Male Contraceptive Agents (Male Contraceptives)

11/01/2022 - "BET family members BRD4 and BRDT are validated targets for cancer and male contraceptive drug development, respectively. "
02/27/2020 - "It not only plays a critical role in development and self-protection of cotton plants, but also can be used as important anti-cancer and male contraceptive compound. "
02/01/2009 - "My current interests and my visions for the future include the following: (1) mass production of mature eggs and spermatozoa in vitro, (2) permanent sperm preservation at ambient temperature, (3) development of safer and more efficient assisted fertilization (reproduction) technologies, (4) development of safe and efficient methods of cloning, (5) production of artificial organs such as an artificial uterus, (6) development of safe and effective male contraceptives, and (7) prevention of cancer through germ cell research."
01/01/2017 - "The effect of Pin1 dosage in Sertoli cells might be useful in the study of toxicant-mediated infertility, gonadal cancer, and for designing male contraceptives."
10/01/1993 - "Gossypol, a polyphenolic compound extracted from cotton plants, shows promise for use as a male contraceptive, as well as a treatment for gynecological disorders, cancer, and certain microbial diseases. "

07/01/2000 - "Prototype hormonal male contraceptive regimens generally achieve only incomplete suppression to azoospermia with potentially adverse metabolic effects. "
03/01/1996 - "This is currently being investigated as a possible method of hormonal male contraceptive, but complete suppression of spermatogenesis to azoospermia is induced in only 50-70% of Caucasian men; the remainder maintain a low rate of spermatogenesis. "
03/01/1996 - "This is currently being investigated as a possible method of hormonal male contraceptive, but complete suppression of spermatogenesis to azoospermia is induced in only 50-70% of Caucasian men; the remainder maintain a low rate of spermatogenesis. "
04/01/1994 - "The emphasis on effecting complete azoospermia hinders development of male contraceptives. "
08/01/1992 - "In conclusion, the combined GnHR antagonist and T treatment can induce azoospermia in most men and has potential as a male contraceptive regimen."

07/01/1997 - "The study did not exclude the possibility that disorders of sperm function might occur when spermatogenesis is suppressed further to very severe oligozoospermia (< 1 x 10(6)/mL), commonly observed in hormonal male contraceptive clinical trials."
09/01/2008 - "Moreover, after switching medication, drug-induced asthenozoospermia was cured more rapidly than oligozoospermia, suggesting that further delineation of such differences may help to elucidate mechanisms of spermatogenesis and might facilitate the development of non-hormonal male contraceptive agents."
06/01/1995 - "To determine the ability of spermatozoa to bind to the zona pellucida (ZP) in testosterone-induced oligozoospermia, previously fertile men participating in the World Heath Organization (WHO) male contraceptive trial in Melbourne were studied while oligozoospermic to various degrees. "
06/01/1995 - "Ability of spermatozoa to bind to the zona pellucida during oligozoospermia induced with testosterone during a male contraceptive trial."
08/01/1997 - "Comparison between testosterone oenanthate-induced azoospermia and oligozoospermia in a male contraceptive study. "

10/01/1998 - " In order to assess the efficacy of a potential male contraceptive, it is important to determine what level of sperm inhibition is necessary to achieve infertility. "
11/01/2002 - "Results that makes PFEG hypotonic-like effect a serious candidate to conduct a study to determine the predicting capacity of this compound in human infertility and suggest that the plant may yield a compound suitable for use as male contraceptive agent."
10/01/2022 - "Since its initial publication, aimed at providing useful data in the evaluation of male contraceptive drugs, the manual has developed to focus mainly on discovering male factors of infertility as a basis for medical assisted reproduction. "
01/01/2020 - "These results provide the structural basis for the role of TEX101 in fertilization and could contribute to developing diagnostic methods and treatments for infertility or developing male contraceptives."
09/01/2015 - "Better understanding of the molecular mechanisms that mediate sperm capacitation can be used for infertility diagnosis, treatment and the developing of male contraceptives."

04/01/2009 - "The future studies of detailed molecular mechanisms in these in vivo animals with cell-specific AR knockout could possibly lead to useful insights for improvements in the treatment of male infertility, hypogonadism, and testicular dysgenesis syndrome, and in attempts to create safe as well as effective male contraceptive methods."
11/01/1998 - "This injectable TU preparation may provide improved substitution therapy for male hypogonadism and, in addition, may be developed as an androgen component of male contraceptives."
01/01/2002 - "Subcutaneously administered testosterone microcapsules may provide a safe and convenient method for the long-term treatment of male hypogonadism or testosterone replacement in male contraceptive regimens."