|1.||Sugimoto, Miki: 4 articles (04/2013 - 02/2008)|
|2.||Ikeda, Shuntaro: 3 articles (04/2013 - 05/2011)|
|3.||Kume, Shinichi: 3 articles (04/2013 - 05/2011)|
|4.||Pagnussat, Aline S: 2 articles (03/2014 - 09/2012)|
|5.||Moura, Nathalia: 2 articles (03/2014 - 09/2012)|
|6.||Fox, Simon W: 2 articles (11/2012 - 02/2011)|
|7.||Karieb, Sahar: 2 articles (11/2012 - 02/2011)|
|8.||Ueda, Michihisa: 2 articles (06/2012 - 05/2011)|
|9.||Horiguchi, Yoshihiro: 2 articles (06/2012 - 05/2011)|
|10.||Kirihata, Yuka: 2 articles (05/2011 - 02/2008)|
|1.||Breast Neoplasms (Breast Cancer)
05/01/2008 - "Intakes of lignan, isoflavonoid, or coumestrol were not associated with breast cancer risk overall or before or after 50 y of age. "
11/01/2013 - "Coumestrol at 50μM resulted in 50% and 30% growth inhibition of human breast cancer MCF-7 and colorectal cancer HCT116 cells, respectively. "
09/27/2013 - "Based on this new methodology other coumestrol analogues were prepared, and their effects on the proliferation of the estrogen receptor (ER)-dependent MCF-7 and of the ER-independent MDA-MB-231 breast cancer cells were tested. "
04/01/2009 - "MCF7 cells, a frequent in vitro model for molecular processes associated with breast cancer, were exposed to a sub-saturating concentration of coumestrol either alone or in combination with analogs that exhibit 1000-fold lower estrogen receptor activity. "
04/01/2006 - "We examined the effect of two prevalent xenoestrogens (bisphenol A and coumestrol) on ER activation and ER-dependent mitogenesis in breast cancer cells. "
|2.||Brain Ischemia (Cerebral Ischemia)
09/20/2012 - "Coumestrol has neuroprotective effects before and after global cerebral ischemia in female rats."
03/01/2014 - "Coumestrol treatment was effective in preventing neuronal loss in all times of administration as well as able to rescue the Na+, K+ -ATPase activity, suggesting its potential benefits for either prevention or therapeutics use against cerebral ischemia in males."
01/15/2005 - "These results suggest that a single neonatal injection of 3 mg coumestrol was effective in suppressing the functions of ovulation-inducing mechanisms and the induction of lordosis, but 1mg coumestrol was effective in only the estrous cycle of female rats."
01/15/2005 - "Suppressive effect of neonatal treatment with a phytoestrogen, coumestrol, on lordosis and estrous cycle in female rats."
01/15/2005 - "Female rats were injected subcutaneously with 1 or 3mg coumestrol (CM1, CM3), 1mg genistein (GS1), 1mg estradiol (E2), or oil at day 5 after birth (birth day=day 1) and an estrous cycle check and lordosis behavior test were performed. "
07/01/2005 - "During the course of studies to characterize both activities in normal and inflamed lung and lung tumors we noted that 3alpha-HSD activity with 5alpha-DHT of microsomes from normal, adult lung was particularly susceptible to inhibition by coumestrol. "
01/01/2013 - "Finally, coumestrol exerted strong inhibition effects on the growth of three cancer cell lines. "
01/01/2013 - "In addition, coumestrol inhibited cancer cell growth partially through down-regulation of CK2-specific Akt phosphorylation. "
05/01/2008 - "Our results of a decreased risk of ER-PR- tumors in women with intermediate intake of coumestrol could be due to chance because of the low intake. "
05/01/2008 - "The risk of ER-PR- tumors was significantly lower (50%) in women with intermediate coumestrol intake compared with those who did not consume any. "
09/20/2012 - "The present study examined the hypothesis that coumestrol protects hippocampal neurons in ovariectomized rats in a model of cerebral global ischemia. "
03/01/2014 - "In this study, we investigated the possible mechanisms underlying the neuroprotective effects of coumestrol, a potent isoflavonoid with antioxidant activities and binding affinities for both estrogen receptors (ER) ER-alpha and ER-beta that are comparable to those of 17beta-estradiol, in a model of global ischemia in male subjects. "
03/01/2014 - "Wistar rats underwent global ischemia (10 minutes) or sham surgery and received a single intracerebroventricular (icv) infusion of 20 μg of coumestrol or vehicle 1 hour before ischemia or 0, 3, 6, or 24 hours after reperfusion. "
03/01/2014 - "Coumestrol treatment prevents Na+, K+ -ATPase inhibition and affords histological neuroprotection to male rats receiving cerebral global ischemia."
03/01/2014 - "The data analysis revealed an extensive neuronal death in the CA1 hippocampal subfield at 7 days, and a significant decrease in the Na+, K+ -ATPase activity at 1 and 24 hours after ischemia, and both injuries were attenuated by coumestrol administration. "
|7.||NF-kappa B (NF-kB)
|8.||Adenosine Triphosphatases (ATPase)
|2.||Homologous Transplantation (Allograft)