Corticosterone

An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)

Also Known As:

Networked: 4354 relevant articles (124 outcomes, 376 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Raff, Hershel: 21 articles (01/2022 - 01/2003)
2.	Palme, Rupert: 19 articles (01/2022 - 05/2006)
3.	Wang, Hui: 18 articles (07/2022 - 01/2014)
4.	Tufik, Sergio: 14 articles (08/2022 - 01/2007)
5.	Cohen, Hagit: 14 articles (06/2021 - 12/2007)
6.	Zohar, Joseph: 13 articles (06/2021 - 12/2007)
7.	Kaplan, Zeev: 12 articles (01/2019 - 12/2007)
8.	Meijer, Onno C: 11 articles (10/2021 - 03/2010)
9.	Herman, James P: 11 articles (01/2021 - 08/2004)
10.	Riddell, Michael C: 11 articles (08/2017 - 12/2004)

Related Diseases

1.	Body Weight (Weight, Body) 08/01/1991 - "The optimal dose of corticosterone (30 mg/kg of feed) was effective in maintaining postchallenge-exposure body weight greater than that of controls. " 12/01/2022 - "A daily dose of the extract for 28 days improved body weight gain and significantly reduced corticosterone levels of mice exposed to chronic unpredictable mild stress. " 01/01/2015 - "The relative efficacy of pre versus post administration of corticosterone and high versus low dose of corticosterone on stress-induced exaggeration of innate fear response and stress-retarded body weight growth indicate that exogenous corticosterone administration within an appropriate time window and dosage are efficacious in diminishing traumatic stress induced pathophysiological processes. " 11/01/2021 - "LBP treatment reduced offspring's plasma corticosterone level and improved their body weight, changed the emotional function, increased the diversity of gut microbiota. " 01/17/2014 - "Exposure to chronic scream sound suppressed body weight gain, increased corticosterone (CORT) level, influenced the morphology of adrenal gland, improved spleen and thymus indices, and decreased latency in MWM test. "
2.	Shock 06/22/1999 - "Plasma corticosterone levels in response to avoidable foot shock in the LH- rats were significantly greater than in the LH+ group. " 01/01/2015 - "To further examine the efficacy of corticosterone in treating hyperarousal and elevated fear, the present study utilized a learned helplessness stress model in which rats are restrained and subjected to tail shock for three days. " 01/01/2022 - "In a separate group of rats, the efficacy of the acute foot shock in triggering a stress response was confirmed wherein a comparable surge in circulating corticosterone was seen in all three experimental groups. " 10/01/2021 - "In the present study with Day-17 pups, one session of periorbital shock, the typical EBC unconditioned stimulus for young rat pups, resulted in lower plasma corticosterone levels and neural activity in the central nucleus of the amygdale (CeA) of pups returned to the mother and homecage following the session as compared to pups isolated following the shock session. " 07/01/2012 - "This study investigated whether neuronal modulation was induced in the amygdala after two kinds of stress, that is, such as electric shock and corticosterone injection. "
3.	Wounds and Injuries (Trauma) 10/01/2003 - "Using this approach there is evidence for improved welfare from increasing space in cages, based on reduced aggression, corticosterone concentrations and mortalities and increased production, and for incorporating perches, based on the reduction in injuries at depopulation. " 07/01/2021 - "The aim of the work was to study changes in the time range of heart rate variability (HRV) against the background of changes in the concentration of corticosterone in blood plasma in rats after surgical trauma to the nasal septum. " 01/01/2021 - "In our previous study, we found that prenatal trauma exposure leads to an anxiety phenotype in mouse pups, characterized by increased corticosterone levels and increased anxiety-like behavior. " 07/01/2014 - "In this study, we examined how bactericidal ability and corticosterone interacted by applying acute restraint stress in a non-model organism, the side-blotched lizard (Uta stansburiana), 10 days after receiving a cutaneous wound. " 11/01/2012 - "In contrast with other studies, the model of multiple ethological mild stressors utilized in this study significantly increased the levels of corticosterone, but failed to dramatically alter the healing of skin wounds. "
4.	Inflammation (Inflammations) 01/01/1993 - "We found no change of the plasma corticosterone level in 6-SAI-dosed animals, neither at the beginning of 6-SAI administration nor when the inflammation reached maximal values nor during the remission of paw swelling. " 01/01/2021 - "Studies in rodent models of depression show that some of them inhibit inflammation, decrease corticosterone level and change the level of neurometabolites, which consequently lead to mitigation of the symptoms of depression. " 09/01/2000 - "The hypothesis of this study was that food intake and diurnal corticosterone analysis can be used as indicators of adjuvant-induced TMJ inflammation. " 12/01/1988 - "In this study, we used euthymic and congenitally athymic mice on a BALB/c background to explore the role of T cells in controlling corticosterone levels and the leukocyte response to inflammation. " 11/15/2023 - "A combination of NP with inflammation occurring in the neonatal period might aggravate the adverse effects of each on somatosensory and cognitive development of rats, the mechanism of which might be associated with the increase of corticosterone secretion and the dysregulation of synaptic molecules."
5.	Neoplasms (Cancer) 03/01/2013 - "However, only the AWA protocol was effective in predicting the tumor size and the level of fecal corticosterone metabolites (FCM). " 12/14/2009 - "This study confirms that social stress has complex effects on immune system and tumor development that are not simply linked to corticosterone titers." 11/01/2008 - "In a lifespan study, female rats lived with their sisters and were tested for temperament, affiliative reciprocity during an everyday stressor at puberty, corticosterone response to a stressor, mammary tumor development and diagnosis, and death. " 10/20/2008 - "This study analyzed in Balb/C mice the effects of individual housing on behavior, serum corticosterone and resistance to Ehrlich tumor growth. " 01/01/1989 - "Additional studies are necessary to determine if the increase in serum levels of corticosterone alters other parameters of the host response to tumors. "

Related Drugs and Biologics

1.	Adrenocorticotropic Hormone (ACTH)
2.	Glucocorticoids
3.	Glucose (Dextrose)
4.	Cytokines
5.	Interleukin-6 (Interleukin 6)
6.	Antioxidants
7.	Hydrocortisone (Cortisol)
8.	Insulin (Novolin)
9.	Dexamethasone (Maxidex)
10.	Brain-Derived Neurotrophic Factor (BDNF)

Related Therapies and Procedures

1.	Adrenalectomy
2.	Therapeutics
3.	Transplantation
4.	Oral Administration
5.	Resuscitation