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Cuprizone

Copper chelator that inhibits monoamine oxidase and causes liver and brain damage.
Also Known As:
Oxaldihydrazone, Biscyclohexanone; Biscyclohexanone Oxaldihydrazone; Ethanedioic acid, bis(cyclohexylidenehydrazide)
Networked: 342 relevant articles (13 outcomes, 101 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Stangel, Martin: 24 articles (12/2015 - 12/2007)
2. Skripuletz, Thomas: 18 articles (12/2015 - 04/2008)
3. Gudi, Viktoria: 17 articles (12/2015 - 02/2009)
4. Kipp, Markus: 15 articles (10/2015 - 05/2009)
5. Beyer, Cordian: 14 articles (10/2015 - 05/2009)
6. Clarner, Tim: 12 articles (10/2015 - 05/2009)
7. Armstrong, Regina C: 12 articles (08/2013 - 10/2002)
8. Kilpatrick, Trevor J: 10 articles (06/2015 - 03/2008)
9. Matsushima, Glenn K: 10 articles (03/2013 - 07/2002)
10. Xu, Haiyun: 9 articles (11/2015 - 05/2009)

Related Diseases

1. Demyelinating Diseases (Demyelinating Disease)
2. Multiple Sclerosis
3. Inflammation
4. Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
01/01/2015 - "Data from animal model studies, particularly studies of experimental autoimmune encephalomyelitis (EAE) and the cuprizone model, imply an important role of the UPR activation in oligodendrocytes in the development of MS. In this review we will cover current literature on the UPR and the evidence for its role in the development of MS. "
12/01/2009 - "While experimental allergic encephalomyelitis is one of the most frequently used models to investigate MS pathology and therapeutic interventions, the cuprizone model reflects a toxic experimental model. "
10/01/2015 - "The current study examined whether overexpression of Klotho (KL) in transgenic mice can enhance remyelination following cuprizone-induced demyelination and improves the clinical outcome in experimental autoimmune encephalomyelitis (EAE). "
05/01/2006 - "Demyelination is a hallmark of MS and a prominent pathological feature of several other inflammatory diseases of the central nervous system, including experimental autoimmune encephalomyelitis, an animal model of MS. Accordingly, in this study we followed the effect of IFNgamma in the demyelination and remyelination process by using an experimental autoimmune encephalomyelitis model of demyelination/remyelination after exposure of mice to the neurotoxic agent cuprizone. "
12/01/2015 - "Residual CXCR2 expression on CNS cells in Cxcr2 (+/-) →Cxcr2 (-/-) chimeric animals slowed remyelination after both experimental autoimmune encephalomyelitis and cuprizone-induced demyelination. "
5. Schizophrenia (Dementia Praecox)

Related Drugs and Biologics

1. Omega-3 Fatty Acids (Omega 3 Fatty Acids)
2. Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
3. Hormones
4. GTP-Binding Proteins (G-Protein)
5. Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)
6. AL 8810
7. prostaglandin F2alpha receptor
8. Copper
9. sildenafil (Viagra)
10. Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)

Related Therapies and Procedures

1. Intraventricular Infusions
2. Mesenchymal Stem Cell Transplantation
3. Therapeutics
4. Spinal Injections
5. Injections