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Contusions

Injuries resulting in hemorrhage, usually manifested in the skin.
Also Known As:
Bruise; Bruises; Contusion
Networked: 1794 relevant articles (81 outcomes, 203 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Wounds and Injuries (Trauma)
2. Spinal Cord Injuries (Spinal Cord Injury)
3. Pain (Aches)
4. Cicatrix (Scar)
5. Brain Injuries (Brain Injury)

Experts

1. Stein, Donald G: 16 articles (08/2013 - 11/2002)
2. Fischer, Itzhak: 8 articles (09/2015 - 08/2005)
3. Raghavendran, Krishnan: 8 articles (10/2014 - 08/2005)
4. Unterberg, A W: 8 articles (07/2014 - 01/2000)
5. McTigue, Dana M: 8 articles (05/2014 - 04/2006)
6. Tetzlaff, Wolfram: 7 articles (04/2015 - 09/2007)
7. Bunge, Mary Bartlett: 7 articles (01/2014 - 01/2002)
8. Hoth, J Jason: 7 articles (04/2012 - 11/2005)
9. Shumsky, Jed S: 7 articles (03/2012 - 08/2005)
10. Dietrich, W Dalton: 7 articles (02/2012 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Contusions:
1. salicylhydroxamic acid (SHAM)IBA
2. CytokinesIBA
3. diclofenac hydroxyethylpyrrolidine (DIEP)FDA Link
4. Glutathione (Reduced Glutathione)IBA
06/01/2002 - "In the present study the effects of augmenting SC levels of the endogenous antioxidant glutathione (GSH) on LPO after SCI were studied in a rat contusion injury model. "
01/01/2013 - "Glutathione levels were significantly lower in the contusion group than in the control group and significantly higher in the contusion+DFX group. "
07/01/2014 - "In the current study we evaluated the efficacy of cell-permeating thiol, N-acetylcysteine amide (NACA), a precursor of endogenous antioxidant glutathione (GSH), on mitochondrial function acutely, and long-term tissue sparing and hindlimb locomotor recovery following upper lumbar contusion SCI. Some designated injured adult female Sprague-Dawley rats (n=120) received either vehicle or NACA (75, 150, 300 or 600mg/kg) at 15min and 6h post-injury. "
01/01/2005 - "To explore the neuroprotective effects of cell-permeable reduced glutathione monoethyl ester (GSHE), rats subjected to SC contusion using the New York University impactor were randomly assigned to receive intraperitoneally GSHE (total dose of 12 mg/kg), methylprednisolone sodium succinate (total dose of 120 mg/kg), or saline solution as vehicle. "
09/01/2011 - "In this study, we used a controlled weight-drop TBI model and found that brain contusion induced oxidative stress (a decreased level of total glutathione and an increased ratio of oxidized glutathione to total glutathione), a reduction in STAT1 DNA-binding activity, and consequently neuronal loss in a contusion depth-dependent manner. "
5. OxygenIBA
6. fingolimod (FTY720)FDA Link
7. Heparin (Liquaemin)FDA LinkGeneric
8. glucuronyl glucosamine glycan sulfate (Vessel)IBA
9. Troponin IIBA
10. Brain-Derived Neurotrophic Factor (BDNF)IBA

Therapies and Procedures

1. Transplants (Transplant)
2. Transplantation (Transplant Recipients)
3. Catheters
4. Aftercare (After-Treatment)
5. Oral Administration