Coproporphyrins

Porphyrins with four methyl and four propionic acid side chains attached to the pyrrole rings. Elevated levels of Coproporphyrin III in the urine and feces are major findings in patients with HEREDITARY COPROPORPHYRIA.

Networked: 34 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bednarczyk, Dallas: 1 article (01/2016)
2.	Boiselle, Carri: 1 article (01/2016)
3.	Hanneken, S: 1 article (10/2009)
4.	Kochs, C: 1 article (10/2009)
5.	Mühlenstädt, E: 1 article (10/2009)
6.	Neumann, N J: 1 article (10/2009)
7.	Geier, David A: 1 article (08/2006)
8.	Geier, Mark R: 1 article (08/2006)
9.	Almeida, Hiram Larangeira de: 1 article (12/2005)
10.	Jacobo, Andréia: 1 article (12/2005)

Related Diseases

1.	Metrorrhagia (Spotting) 03/01/1989 - "A study was conducted on a total of 200 workers whose duties bring them into contact with lead, to determine levels of total alanuria, plumbemia and coproporphyrins in urine, basophil spotting and Burton's fringe. " 03/01/1989 - "Coproporphyrins were also high in more than 60% and also in more than 60% of cases, basophil spotting was found. "
2.	Porphyrias (Porphyria) 10/01/1993 - "The atypical coproporphyrins II and IV were detected in all types of porphyria analysed and ranged from 0.2 to 9.0%; no significant differences were seen between acute and chronic hepatic porphyrias. " 03/01/1999 - "The concentration of total coproporphyrins was about 30-fold increased in patients with ALAD deficiency porphyria and acute lead intoxication as compared with controls. " 11/01/1987 - "Biochemically elevated levels of protoporphyrins in erythrocytes, uroporphyrins in urine, and coproporphyrins in feces are markers of this form of porphyria. " 07/01/2000 - "We describe a cutaneous form of porphyria in a neonate presenting with severe liver failure due to tyrosinaemia type 1. This porphyria is tentatively attributed to a secondary accumulation of coproporphyrins due to cholestasis, as reported in the bronze baby syndrome and recently described in neonates with purpuric phototherapy-induced eruption, rather than to a primary defect of porphyrin metabolism. "
3.	Lead Poisoning (Poisoning, Lead) 12/01/1956 - "[Urinary secretion of coproporphyrins in lead poisoning. " 10/01/1956 - "[Acute accidental lead poisoning causing occlusive abdominal syndrome; diagnosis made by determination of urinary coproporphyrins]." 12/01/1954 - "[Use of Beckman's spectrophotometry in the determination of coproporphyrins in blood and urine in lead poisoning]." 04/01/1952 - "Urinary coproporphyrins in lead poisoning."
4.	Variegate Porphyria (Protoporphyrinogen Oxidase Deficiency) 07/01/1986 - "Examination of stools demonstrated an increase of protoporphyrins and coproporphyrins, with prevalence of the former, characteristic of porphyria variegata. " 10/01/2009 - "Porphyrin analysis in the third patient showed normal excretion of total urine porphyrins and precursors; however, fecal porphyrins were elevated with dominating coproporphyrins in HPLC and the plasma fluorescence scan yielded a peak at 625 nm. Subsequent mutation analysis showed a mutation in the protoporphyrinogen oxidase gene, thereby confirming the diagnosis of variegate porphyria. " 12/01/1967 - "1. The partition of uroporphyrins I and III, coproporphyrins I and III, haematoporphyrin IX, porphyrin c and a hydrophilic porphyrin-peptide fraction from variegate-porphyria faeces has been studied in systems of equal volumes of cyclohexanone and sodium acetate buffers of varying pH and concentration. "
5.	Hepatic Porphyrias (Hepatic Porphyria) 10/01/1993 - "The atypical coproporphyrins II and IV were detected in all types of porphyria analysed and ranged from 0.2 to 9.0%; no significant differences were seen between acute and chronic hepatic porphyrias. " 06/16/1983 - "The first of these is a dramatic acute neuroabdominal picture: the diagnosis of acute hepatic porphyria is established by the measurement of urinary porphyrins; the second step is to distinguish between the three acute hepatic porphyrias by looking for cutaneous manifestations and determining the respective proportions of coproporphyrins and protoporphyrins in the stools. " 09/01/1996 - "Coproporphyrins I and III, uroporphyrins I and III, and porphobilinogen, intermediates in the biosynthesis of heme that accumulate in hepatic porphyrias, are ineffective as inhibitors of the nitric oxide synthase isoforms. "

Related Drugs and Biologics

1.	Porphyrins
2.	Protoporphyrins
3.	Uroporphyrins
4.	Porphobilinogen
5.	Aminolevulinic Acid (Levulan)
6.	Acute Hepatic Porphyria
7.	Protoporphyrinogen Oxidase (Protox)
8.	Pregnancy-Associated alpha 2-Macroglobulins (alpha 2 Macroglobulin)
9.	Protein Isoforms (Isoforms)
10.	Sodium Acetate (Sodium Acetate, Anhydrous)

Related Therapies and Procedures

1.	Phototherapy (Light Therapy)