Cyclodextrins

A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. The enzyme is produced by certain species of Bacillus. Cyclodextrins form inclusion complexes with a wide variety of substances.

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Networked: 1345 relevant articles (117 outcomes, 203 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Motoyama, Keiichi: 32 articles (01/2022 - 10/2009)
2.	Arima, Hidetoshi: 30 articles (09/2020 - 10/2009)
3.	Higashi, Taishi: 27 articles (01/2022 - 06/2012)
4.	Quintans-Júnior, Lucindo J: 17 articles (10/2022 - 09/2013)
5.	Araújo, Adriano A S: 16 articles (07/2021 - 09/2013)
6.	Liu, Yu: 14 articles (12/2022 - 10/2003)
7.	Bilensoy, Erem: 14 articles (07/2022 - 11/2009)
8.	Menezes, Paula P: 13 articles (07/2021 - 09/2013)
9.	Onodera, Risako: 12 articles (01/2022 - 10/2009)
10.	Trotta, Francesco: 10 articles (05/2022 - 11/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "The review showed that cyclodextrin/anticancer drug complexes enhance solubility, reduce toxicity, and improve therapeutic efficacy in in vivo tumor models in the pharmacokinetic studies detailed and described below. " 12/07/2016 - "Supramolecular cyclodextrin nanocarriers for chemo- and gene therapy towards the effective treatment of drug resistant cancers." 01/01/2009 - "Cyclodextrin polymerized nanoparticles are an enabling technology for the safe and effective delivery of tubulysins for the treatment of cancer." 01/01/2020 - "We reviewed in vivo experimental studies of drug molecules complexed in cyclodextrins to evaluate whether these complexes improved bioavailability and enhanced the treatment of cancer, the second leading cause of death globally. " 01/01/2023 - "Interactions between β-cyclodextrin as a carrier for anti-cancer drug delivery: a molecular dynamics simulation study."
2.	Infections 03/01/2021 - "SS2 infection also caused dynamic changes in the localization of RPSA and CAV1 on the cell surface which could be eliminated by disruption of caveolae/rafts by addition of methyl-β-cyclodextrin (MβCD). " 07/01/2019 - "In this study, we have examined the ability of a novel sulfonated derivative of β-cyclodextrin (KS-6469) to inhibit the influenza virus A/WSN/33 (H1N1) infection in vitro and in vivo. " 08/01/2023 - "β-cyclodextrins also prevented infection in a human nasal epithelium model ex vivo and had a prophylactic effect in the nasal epithelium of hamsters in vivo. " 02/01/2021 - "The application of a cyclodextrin-trap for complexation of signal molecules may be a novel, promising method for influencing QS interfering strategies, for example, to enhance the efficiency of various biotechnologies, as well as to find alternative approaches against bacterial proliferation and infections. " 07/01/2019 - "A Novel Sulfonated Derivative of β-Cyclodextrin Effectively Inhibits Influenza A Virus Infection in vitro and in vivo."
3.	Melanoma (Melanoma, Malignant) 04/20/2020 - "Poly(cyclodextrin)-Polydrug Nanocomplexes as Synthetic Oncolytic Virus for Locoregional Melanoma Chemoimmunotherapy." 01/31/2023 - "Copper (II) Species with Improved Anti-Melanoma and Antibacterial Activity by Inclusion in β-Cyclodextrin." 07/01/2020 - "In this paper, we described the complexation of harman (HAR) with β-cyclodextrin (βCD) as a promising alternative to improve its solubility and consequently its cytotoxic effect in chemoresistant melanoma cells (A2058 cell line). " 07/01/2020 - "Complexation with β-cyclodextrin enhances apoptosis-mediated cytotoxic effect of harman in chemoresistant BRAF-mutated melanoma cells." 01/01/2017 - "Rutin and Its Cyclodextrin Inclusion Complexes: Physico-chemical Evaluation and in vitro Activity on B164A5 Murine Melanoma Cell Line."
4.	Breast Neoplasms (Breast Cancer) 01/01/2021 - "In the present work binding affinities and interactions between various anti-cancerous drugs and β- cyclodextrin using molecular docking simulations was examined for the bioavailability enhancement of cytotoxic drugs through improved solubility for the treatment of breast cancer. " 01/01/2022 - "Unsymmetrical, monocarboxyalkyl meso-arylporphyrins in the photokilling of breast cancer cells using permethyl-β-cyclodextrin as sequestrant and cell uptake modulator." 01/01/2019 - "Consistently, CFZ-alb NC showed greater anticancer efficacy in a murine 4T1 orthotopic breast cancer model than the currently used cyclodextrin-based formulation. " 10/15/2018 - "Global omics strategies to investigate the effect of cyclodextrin nanoparticles on MCF-7 breast cancer cells." 01/26/2018 - "Cellular Interaction and Tumoral Penetration Properties of Cyclodextrin Nanoparticles on 3D Breast Tumor Model."
5.	Atherosclerosis 12/01/2020 - "In this study, we explored biocompatible paramagnetic iron-oxide nanoparticles (NPs) in a complex with low pH-sensitive cyclodextrin for the diagnostic imaging and treatment of atherosclerosis. " 12/01/2020 - "Cyclodextrin related drug delivery system to promote atherosclerosis regression." 10/01/2020 - "Accordingly, cyclodextrins could be considered as potentially effective therapeutic agents for the treatment of atherosclerosis. " 04/06/2016 - "Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming." 10/01/2020 - "Cyclodextrins: Potential therapeutics against atherosclerosis."

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