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Cyanoketone
2 alpha-Cyano-17 beta-hydroxy-4,4',17 alpha-trimethylandrost-5-ene-3-one. An androstenolone-nitrile compound with steroidogenesis-blocking activity.
Also Known As:
Androst-5-ene-2-carbonitrile, 17-hydroxy-4,4,17-trimethyl-3-oxo-, (2alpha,17beta)-
Networked:
5
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Androstanes: 11
Androstenes: 5
Androstenols
Cyanoketone: 5
Win 19578
Related Diseases
1.
Hypertrophy
12/01/1983 - "
These studies were performed to determine how bilateral adrenal hypertrophy persists despite normal resting ACTH levels in male rats for weeks after a 3-day course of treatment with cyanoketone (CK).
"
12/01/1983 - "
Adrenal hypertrophy was induced by treatment of rats for 3 days with aminoglutethimide, cyanoketone, or metyrapone, three agents that act to inhibit enzymes required for corticosterone synthesis.
"
2.
Neoplasms (Cancer)
07/01/1976 - "
Cyanoketone produces about as many regresssions of these cancers as does ovariectomy.
"
07/01/1976 - "
However, cyanoketone with corticosterone results in a significant regression of tumors in all animals tested.
"
07/01/1976 - "
The effects of cyanoketone, a specific inhibitor of steroidogenesis at the levels of 3beta-hydroxysteroid oxidoreductase-dealta54-3-ketosteroid isomerase, the combination of cyanoketone with corticosterone, and corticosterone alone on the growth of dimethylbenzanthracene-induced hormone-dependent breast cancers in rats were compared with that produced by ovariectomy.
"
08/01/1982 - "
The inhibitory activity of aminoglutethimide, 4-hydroxyandrostenedione, 7 alpha-(4'-amino)phenylthioandrostenedione, and cyanoketone (2 alpha-cyano-4,4,17 alpha-trimethyl-17 beta-hydroxy-5-androstene-3-one) on androgen aromatization by human mammary tumors was examined.
"
3.
Atrophy
11/01/1995 - "
Treatment of chronically stressed rats with the steroid synthesis blocker cyanoketone prevented stress-induced dendritic atrophy.
"
Related Drugs and Biologics
1.
Adrenocorticotropic Hormone (ACTH)
2.
Corticosterone
3.
Aminoglutethimide (Cytadren)
4.
Steroids
5.
Metyrapone
6.
Isomerases
7.
Hormones (Hormone)
8.
Enzymes
9.
Androgens
10.
7-(4'-amino)phenylthioandrostenedione
Related Therapies and Procedures
1.
Ovariectomy (Oophorectomy)