|1.||Greene, Nicholas D E: 1 article (07/2006)|
|2.||Chitty, Lyn S: 1 article (07/2006)|
|3.||Copp, Andrew J: 1 article (07/2006)|
|4.||Mills, Kevin: 1 article (07/2006)|
|5.||Burren, Katie A: 1 article (07/2006)|
|6.||Dunlevy, Louisa P E: 1 article (07/2006)|
05/01/1988 - "These results suggest that the small ringsize alicyclic alpha-amino acid analogs containing 3-methyl group such as 3-methyl-1-aminocyclopentanecarboxylic acid (3-MeACPC) may be effective for the early detection of tumors."
08/01/1978 - "The selective affinity of [carboxyl-11C]-1-aminocyclopentanecarboxylic acid (ACPC) for tumor tissue has led us to study the tumor-localizing characteristics of a series of alicyclic alpha-amino acid analogs of ACPC. "
08/01/1970 - "Phase II study of 1-aminocyclopentanecarboxylic acid (NSC-1026) in patients with cancer."
12/01/1965 - "Phase I study of 1-aminocyclopentanecarboxylic acid (NSC-1026) in cancer patients."
02/01/1983 - "Ki values for cycloleucine and (+/-)-2-aminobicyclo[2.1.1]hexane-2-carboxylic acid, presented for each tumor and liver isozyme, indicate that (+/-)-2-aminobicyclo[2.1.1]hexane-2-carboxylic acid was the more potent inhibitor. "
|2.||Sarcoma (Soft Tissue Sarcoma)
01/01/1981 - "Lower doses of cycloleucine (200 mg/kg) yielded less toxicity but were less effective against the sarcomas (6% response rate, three of 51 patients). "
03/01/1981 - "Phase II evaluation of cycloleucine in the treatment of patients with disseminated sarcomas."
01/01/1981 - "In this patient series, doxorubicin and cycloleucine at a dose of 300 mg/kg both show response rates in the treatment of advanced soft tissue sarcomas of about 15%. "
01/01/1981 - "Comparison of doxorubicin with cycloleucine in the treatment of sarcomas."
07/10/1979 - "Cycloleucine (1-aminocyclopentane-1-carboxylic acid) is a potent inhibitor of RNA methylation in B77 sarcoma virus-infected chicken embryo fibroblasts. "
07/01/1972 - "Hepatic and skeletal muscle transport of cycloleucine during starvation."
04/01/1993 - "Starvation increases Na(+)-dependent L-alanine uptake and Na(+)-independent cycloleucine uptake by small-intestinal brush-border membrane vesicles. "
07/25/1982 - "The concentration of AdoMet decreased from 0.4 mM to 0.3 mM during starvation but when cycloleucine, an inhibitor of AdoMet synthetase, was used to decrease [AdoMet] by a similar amount in histidine-fed cells there was little change in tumbling frequency. "
04/01/1979 - "There was no starvation-induced increase in the transport of leucine, phenylalanine, lysine, or cycloleucine. "
11/01/1978 - "Experimental cystinuria: the cycloleucine model. "
06/15/1978 - "Cycloleucine is a synthetic amino acid which produces, in vivo, biochemical abnoramlities comparable to those seen in human cystinuria-lysinuria. "
12/01/1975 - "Experimental cystinuria: the cycloleucine model. "
07/01/1971 - "[Modification of aminoaciduria in the rat after administration of cycloleucine: comparison with human cystinuria]."
12/01/1975 - "The injection of cycloleucine (1-aminocyclopentanecarboxylic acid (ACPC) into rats produces a hyperexcretion of dibasic amino acids and cystine, an aberration resembling cystinuria. "
|5.||Subacute Combined Degeneration
06/01/1992 - "Cycloleucine (CL), an inhibitor of methionine adenosyltransferase, has previously been used to produce an experimental model of subacute combined degeneration of the spinal cord. "
01/01/1986 - "Cells treated with 30 microM sinefungin, which inhibits myelin basic protein methyltransferase in broken cell preparations about 60%, produced ringlike structures that were devoid of multilamellar periodicity and compactness reminiscent of the vacuolated myelin observed in subacute combined degeneration and in nitrous-oxide- or cycloleucine-treated animals in which methyltransferase activity is also inhibited. "
06/01/1993 - "Cycloleucine, tellurium, and 1,3-dinitrobenzene provide models of subacute combined degeneration, primary peripheral nerve demyelination, and thiamine deficiency-like lesions, respectively. "
|3.||RNA (Ribonucleic Acid)
|9.||Glutamic Acid (Glutamate)
|10.||Tilorone (Tilorone Hydrochloride)