|1.||de Groot, S: 2 articles (06/2007 - 12/2006)|
|2.||Renwick, A G: 2 articles (12/2003 - 01/2000)|
|3.||Dewinter, Louise: 1 article (01/2016)|
|4.||Van der Vaerent, Katrien: 1 article (01/2016)|
|5.||Corthouts, Karen: 1 article (01/2016)|
|6.||Van de Kerckhove, Kristel: 1 article (01/2016)|
|7.||Vanmeerbeeck, Kelly: 1 article (01/2016)|
|8.||Casteels, Kristina: 1 article (01/2016)|
|9.||Matthys, Christophe: 1 article (01/2016)|
|10.||Kamenickova, Alzbeta: 1 article (12/2013)|
01/01/1992 - "The weight of the evidence from metabolic studies, short-term tests, animal bioassays, and epidemiological studies indicates that cyclamate (CHS) is not carcinogenic by itself; however, there is evidence from in vitro and in vivo studies in animals that implies it may have cancer-promoting or cocarcinogenic activity. "
01/01/2000 - "Malignant tumors were diagnosed in three 24-year-old cyclamate monkeys; these were metastatic colon carcinoma (rhesus; 500 mg/kg), metastatic hepatocellular carcinoma (cynomolgus; 500 mg/kg), and a small, well differentiated adenocarcinoma of the prostate (cynomolgus; 100 mg/kg). "
02/01/1982 - "The strong correlation between tumor-promoting activity and the capacity to inhibit nerve growth factor-induced neurite outgrowth for a number of compounds prompted studies on the suspected bladder tumor promoters saccharin and cyclamate. "
02/20/1970 - "Papillary transitional cell tumors were found in the urinary bladders in 8 rats out of 80 that received 2600 milligrams per kilogram of body weight per day of a mixture of sodium cyclamate and sodium saccharin (10:1) for up to 105 weeks. "
10/01/1986 - "With the exception of studies on non-nutritive sweeteners like saccharin and cyclamate, or those on nitrate and nitrite, very few epidemiologic studies have been conducted to examine the effect of food additives on cancer risk. "
|2.||Urinary Bladder Neoplasms (Bladder Cancer)
11/15/1983 - "Neither saccharine nor cyclamate users had an increased risk of bladder cancer. "
08/01/1977 - "Although this is not a conclusive indictment of the role of cyclamates we believe that patients with bladder cancer should be questioned about intake of cyclamates either directly or in diet soft drinks."
08/01/1977 - "Three cases of human bladder cancer following high dose cyclamate ingestion."
06/01/1972 - "[Lack of a syncarcinogenic effect of cyclamate in inducing bladder neoplasms by butyl-butanol-nitrosamine in rats]."
11/08/1971 - "[Diabetes mellitus--cyclamates--bladder cancer?]."
|3.||Kidney Diseases (Kidney Disease)
06/01/1969 - "[Continued clinical studies on the question of toxicity of prolonged administrations of cyclamate in the patients with liver and kidney diseases]."
12/01/1967 - "[Clinical studies on the question of toxicity of prolonged administration of cyclamate in patients with liver and kidney diseases]."
01/01/1988 - "Calcium cyclamate is negative in both tests; therefore, there is no evidence of induced chromosome breakage and exchange."
05/01/1973 - "More acrocentric-type chromosomal breaks (21.7%) were seen in the untreated cells than the cells treated with cyclamate (3.4%) or dimethylbenzanthracene alone (4.8%). "
05/01/1973 - "Sodium cyclamate had only slightly more chromosomal breaks than the controls (11.6 compared to 10.9%). "
05/02/1969 - "Chromosome studies on human cells in vitro have shown that the artificial sweeteners, sodium and calcium cyclamate, can induce chromosome breaks in vitro in human cells, in both leukocyte and monolayer cultures."
|5.||Chromosome Aberrations (Chromosome Abnormalities)
01/01/1984 - "Phase I was primarily orientation studies of the effects of cyclamates and included running preliminary test checks, the establishment of parameters of dosage, assessing growth patterns and selecting key chromosomal aberrations. "
01/01/1988 - "Calcium cyclamate, an artificial sweetener, was studied for its effectiveness in inducing transmissible chromosomal aberrations in germ cells of male mice. "
01/01/1984 - "It was determined that calcium cyclamate impaired the synthesis of deoxribonunucleic acid (as depicted by decreased incorporation of tritiated thymidine), reduced grain counts in autoradiographs and increased chromosome aberrations in cyclamate treated PHA stimulated peripheral blood lymphocytes in vitro. "
|2.||Sweetening Agents (Sweeteners)
|3.||Food Additives (Food Additive)
|6.||Nerve Growth Factor (NGF)
|8.||Cytochrome P-450 CYP1A1 (CYP1A1)
|9.||Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)