Cutis Laxa

Subscribe to Selected New Research on Cutis Laxa

101 relevant articles (1 outcomes, 6 trials/studies) found for this Disease

Description: A group of connective tissue diseases in which skin hangs in loose pendulous folds. It is believed to be associated with decreased elastic tissue formation as well as an abnormality in elastin formation. Cutis laxa is usually a genetic disease, but acquired cases have been reported. (From Dorland, 27th ed)

Also Known As:

Dermatolyses; Dermatolysis; Dermatomegaly

Relationship Network

Disease Context: Research Results

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 420

Inborn Genetic Diseases: 548

Genetic Skin Diseases: 10

Cutis Laxa: 101

Skin and Connective Tissue Diseases

Skin Diseases: 5932

Genetic Skin Diseases: 10

Cutis Laxa: 101

Connective Tissue Diseases: 1629

Cutis Laxa: 101

Related Diseases

1.	Syndrome
2.	Wounds and Injuries (Trauma)
3.	Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos)
4.	Osteogenesis Imperfecta (Lobstein Disease)
5.	Marfan Syndrome (Marfan's Syndrome)
50 Diseases and 53 more articles analyzed in the Research Interface, order at left...

Experts

1.	Urban, Zsolt: 4 articles (01/2008 - 06/2005)
2.	Morava, Eva: 2 articles (01/2008 - 06/2005)
3.	Sasaki, Takako: 2 articles (11/2007 - 04/2003)
4.	Markova, Dessislava: 2 articles (11/2007 - 04/2003)
5.	Chu, Mon-Li: 2 articles (11/2007 - 04/2003)
6.	Essayie, Maximilian: 1 article (04/2008)
7.	Kraus, Cornelia: 1 article (04/2008)
8.	Hausser, Ingrid: 1 article (04/2008)
9.	Graul-Neumann, Luitgard M: 1 article (04/2008)
10.	Rauch, Anita: 1 article (04/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cutis Laxa:

1.	PlasticsIBA 03/01/1993 - "Congenital cutis laxa is a deforming disease that may present for plastic surgical consultation during childhood" 03/01/1993 - "Plastic surgical procedures can be aesthetically and psychologically beneficial in children with congenital cutis laxa, and can be recommended without overt fear of wound disruption, poor scarring, and medical catastrophies that can occur with other hyperelasticity syndromes." Get all the results and reference details, order at left...
2.	ElastinIBA 04/01/2003 - "In the present study, we analyzed the gene expression of elastin and fibulins 1-5 in fibroblasts from five patients with cutis laxa" 04/15/2008 - "Highly variable cutis laxa resulting from a dominant splicing mutation of the elastin gene." 11/01/2007 - "Cutis laxa (CL) is an extremely inherited or acquired connective tissue disorder characterised by a markedly reduced systemic elastin content" 07/01/2006 - "Mutations in the elastin coding gene have been shown to cause autosomal dominant cutis laxa in three families" 03/01/2006 - "Aortic aneurysmal disease and cutis laxa caused by defects in the elastin gene." Get all the results and reference details, order at left...
3.	CollagenIBA 01/01/1987 - "Collagen studies in congenital cutis laxa." 09/01/1991 - "Normal collagen synthetic activity was observed in the cutis laxa fibroblasts" 06/15/1976 - "Abnormally soluble collagen is synthesized in vitro not only by skin fibroblasts of Marfan patients but also by those of patients with Ehlers-Danlos type V and cutis laxa" 09/01/1989 - "Light and electron microscopic studies of skin from patients with inherited connective tissue disorders (e.g., Ehlers-Danlos syndrome, osteogenesis imperfecta, Marfan syndrome, cutis laxa) have led us to the following generalizations about what components change, how individual collagen or elastic fibers are altered and how individual alterations affect overall dermal organization: 1) There is a limited change in the repertoire of collagen fibrils in the skin; 2) there appears to be a greater range of abnormal structure in dermal elastic fibers than in the collagen fibrils; 3) the morphology of the fibroblastic cells may provide clues to the defect in matrix components; 4) similar structural abnormalities result from different molecular defect; 5) a molecular defect in one connective tissue molecule has consequences for the structural properties of other connective tissue components; and 6) although structural alterations in connective tissue fibers are rarely specific for a given disease, there are characteristic patterns of structural change in the matrix that may be used to confirm a diagnosis" 07/01/1982 - "Skin from patients with inherited disorders of connective tissue metabolism (EDS Types I-IX, Marfan's syndrome, osteogenesis imperfecta, spondyloepiphyseal dysplasia, and cutis laxa) has been examined by light and transmission electron microscopy for defects in the collagen and elastic fibrous connective tissue which may explain the clinical disorder and/or correlate with the biochemical defect (where known)" Get all the results and reference details, order at left...
4.	Collagen Type I (Type I Collagen)IBA 01/01/1988 - "Immunofluorescence was employed to study distribution of collagen type I, III, IV and V, and fibronectin in skin biopsy specimens from patients with Ehlers-Danlos syndrome (EDS) and cutis laxa" 01/01/1988 - "Collagen type I, III, IV and V and fibronectin in skin biopsies of patients with Ehlers-Danlos syndrome and cutis laxa]" 02/01/1976 - "Thus far, the primary heritable disorders of collagen metabolism in man include lysyl hydroxylase deficiency in Ehlers-Danlos syndrome type VI, p-collagen peptidase deficency in Ehlers-Danlos syndrome type VII, decreased synthesis of type III collagen in Ehlers-Danlos syndrome type IV, lysyl oxidase deficency in S-linked cutis laxa and Ehlers-Danlos syndrome type V, and decreased synthesis of type I collagen in osteogenesis imperfecta." Get all the results and reference details, order at left...
5.	CalciumIBA 08/01/2000 - "A 17-year-old Korean girl presented cutis laxa-like marked wrinkling on the flexural area, and a skin biopsy specimen revealed multiple foci of ossification with irregularly clumped, basophilic-stained elastic fibers in the reticular dermis and calcium deposits along the elastic fibers" 09/01/2002 - "Molecular study of the fibulin-5 (FBLN5) gene in a large consanguineous Turkish family with four patients affected by AR cutis laxa type I demonstrated the presence of a homozygous missense mutation (T998C) in the FBLN5 gene resulting in a serine-to-proline (S227P) substitution in the fourth calcium-binding epidermal growth factor-like domain of fibulin-5 protein" Get all the results and reference details, order at left...
6.	Serine (L-Serine)FDA Link 09/01/2002 - "Molecular study of the fibulin-5 (FBLN5) gene in a large consanguineous Turkish family with four patients affected by AR cutis laxa type I demonstrated the presence of a homozygous missense mutation (T998C) in the FBLN5 gene resulting in a serine-to-proline (S227P) substitution in the fourth calcium-binding epidermal growth factor-like domain of fibulin-5 protein" Get all the results and reference details, order at left...
7.	Proline (L-Proline)FDA Link 09/01/2002 - "Molecular study of the fibulin-5 (FBLN5) gene in a large consanguineous Turkish family with four patients affected by AR cutis laxa type I demonstrated the presence of a homozygous missense mutation (T998C) in the FBLN5 gene resulting in a serine-to-proline (S227P) substitution in the fourth calcium-binding epidermal growth factor-like domain of fibulin-5 protein" Get all the results and reference details, order at left...
8.	Fibronectins (Fibronectin)IBA 01/01/1988 - "Immunofluorescence was employed to study distribution of collagen type I, III, IV and V, and fibronectin in skin biopsy specimens from patients with Ehlers-Danlos syndrome (EDS) and cutis laxa" 01/01/1988 - "Collagen type I, III, IV and V and fibronectin in skin biopsies of patients with Ehlers-Danlos syndrome and cutis laxa]" 01/01/1988 - "Abnormal distribution of collagen type V in the skin biopsies was found out in EDS type VII. A high level of dermal fibronectin occurred in EDS type III. Tissue fibronectin was absent in the skin extracellular matrix in EDS type X. Defective distribution of collagen, predominantly of type III and V and fibronectin absence were registered in the skin connective tissue in cutis laxa." Get all the results and reference details, order at left...
9.	Epidermal Growth Factor (EGF)IBA 09/01/2002 - "Molecular study of the fibulin-5 (FBLN5) gene in a large consanguineous Turkish family with four patients affected by AR cutis laxa type I demonstrated the presence of a homozygous missense mutation (T998C) in the FBLN5 gene resulting in a serine-to-proline (S227P) substitution in the fourth calcium-binding epidermal growth factor-like domain of fibulin-5 protein" Get all the results and reference details, order at left...
10.	Penicillamine (Cuprimine)FDA Link 07/01/2005 - "Elastosis perforans serpiginosa secondary to D-penicillamine therapy with coexisting cutis laxa." 08/01/1994 - "Induction of elastosis perforans serpiginosa and of cutis laxa by D-penicillamine may be due to a similar mechanism." 07/21/1979 - "Congenital cutis laxa and maternal D-penicillamine." 07/07/1979 - "Reversible cutis laxa due to maternal D-penicillamine treatment." 07/01/2005 - "Although both EPS and acquired cutis laxa can be associated with D-penicillamine therapy, few cases have been reported with overlapping clinical presentations, and previously only in patients with Wilson disease" Get all the results and reference details, order at left...
61 Drugs and Important Bio-Agents and 96 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Rhytidoplasty (Facelift) 09/01/1999 - "Repeated face lifts seem to be an interesting way to manage patients with cutis laxa" 03/01/1993 - "A face-lift and direct nasolabial fold excision was performed in a 10-year old patient with congenital cutis laxa with a good result" Get all the results and reference details, order at left...
2.	Blepharoplasty 12/01/2007 - "Localized cutis laxa and blepharoplasty." Get all the results and reference details, order at left...
3.	Mammaplasty (Breast Reconstruction) 10/01/2000 - "RESULTS: Bilateral deep inferior epigastric perforator (DIEP) flap breast reconstruction after weight reduction following VBG resulted in an esthetic pleasing result with additional correction of the cutis laxa abdominis" Get all the results and reference details, order at left...
4.	Sutures (Suture) 01/01/1996 - "This entity, although several lengths of duplicated fragment or mosaicism, is characterized by high and large forehead flattened at the centre due to the abnormally large and persistent gaping anterior fontanel and sagittal (metopic sutures, consequent hypertelorism and broad nasal bridge, cutis laxa, often denounced by folded neck, joint and cardiovascular anomalies, psychomotor delay and a possible typical dermatoglyphic pattern" Get all the results and reference details, order at left...
5.	Rhinoplasty 02/01/1979 - "Some cases of palpebral cutis laxa after rhinoplasties]" Get all the results and reference details, order at left...
6 Therapies and Procedures and 7 more articles analyzed in the Research Interface, order at left...

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License details >>

Price:

$490.00 access via web interface, 1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m", 1 year subscription

Proceed to Checkout >>