|1.||Andley, Usha P: 25 articles (01/2016 - 03/2002)|
|2.||Carver, John A: 13 articles (01/2016 - 09/2002)|
|3.||Santhoshkumar, Puttur: 13 articles (03/2014 - 12/2004)|
|4.||David, Larry L: 12 articles (01/2016 - 01/2002)|
|5.||Yao, Ke: 12 articles (05/2014 - 07/2003)|
|6.||Lampi, Kirsten J: 11 articles (01/2016 - 01/2002)|
|7.||King, Jonathan: 11 articles (02/2014 - 03/2003)|
|8.||Nagaraj, Ram H: 10 articles (01/2016 - 08/2004)|
|9.||Fujii, Noriko: 10 articles (01/2016 - 11/2012)|
|10.||Pande, Jayanti: 10 articles (08/2015 - 05/2003)|
01/01/2010 - "Collectively, these data suggest a critical role for TXNL6 in MsrA repair of essential lens proteins under oxidative stress conditions and that TXNL6 is important for MsrA defense protection against cataract. "
01/01/2016 - "The objective of this study was to determine whether the cataract-related G18V variant of human γS-crystallin has increased exposure of hydrophobic residues that could explain its aggregation propensity and/or recognition by αB-crystallin. "
10/30/2015 - "Our study on modifications of crystallins induced by ionizing irradiation may provide useful information relevant to human senile cataract formation. "
08/28/2015 - "In this study, we showed that the G129C mutation in γC-crystallin, which is associated with autosomal dominant congenital nuclear cataract, perturbed the unfolding process by promoting the accumulation of two distinct aggregation-prone intermediates under mild denaturing conditions. "
01/01/2014 - "To study the comparative structural and functional changes between wild-type (wt) and N-terminal congenital cataract causing αA-crystallin mutants (R12C, R21L, R49C, and R54C) upon exposure to different dosages of gamma rays. "
|2.||Astrocytoma (Pilocytic Astrocytoma)
03/01/2014 - "C-terminally truncated form of αB-crystallin is associated with IDH1 R132H mutation in anaplastic astrocytoma."
08/01/2009 - "To investigate the functional significance of alphaB-crystallin induction in astrocytes, we generated a stable C6 astroglioma cell line overexpressing alphaB-crystallin. "
03/19/1996 - "We have further shown that this modification is not restricted to lens alphaB-crystallin but occurs on alphaB isolated from rat heart tissue and human astroglioma cells. "
08/01/2009 - "Furthermore, the repression of alphaB-crystallin expression by alphaB-crystallin siRNA transfection suppressed this protective effect, indicating that alphaB-crystallin is responsible for the protection against H2O2-induced apoptosis in C6 astroglioma cells. "
03/19/1996 - "Metabolic pulse-chase labeling studies of U373-MG astroglioma cells indicated that turnover of the carbohydrate on alphaB-crystallin is not static but proceeds many-fold more rapidly than turnover of the protein backbone itself, consistent with a regulatory role for O-GlcNAc on this small heat shock protein."
12/01/2012 - "This study aims to evaluate αB-crystallin expression in infiltrating ductal breast carcinomas (IDCAs), as well as, its prognostic significance. "
03/01/2011 - "A recent study revealed that αB-crystallin is overexpressed in a metastatic variant of the GI101A human breast carcinoma cell line. "
09/01/2009 - "This study used immunohistochemistry to examine the expression of alphaA-crystallin and alphaB-crystallin in human sebaceous carcinoma tissues. "
06/15/2004 - "The data obtained in the current study revealed a strong association between high expression levels of alphaB-crystallin in primary breast carcinoma specimens and lymph node involvement. "
11/05/2015 - "To examine the functional consequences of αB-crystallin induction in anoikis, we stably silenced αB-crystallin in two different metastatic carcinoma cell lines. "
01/01/2016 - "Interestingly, similar to inflammation in itself, crystallins can have a beneficial or detrimental impact on the CNS based on the context and duration of the condition. "
11/01/2014 - "Lens material including γ-crystallin is extruded into the anterior and posterior chamber due to local loss of structural integrity of the lens capsule as a secondary damage to the anterior segment development leading to congenital ocular inflammation. "
09/01/2014 - "Crystallins of the α family are thought to play a crucial role in retinal neuron survival and inflammation. "
10/01/2013 - "In contrast contact with wild type crystallin did not lead to significant inflammation. "
08/01/2012 - "Our goal was to clarify not only the role of I/R injury-mediated crystallins, but also to evaluate the correlation of these compounds to anti-inflammation in the vitreous body. "
07/01/2011 - "Comment on "Chaperone activity of α B-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis"."
04/01/2011 - "Chaperone activity of α B-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis."
07/01/2010 - "Alphab-crystallin is a target for adaptive immune responses and a trigger of innate responses in preactive multiple sclerosis lesions."
07/26/2007 - "alphaB-crystallin (CRYAB) is the most abundant gene transcript present in early active multiple sclerosis lesions, whereas such transcripts are absent in normal brain tissue. "
09/15/2000 - "The myelin-associated stress protein alphaB-crystallin triggers strong proliferative responses and IFN-gamma production by human T cells and it is considered a candidate autoantigen in multiple sclerosis. "
|3.||Caspase 3 (Caspase-3)
|4.||Small Interfering RNA (siRNA)
|5.||Heat-Shock Proteins (Heat-Shock Protein)
|7.||Sodium Selenite (Selenite)
|9.||Glutathione (Reduced Glutathione)
|10.||Hydrogen Peroxide (Hydroperoxide)
|3.||Drug Therapy (Chemotherapy)