Cryptosporidiosis

09/01/2021 - "Treatment with NTZ loaded CS NPs in murine cryptosporidiosis gave the best results as it caused marked reduction in fecal oocysts counts and improvement of histopathological changes in immunocompetent and immunosuppressed groups."
02/01/2004 - "Nitazoxanide is the first agent proven to be effective in cryptosporidiosis. "
01/01/2016 - "Pulmonary cryptosporidiosis in an immunocompetent host treated successfully with nitazoxanide."
12/02/2009 - "We hypothesised that a prolonged course of treatment with high dose nitazoxanide would be effective in treating cryptosporidiosis in HIV positive Zambian children. "
01/01/2014 - "Prompt resolution of diarrhoea without adverse outcomes suggests nitazoxanide may be an effective treatment for Cryptosporidium infection in this setting. "

02/01/2002 - "At the recommended levels, paromomycin reduced the oocyst output of birds by 67-82%, showing the highest efficacy of all drugs tested against avian cryptosporidiosis thus far. "
06/27/2000 - "The objective of this study was to evaluate the therapeutic efficacy of paromomycin against cryptosporidiosis in naturally infected lambs under field conditions. "
02/01/1993 - "Recent reports suggest that paromomycin may be useful in the treatment of intestinal cryptosporidiosis. "
11/16/2002 - "A prospective, controlled-blind field trial was conducted to evaluate the efficacy and safety of paromomycin sulphate, given for 10 days from birth, in preventing natural cryptosporidiosis in calves. "
01/09/2021 - "Its inhibitory activity supersedes that of paromomycin, which is extensively used in treating cryptosporidiosis. "

07/01/2005 - "The objective of this study was to evaluate the therapeutic efficacy of azithromycin treatment of cryptosporidiosis in naturally infected calves under field conditions. "
07/01/2002 - "To study the efficacy of short-term azithromycin in the management of cryptosporidiosis. "
07/01/2005 - "Efficacy of azithromycin dihydrate in treatment of cryptosporidiosis in naturally infected dairy calves."
07/01/2005 - "From the economic point view, authors suggest that the most effective dose of azithromycin for the treatment of cryptosporidiosis in calves should be at 1,500 mg/d for 7 days."
07/01/2002 - "Azithromycin as treatment for cryptosporidiosis in human immunodeficiency virus disease."

09/01/2010 - "Halofuginone lactate was shown to be effective in reducing clinical signs of cryptosporidiosis and environmental contamination. "
12/01/2007 - "Halofuginone treatment was effective in preventing and in reducing the death rate of cryptosporidiosis in these flocks."
12/01/2007 - "Halofuginone was effective in the treatment of diarrhoea caused by cryptosporidiosis (P < 0.01). "
12/01/2007 - "The first trial was designed to assess the efficacy of halofuginone in treating lamb diarrhoea caused by cryptosporidiosis, and in preventing the disease, using two schemes; halofuginone given for seven and for three consecutive days respectively. "
01/01/2021 - "A prior systematic review on the efficacy of halofuginone (HFG) treatment to prevent or treat cryptosporidiosis in bovine calves was inconclusive. "

05/01/1994 - "Control of cryptosporidiosis is currently hampered by the absence of drugs or vaccines proven consistently effective against Cryptosporidium parvum. "
01/01/2020 - "The limited efficacy of the only available drug and lack of vaccines make it challenging to treat and prevent cryptosporidiosis. "
12/24/2017 - "Our aim is to increase awareness about the immune responses that underlie protection against cryptosporidiosis and to encourage promotion of these immune responses as a key strategy for vaccine development. "
01/01/2022 - "Studies on the pathogenesis and immune responses of Cryptosporidium infection and development of drugs and vaccines use mostly immunocompromised mouse models. "
03/04/2020 - "Further studies are needed to fully understand the specific role and functional mechanism of Cpgp40/15 (or gp40/15 complex) in the invasion of the host or in the PVM and to determine the feasibility of gp40/15 as a vaccine candidate for cryptosporidiosis in vivo."

05/14/1999 - "Hyperimmune bovine colostrum specific for recombinant Cryptosporidium parvum antigen confers partial protection against cryptosporidiosis in immunosuppressed adult mice."
01/01/2019 - "Keeping these facts in mind the present study was aimed to estimate prevalence of cryptosporidiosis in immunocompetent children, and do a comparative evaluation of its detection by microscopy with antigen detection methods. "
02/01/2015 - "The aim of the present study was to evaluate the antigen-detection capacity in the stool specimens using ELISA and oocyst detection by AP staining methods, for the diagnosis of human cryptosporidiosis. "
04/01/2011 - "This is the first report of the characterization of immune responses to cryptosporidiosis in Indian children and the first study to investigate human immune responses to the polymorphic gp40 antigen. "
12/01/2010 - "The aim of this study was to estimate the prevalence of Cryptosporidium infection by antigen detection in faeces among immunocompromised patients referred to educational hospitals of Ahvaz City, South-West of Iran, 2009-2010. "

01/01/2022 - "Initially identified by a large-scale phenotypic screening campaign, the antimycobacterial therapeutic clofazimine demonstrated great promise in both in vitro and in vivo preclinical models of Cryptosporidium infection. "
01/01/2022 - "It is unlikely that clofazimine will provide a remedy for the large number of cryptosporidiosis patients currently without a viable treatment option unless alternative, safe clofazimine formulations with improved oral absorption are developed. "
01/01/2023 - "The CRYPTOFAZ trial, previously published, was conducted in Malawi to evaluate the efficacy of clofazimine in response to an unmet need for drugs to treat cryptosporidiosis in HIV populations. "
08/23/2018 - "Evaluating the safety, tolerability, pharmacokinetics and efficacy of clofazimine in cryptosporidiosis (CRYPTOFAZ): study protocol for a randomized controlled trial."
01/01/2022 - "After establishing exposure-response relationships for clofazimine treatment of Cryptosporidium infection in our preclinical model studies, it was unmistakable that the clofazimine levels observed in the phase 2a study participants were well below concentrations associated with anti-Cryptosporidium efficacy. "

12/22/2000 - "Macrolides have been reported to be effective for the prevention of cryptosporidiosis in persons with HIV infection. "
11/01/2000 - "We summarize our experience on emerging parasitic diseases (primary amoebic meningoencephalitis, respiratory cryptosporidiosis, and diplogonoporiasis), and selected problems of bacterial resistance (MDR tuberculosis caused by Mycobacterium bovis and macrolide-resistance mechanisms of Streptococcus pneumoniae and S. "
12/01/1998 - "The efficacy of macrolides is still uncertain for the treatment of cryptosporidiosis; however, promising results were obtained with nitazoxanide. "
03/01/1992 - "A new macrolide, azithromycin, has been reported to be effective for cryptosporidiosis in experimental animals; currently, no effective therapy is available for human infections. "
06/01/1991 - "Roxithromycin, a macrolide antibiotic, was also administered to this patient with cryptosporidiosis but efficacy was not demonstrated."

05/17/2000 - "The results of our study suggest that decoquinate should have little efficacy for treatment of neonatal bovine cryptosporidiosis if administered once per day and that any clinical improvement observed in treated calves may be due to factors unrelated to decoquinate's effect on C. "
04/01/1997 - "Decoquinate reduced the severity of cryptosporidiosis in group B kids. "
09/15/2003 - "Daily treatment with decoquinate at the dosage used in this study did not affect oocyst shedding or clinical signs associated with cryptosporidiosis. "
04/01/1997 - "The purpose of this trial was to evaluate the effects of decoquinate at 2.5 mg/kg/day for 21 days to prevent an experimental cryptosporidiosis in kids. "
08/27/2005 - "Effect of different decoquinate treatments on cryptosporidiosis in naturally infected cashmere goat kids."

11/01/1995 - "The higher prevalence of specific anti-Cryptosporidium antibodies and the absence of Cryptosporidium oocysts in faecal samples from some IFA-positive animals suggests that detection of these antibodies in sera from cats could be helpful for the diagnosis of feline cryptosporidiosis."
12/01/2004 - "parvum is being attempted in ruminants for the purpose of generating hyperimmune colostrum containing antibodies that may be effective in passive immunotherapy against cryptosporidiosis in the young. "
11/09/2023 - "Anti-Cryptosporidium oocysts polyclonal antibodies for cryptosporidiosis diagnosis and protection."
08/09/2023 - "The seroprevalence of both anti- Cp23 and Cp17 antibodies was high at ≤ one year of age and reflected the exposure of these children in this community to cryptosporidiosis. "
03/01/2020 - "parvum antibodies and manifestation of clinical cryptosporidiosis (r=-0.425). "

08/01/1994 - "In the absence of an effective treatment for cryptosporidiosis, the cornerstone of management is mainly supportive therapy."
01/01/2023 - "Finally, we discuss how both our results and the current scientific literature suggest that GM modulations, either by probiotics or FMT, can become novel treatment options for chronic Cryptosporidium infection and its consequent complications, especially in those patients who do not respond to the currently available anti-parasitic therapies."
03/15/2018 - "The aim of this study was to evaluate the efficacy of two cryptosporidiosis therapies in captive green iguanas. "
06/01/2017 - "Cryptosporidium infections were not associated to diarrhoea in HIV-positive patients, probably because improved immune function in the affected individuals due to antiretroviral therapy. "
01/01/2002 - "With further clarification of the mechanisms underlying enterocyte malfunction in Cryptosporidium infection, it should be possible to design rational nutritional and pharmacologic therapies to enhance nutrient and water absorption, promote the clearance of infected enterocytes, and restore normal villus architecture and mucosal barrier function."

03/01/2002 - "Because of reported efficacy of antibody-based immunotherapy, we studied the effect of inexpensive, commercially available oral bovine serum concentrate (BSC) in experimental cryptosporidiosis. "
01/01/1998 - "Passive antibody immunotherapy (PAI) for cryptosporidiosis is a treatment strategy that has been actively pursued in laboratory studies and early-stage clinical studies for the last decade. "
09/01/2017 - "Until now, there are no completely effective parasite-specific pharmaceuticals or immunotherapies for treatment against the zoonotic cryptosporidiosis. "
02/01/2012 - "No consistently effective parasite-specific pharmaceuticals or immunotherapies for control of cryptosporidiosis are presently available. "
11/01/2011 - "Cryptosporidiosis: host immune responses and the prospects for effective immunotherapies."

03/01/2000 - "Since a fair number of cryptosporidiosis cases are still being reported in the New Orleans area after the introduction of highly active antiretroviral therapy, further studies are needed to provide insight into the existence of potential environmental sources of Cryptosporidium."
08/01/2014 - "Resolution of Cryptosporidiosis can be maintained with effective Highly Active Antiretroviral Therapy (HAART)."
01/01/2007 - "Cryptosporidiosis causes significant morbidity and mortality in human immunodeficiency virus (HIV)-infected patients who do not receive highly active antiretroviral therapy. "
12/01/2004 - "HIV-infected patients on highly active antiretroviral therapy have a dramatically lower incidence of cryptosporidiosis, attributable to the effects of intestinal immune reconstitution as well as the effect on the CD4 cell count. "
06/01/2004 - "[Highly Active AntiRetroviral Therapy and cryptosporidiosis]."

12/01/2021 - "Current pharmacotherapy of cryptosporidiosis: an update of the state-of-the-art."
09/01/2011 - "No fully effective approved drug therapy exists for Cryptosporidium infections of immunocompetent and immunocompromised patients. "
09/01/2008 - "No effective approved drug therapy exists for Cryptosporidium infection of immunocompromised patients. "
07/01/2004 - "The slow development of anti-cryptosporidiosis chemotherapy is primarily due to the poor understanding on the basic metabolic pathways in this parasite. "
06/01/2004 - "In prospect, PIs could be valuable for the chemotherapy of cryptosporidiosis."

06/01/1993 - "The nodule became smaller in one patient when cholestasis improved after treatment for cryptosporidiosis. "
11/01/1989 - "Resolution of intestinal cryptosporidiosis after treatment of AIDS with AZT."
03/30/2020 - "Cryptosporidiosis after treatment with fingolimod: a case report and pharmacovigilance review."
01/01/1996 - "We report two cases of cryptosporidiosis which were unusual because (i) extracellular invasive forms of the parasite were found in the bronchoalveolar lavage and (ii) the outcome was favorable in one patient after treatment with azithromycin."
04/01/1997 - "Resolution of AIDS associated cryptosporidiosis after treatment with indinavir."