Croton Oil

Viscous, nauseating oil obtained from the shrub Croton tiglium (Euphorbaceae). It is a vesicant and skin irritant used as pharmacologic standard for skin inflammation and allergy and causes skin cancer. It was formerly used as an emetic and cathartic with frequent mortality.

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Networked: 791 relevant articles (31 outcomes, 72 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sosa, Silvio: 15 articles (07/2017 - 06/2004)
2.	Tubaro, Aurelia: 15 articles (11/2014 - 05/2004)
3.	Oliveira, Sara Marchesan: 12 articles (03/2021 - 01/2016)
4.	Camponogara, Camila: 11 articles (03/2021 - 02/2016)
5.	Piana, Mariana: 9 articles (03/2020 - 02/2016)
6.	Scio, Elita: 8 articles (01/2021 - 06/2013)
7.	Cabrini, Daniela Almeida: 8 articles (04/2020 - 07/2008)
8.	Kim, Hyun Pyo: 7 articles (09/2020 - 04/2002)
9.	Bersani-Amado, Ciomar A: 6 articles (11/2021 - 07/2015)
10.	Hajhashemi, Valiollah: 6 articles (09/2021 - 01/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2002 - "Topical application of the nutraceuticals daily for 5 days before DMBA and 1 h before croton oil (Protocol 1) and immediately after croton oil (Protocol 3) did not have an additional protective effect against skin tumors compared with Protocol 2. Kruskal-Wallis analysis of variance by ranks showed that Protocol 2 is the most effective, with the treatment groups belonging to different populations at the 0.05 level of significance compared with alpha = 0.20 for Protocols 1 and 3. Turmeric is the most potent nutraceutical, because the average number of tumors formed after application of tumeric is statistically different from the positive control at alpha = 0.01." 05/01/2010 - "asoka), 30 min prior to the application of croton oil thrice weekly for 20 weeks, caused a significant reduction in the number of tumors per mouse and the percentage of tumor-bearing mice. " 01/01/2013 - "This study was conducted for 12 weeks on two-stage 7,12-dimethylbenz(α)-anthracene (DMBA)-induced tumor initiation followed by croton-oil-induced tumor promotion in mice. " 08/01/1988 - "Thus under the circumstances of this study croton oil did promote UV initiated tumor formation but BPO did not. " 10/01/2023 - "The DMBA/Croton oil-induced mice exhibited 100% tumor incidence. "
2.	Inflammation (Inflammations) 01/01/1983 - "Relative protective effects of 20 homologs of 4-(2-bromo-4,5-dimethoxyphenyl)-octahydro-2H-quinolizin-2-one (JB-1-0) against croton oil induced inflammation in mice." 01/21/2023 - "In vivo studies were performed, and inflammation induced by croton oil was assessed for response to microemulsions and LCs. " 03/01/2021 - "Male Swiss mice were submitted to skin inflammation protocols by acute and repeated applications of croton oil. " 01/01/2021 - "An in vivo analysis was carried out on the most suitable formulation to ascertain its efficacy on inflamed tissues using croton oil-induced rectal inflammation in a rat model. " 06/01/2020 - "OA was also capable to reduce croton oil-induced skin inflammation. "
3.	Edema (Dropsy) 01/01/2016 - "To verify the best efficacy of principal constituents in vivo, the uniform design was used in the croton oil-induced mouse ear edema model. " 10/01/1997 - "TZZPG relieved the croton oil topical edema of ear and reduced the capillary permeability of abdominal cavity in mice. " 05/01/2017 - "In this study, local anti-inflammatory activity of these derivatives was evaluated by use of the croton oil-induced ear edema test. " 02/01/2017 - "buxifolia on croton oil or UVB radiation-induced ear edema in mice, and perform gel stability study. " 09/15/2015 - "Ear edema induced by croton oil (2.5%) in mice was used throughout the study. "
4.	Carcinogenesis 01/01/2016 - "The chemopreventive efficacy of BA was evaluated against the DMBA/Croton oil-induced skin carcinogenesis in mice.BA was orally administered at the doses of 1, 2 or 4 mg/kg/day or applied topically every day for 12 weeks following DMBA application. " 01/01/2004 - "In the present study the effects of an aqueous infusion of saffron on two stage skin papillogenesis / carcinogenesis in mice initiated by 7-12 dimethyl benz[a] anthracin (DMBA) and promoted with croton oil were investigated. " 05/01/1968 - "Experimental ultraviolet light carcinogenesis: a study of croton oil promoting effects." 07/01/2018 - "Antiangiogenic activity of the formulations was determined in chicken embryo chorioallantoic membrane (CAM) and its chemopreventive potential was evaluate during multistage DMBA and croton oil model of skin carcinogenesis in mice. " 01/01/2014 - "malabathricum leaves (MEMM) using the standard 7,12-dimethylbenz(α)anthracene (DMBA)/croton oil-induced mouse skin carcinogenesis model. "
5.	Papilloma (Papillomatosis) 01/01/2014 - "DMBA and croton oil induced papilloma development in mice was found to be delayed and prevented significantly by TEO application. " 01/01/2011 - "rimosus showed antitumor activity against DMBA initiated, croton oil promoted skin papilloma formation which can be partially ascribed to the antiperoxidative and anti-inflammatory effects of the extract." 01/01/2011 - "Similarly, topical application of extract (1 and 5 mg) effectively ameliorated the croton oil promoted skin papilloma formation. " 01/01/2011 - "It could successfully combat DMBA + croton oil-induced skin papilloma in mice as evidenced by histological, cytogenetical, immunofluorescence, ELISA and immunoblot findings. " 07/01/2009 - "Topical single application of DMBA at the dose of 4 mg/kg b.wt. followed by 1 % croton oil for 16 weeks produced a 100% incidence of skin papillomas which started appearing from the 6th week onwards. "

Related Drugs and Biologics

1.	Carrageenan
2.	anthracene
3.	Acetic Acid (Vinegar)
4.	Formaldehyde (Formol)
5.	benz(a)anthracene (benzanthracene)
6.	Acetone
7.	Phenol (Carbolic Acid)
8.	Capsaicin (Zostrix)
9.	Antioxidants
10.	Enzymes

Related Therapies and Procedures

1.	Oral Administration
2.	Subcutaneous Injections
3.	Intradermal Injections
4.	Topical Administration
5.	Traditional Medicine (Folk Remedies)