Creatine

01/01/2003 - "Creatine has been shown to be effective in several animal models of neurodegenerative diseases and currently is being evaluated in early stage trials in PD. "
05/01/2011 - "Creatine, therefore, shows great promise in the treatment of a variety of neurodegenerative diseases."
05/27/2021 - "A review of the literature was conducted to assess the current state of knowledge regarding the effects of creatine supplementation on rehabilitation from immobilization and injury, neurodegenerative diseases, cardiopulmonary disease, and other muscular disorders. "
06/01/2020 - "We report two patients with creatine deficiency among a cohort of 550 registered cases out of which 200 patients had a genetically confirmed neurodegenerative disorder diagnosis. "
05/01/2016 - "Creatine has been reported to exert beneficial effects in several neurodegenerative diseases in which glutamatergic excitotoxicity and oxidative stress play an etiological role. "

01/01/2016 - "These data strongly suggest that creatine supplementation may gain importance as a safe and effective supplement in therapeutic intervention with the anti-cancer agent MG."
11/01/2020 - "This study aimed to analyze the effect of creatine (Cr) supplementation on tumor microenvironment, evaluating the parameters of tumor aggressiveness. "
03/01/2020 - "The aim of this study was to investigate the effects of creatine supplementation on muscle wasting in Walker-256 tumor-bearing rats. "
01/01/2016 - "Exploratory studies of the potential anti-cancer effects of creatine."
01/01/2023 - "Consequently, CrT blockade failed to suppress tumor growth in the creatine-supplemented mice. "

05/01/2005 - "Although the results of this study demonstrated reduced fatigue rates in patients during high-intensity sprint intervals, further research is necessary in examining the efficacy of low-dose, short-term creatine supplementation."
06/01/1998 - "The results indicated that creatine supplementation in comparison with placebo treatment during rapid body mass reduction may help to maintain muscle PT and W(PT)1 at high angular velocities, not influencing Wmax and the rate of fatigue development during Wmax, but affecting adversely Ws max. "
06/01/1997 - "Improved fatigue resistance not associated with maximum oxygen consumption in creatine-depleted rats."
11/01/2023 - "Taking creatine for 6 months appears to improve tissue bioenergetics and attenuate clinical features of post-COVID-19 fatigue syndrome; additional studies are warranted to confirm our findings in various post-COVID-19 cohorts."
11/01/2023 - "In this parallel-group, randomized placebo-controlled double-blind trial, we analyzed the effects of 6-month creatine supplementation (4 g of creatine monohydrate per day) on various patient- and clinician-reported outcomes, and tissue creatine levels in 12 patients with post-COVID-19 fatigue syndrome. "

01/01/2013 - "However, using magnitude-based inference, supplementation with creatine post workout is possibly more beneficial in comparison to pre workout supplementation with regards to FFM, FM and 1-RM BP. The mean change in the PRE-SUPP and POST-SUPP groups for body weight (BW kg), FFM (kg), FM (kg) and 1-RM bench press (kg) were as follows, respectively: Mean ± SD; BW: 0.4 ± 2.2 vs. 0.8 ± 0.9; FFM: 0.9 ± 1.8 vs. 2.0 ± 1.2; FM: -0.1 ± 2.0 vs. -1.2 ± 1.6; Bench Press 1-RM: 6.6 ± 8.2 vs. 7.6 ± 6.1. Qualitative inference represents the likelihood that the true value will have the observed magnitude. "
06/01/2003 - "Significantly improved motor performance was present in both the 6- and 8-week treatment paradigms, while reduced body weight loss was only observed in creatine-supplemented R6/2 mice started at 6 weeks. "
06/15/2000 - "Body weight and motor performance on the rotarod test were significantly improved in creatine-supplemented R6/2 mice, whereas the onset of diabetes was markedly delayed. "
02/01/2014 - "Creatine supplementation significantly increased body weights of the athletes of endurance trial. "
06/01/2012 - "The purpose of this study was to examine the effects of 7 days of supplementation with 20 g·d⁻¹ of creatine monohydrate (CM) on mean power (MP) and peak power (PP) from the Wingate anaerobic test (WAnT), body weight (BW), 1-repetition maximum (1RM) bilateral leg extension (LE) strength, and 1RM bench press (BP) strength. "

05/01/2008 - "Protective effects of some creatine derivatives in brain tissue anoxia."
04/01/2008 - "Maternal creatine improved postnatal growth after birth hypoxia. "
02/14/2003 - "Addition of creatine, a compound that is known to afford protection against severe neuronal damage from longer periods of anoxia, prevented PS potentiation at a concentration of 10 mM, but not at a concentration of 1 mM. In addition, while 1 mM creatine by itself did not show any effect on PS amplitude of control slices, 10 mM creatine decreased PS amplitude also in such control slices, that had not been exposed to anoxia. "
01/01/2023 - "This study investigated the effects of acute hypoxia with or without fetal creatine supplementation on neuropathology in multiple brain regions. "
01/01/2021 - "Agat -/- mice died within 2 days of hypoxia, whereas Agat -/- mice supplemented with creatine and WT mice survived until the end of the study. "