "Adenoid cystic carcinoma (AdCC) and polymorphous low-grade adenocarcinoma (PLGA) have several common histological and clinicopathological features that may create diagnostic difficulties. " 06/01/2008 - "DISCUSSION: The morphologic diversity and cytological uniformity of PLGA may make the differential diagnostic difficult especially with adenoid cystic carcinoma and pleomorphic adenoma. " Order ALL the reference details at left...
10.	ParaffinIBA 04/01/1997 - "Ki-67 as a prognostic marker in adenoid cystic carcinoma assessed with the monoclonal antibody MIB1 in paraffin sections." 05/01/2003 - "METHODS: Immunohistochemistry using 'catalized signal amplification' (CSA) detection system was applied to paraffin-embedded specimens of polymorphous low-grade adenocarcinoma, adenoid cystic carcinoma and acinic cell carcinoma. " 01/01/1990 - "When 182 paraffin-embedded examples of human salivary gland tumors, including 112 benign and 70 malignant neoplasms, were examined immunohistochemically, positive immunoreactivity was observed in: 51 cases with NSE (59%) and 46 cases with Leu-7 (54%) of 86 pleomorphic adenomas; 11 cases with Leu-7 (61%) of 18 Warthin's tumors; 7 cases with Leu-7 (58%) of 12 acinic cell carcinomas; 5 cases with NSE (31%) of 16 adenoid cystic carcinomas; 5 cases with NSE (42%) and 4 cases with Leu-7 (33%) of 12 adenocarcinomas; 4 cases with NSE (25%) and 6 cases with Leu-7 (38%) of 16 undifferentiated carcinomas. " 04/01/2000 - "Enzymatic cell separation specimens were prepared from paraffin-embedded tissues of 18 sweat gland carcinomas (14 porocarcinomas, one classic eccrine adenocarcinoma, two microcystic adnexal carcinomas and one mostly ductal apocrine carcinoma) and 47 benign sweat gland tumours (three syringocystadenomas, five spiradenomas, 14 cylindromas, three syringomas, seven nodular hidradenomas, 10 cutaneous mixed tumours, four poromas and one apocrine hidrocystoma). " 11/01/1990 - "Flow cytometric analysis of nuclear DNA content was performed in 26 adenoid cystic carcinomas of the submandibular gland using archived, paraffin-embedded tissues. " Order ALL the reference details at left...

Therapies and Procedures

1.	Radiotherapy 02/01/1993 - "Our experience suggests that surgical treatment and adjunctive radiotherapy is beneficial in patients with adenoid cystic carcinoma." 10/01/1984 - "Our experience suggests that adjunctive radiotherapy is beneficial in patients with adenoid cystic carcinoma." 08/01/1996 - "PURPOSE: To examine the efficacy of fast neutron radiotherapy for the treatment of patients with locally advanced, adenoid cystic carcinoma of minor salivary glands and to identify prognostic variables associated with local control, overall survival, and cause specific survival. " 10/01/2008 - "CONCLUSIONS: Fast neutron radiotherapy is an effective treatment for locally advanced adenoid cystic carcinoma of the trachea, with acceptable treatment-related toxicity." 08/01/2000 - "Wide local excision and radical postoperative radiotherapy seems to be an effective treatment for adenoid cystic carcinoma of the salivary glands." Order ALL the reference details at left...
2.	Drug Therapy (Chemotherapy) 12/01/1987 - "After discussion of problems, conservative surgery is indicated as the most suitable treatment in these cases, considering that chemotherapy and radiation therapy alone are not highly effective in treating cylindromas and, furthermore, they are contraindicated because of the young age of the patient." 09/01/1981 - "Within four weeks--the entire dosage of Cisplatinum was 400 mg--the patient came into complete remission, clinically and histologically, suggesting that the adenoid cystic carcinoma may be more susceptible to chemotherapy than thought up to the present day. " 07/01/1997 - "All patients referred for palliative chemotherapy of metastatic, symptomatic, histologically confirmed adenoid cystic carcinoma between November 1990 and February 1994 were considered for this study. " 02/01/2010 - "[A case of adenoid cystic carcinoma of the thoracic esophagus after neoadjuvant chemotherapy]" 01/01/2007 - "Adenoid cystic carcinoma of the salivary glands is characterized by a poor response to chemotherapy. " Order ALL the reference details at left...
3.	Solid-State Lasers 05/01/2004 - "Nd:YAG laser for effective treatment of multiple cylindroma of the scalp." 02/01/1996 - "Primary adenoid cystic carcinoma of the trachea effectively treated with the endoscopic Nd-YAG laser followed by radiation." 05/01/2004 - "A 60-year-old woman with multiple cylindroma covering the whole scalp area was treated with a Nd:YAG laser in a cutting continuous mode. " 07/01/2000 - "[A case of adenoid cystic carcinoma of the trachea resected surgically after Nd-YAG laser therapy]" 01/01/1996 - "Among patients treated with Nd:YAG laser preoperatively, the indications were completely achieved in all 14 patients, except for 1 patient with adenoid cystic carcinoma who underwent treatment of the right mainstem bronchus. " Order ALL the reference details at left...
4.	Combination Drug Therapy (Combination Chemotherapy) 08/01/1993 - "Combination chemotherapy for a senile patient with adenoid cystic carcinoma of the esophagus: a case report." 03/01/1987 - "The authors conclude that CVF is a well-tolerated combination chemotherapy program with activity in adenoid cystic carcinoma of the head and neck. " 09/01/1984 - "Adenoid cystic carcinoma of the oesophagus: report of a case not responding to combination chemotherapy." 06/01/1989 - "Cisplatin combination chemotherapy in squamous cell carcinoma and adenoid cystic carcinoma of the skin." 06/01/1989 - "Multiple metastatic lesions of adenoid cystic carcinoma of the skin completely regressed after two courses of the combination chemotherapy with cisplatin and adriamycin. " Order ALL the reference details at left...
5.	Brachytherapy 03/01/2008 - "CONCLUSION: HDR-Ir brachytherapy is an effective method for the treatment of local recurrences of an adenoid cystic carcinoma, even after preradiotherapy. " 02/01/2003 - "DESIGN: A 40-year old man, 9 months' status postresection of a bronchial adenoid cystic carcinoma, was diagnosed by clinical evaluation and fine-needle aspiration biopsy and treated with palladium-103 ophthalmic plaque brachytherapy. " 11/01/1991 - "This is probably the first report of endobronchial brachytherapy being applied for recurrent adenoid cystic carcinoma of the lung with a good response. " 10/01/2008 - "PURPOSE: To examine the efficacy of fast neutron radiotherapy in the treatment of locally advanced adenoid cystic carcinoma (ACC) of the trachea and to compare outcomes with and without high-dose-rate (HDR) endobronchial brachytherapy boost. " 03/01/2010 - "The authors present a functionally monocular patient with a well-circumscribed adenoid cystic carcinoma that was treated with local excision of the tumor with reverse plaque brachytherapy "boost" to the lacrimal tumor bed followed by a lower dose of radiotherapy to the orbit. " Order ALL the reference details at left...

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