|4.||Condylomata Acuminata (Genital Wart)
|1.||Garland, Suzanne M: 6 articles (09/2015 - 06/2002)|
|2.||Castellsagué, Xavier: 6 articles (05/2015 - 08/2008)|
|3.||Markowitz, Lauri E: 6 articles (12/2013 - 04/2008)|
|4.||Dunne, Eileen F: 6 articles (12/2013 - 04/2008)|
|5.||Kahn, Jessica A: 5 articles (10/2013 - 10/2005)|
|6.||Huang, Zheng: 5 articles (05/2012 - 03/2006)|
|7.||Sings, Heather L: 4 articles (09/2015 - 11/2008)|
|8.||Haupt, Richard M: 4 articles (09/2015 - 07/2010)|
|9.||Brotherton, Julia M L: 4 articles (09/2015 - 09/2009)|
|10.||Stockfleth, Eggert: 4 articles (07/2014 - 11/2002)|
|1.||imiquimod (Aldara)FDA LinkGeneric
04/01/2001 - "When 5% imiquimod cream is applied three times a week up to 16 weeks, approximately two thirds of women treated with imiquimod achieve complete clearance of genital warts, whereas only about one third of men clear completely. "
09/01/2000 - "The study demonstrated that 2% imiquimod in cream with mild non-objective side effects is safe, tolerable and significantly more effective than placebo in curing external genital warts in males."
07/01/1998 - "In conclusion, the data presented demonstrate that 2% imiquimod in cream with mild to moderate subjective side effects is significantly more effective than placebo in eliminating genital warts in women."
04/01/1998 - "Patient-applied 5% imiquimod cream is effective for the treatment of external genital warts and has a favorable safety profile."
04/01/2009 - "Imiquimod is a topically used immune response modifier effective in the treatment of genital warts caused by HPV. "
11/01/1989 - "We consider the systemic treatment with interferon for condylomata acuminata to be highly effective and well tolerated. "
03/01/1994 - "Recently, studies have suggested that interferons would be effective in the treatment of some genital warts. "
10/23/1986 - "We conclude that injection of interferon alpha-2b directly into genital warts appears to be an effective and fairly well-tolerated form of therapy."
01/01/1998 - "Pilot studies of adjuvant therapy with topically applied interferons (IFN) have shown promising results in reducing the recurrence of condylomata acuminata (CA). "
06/01/1987 - "Interferons are proving useful in the management of recalcitrant condylomata acuminata. "
|3.||Podophyllotoxin (Condylox)FDA LinkGeneric
02/01/1995 - "In the therapeutic arsenal for the treatment of condylomata, podophyllotoxin 0.5% is a first line treatment for condylomata acuminata of the genital mucous membranes."
10/01/1990 - "Thus, 0.5% podofilox solution appears to be an effective treatment for condylomata acuminata, with acceptable side effects that are local and temporary."
12/01/1990 - "In conclusion podophyllotoxin 0.5% appeared to be safe and effective for the self treatment of genital warts."
01/01/1993 - "The purpose of this comparative open study was to determine the clinical efficacy of 0.3% podophyllotoxin both in 70% ethanolic solution and cream preparations on genital warts. "
12/01/1995 - "To evaluate the clinical efficacy of a 0.15% and a 0.3% cream formulation of podophyllotoxin in comparison with the 0.5% solution in the treatment of condylomata acuminata and to compare the treatment modalities regarding side effects. "
01/01/2013 - "In this study, we made an analytical comparison of the two vaccines in terms of cost-effectiveness including the additional benefits of cross-protection and protection against genital warts in comparison with a screening-only strategy. "
07/23/2009 - "The following paper represents a summary of the full-text version of the German evidence-based Guidelines, including all evidence-based recommendations regarding the safety as well as the efficacy of the vaccines in preventing CIN, VIN/VaIN, genital warts and other HPV-associated lesions."
10/01/2008 - "The aim of this work was to study the human papillomavirus (HPV) type-distribution in condylomata acuminata (CA) of mainland China and to estimate the potential role of HPV prophylactic vaccines for CA in mainland China. "
03/30/2006 - "Furthermore, phase 2 trials of a bivalent vaccine designed to protect against high-risk HPV types 16 and 18 and a quadrivalent vaccine designed to protect against HPV 16 and 18, and low-risk, genital wart-causing HPV 6 and 11 have demonstrated that VLP vaccines reduce the incidence of HPV-associated disease in vaccinated individuals. "
05/01/2015 - "Post-licensure country reports have shown the recent and early impact of these vaccines at population level after the implementation of established HPV vaccination programs, including decreases in the prevalence of vaccine HPV types, the incidence of genital warts, and the incidence of high-grade cervical abnormalities. "
|5.||type 6,11,16,18 human papillomavirus vaccine L1 (Gardasil)FDA Link
08/19/2008 - "Gardasil was also highly efficacious at preventing vaginal/vulvar lesions and genital warts. "
11/20/2012 - "Gardasil(®) also demonstrated strong protection against genital warts and vulvar/vaginal neoplasia associated with the vaccine types. "
02/01/2008 - "Data from the Phase III trial demonstrated that Gardasil was 100% effi cacious in preventing precancerous lesions of the cervix, vulva, and vagina and effective against genital warts. "
11/01/2010 - "The FDA recently approved the use of the HPV quadrivalent vaccine, Gardasil, for the prevention of genital warts in males ages 9 through 26. "
07/05/2010 - "GARDASIL has been shown to reduce the incidence of pre-cancerous cervical, vulvar, and vaginal lesions, and external genital warts causally related to HPV6/11/16/18. "
09/01/2010 - "We conclude that PDT can be considered a highly effective and safe treatment option for anogenital condylomata acuminata. "
10/01/2004 - "Results suggest that, compared with conventional therapies, topical ALA-PDT is a simple, effective, safe and well-tolerated treatment for urethral condylomata acuminata that is associated with a low recurrence rate. "
11/01/2003 - "Topical ALA-PDT is a potentially effective treatment for condylomata acuminata."
02/01/2011 - "This study, to the best of our knowledge, represents the first attempt to clarify the effect of ALA-PDT on infiltrating immune cells in condylomata acuminata. "
01/01/2015 - "Topical application of ALA-PDT is a simple and as effective therapy with a lower incidence of adverse effects in the treatment of condylomata acuminata."
|7.||Fluorouracil (Carac)FDA LinkGeneric
07/01/1987 - "It is concluded that weekly topical application of 5% 5-fluorouracil is well tolerated and highly effective in treating vaginal condylomata acuminata."
07/01/1990 - "I conclude that topical 5-FU is effective for treatment of vulvar condylomata acuminata and that periodic applications are preferable to continuous applications."
07/01/1982 - "Topical 5-FU helpful in reducing the rate of recurrence of condylomata acuminata."
01/01/2010 - "To determine the effectiveness and safety of 5-FU topical treatment for genital warts in nonimmunocompromised individuals. "
01/01/2010 - "5-FU for genital warts in non-immunocompromised individuals."
04/01/2009 - "Evidence suggests that green tea is effective for treating genital warts. "
11/01/2007 - "Polyphenon(R) E 15% ointment, composed of a defined green tea extract, proved to be efficacious and safe for both gender in the treatment of external genital warts."
03/01/2009 - "Two randomized trials evaluating the activity and efficacy of green tea catechins in the management of external genital warts are presented, and the reported side effects associated with this topical treatment modality are outlined. "
08/01/2011 - "This review describes the development of Polyphenon(®) E as a standardized green tea polyphenol preparation for many clinical trials and as an FDA-approved medication to treat genital warts. "
08/01/2015 - "For external genital warts, a topical ointment with green tea extracts was licensed in the USA in 2010, and recently also in Europe. "
|9.||Papillomavirus Vaccines (HPV Vaccines)IBA
07/01/2012 - "The aim of this study was to determine the cervical genotype profile of females who presented to an STI Clinic with external genital warts (EGW); and to determine the potential vaccine coverage prior to the uptake of the HPV vaccines. "
09/01/2015 - "HPV vaccines have had dramatic impacts on the prevalence of targeted HPV types (6,11,16 and 18), genital warts and precancerous cervical lesions. "
07/11/2013 - "Prophylactic HPV vaccines target young adolescents to prevent related cervical lesions and even genital warts prior to onset of sexual activity. "
08/01/2009 - "Cost of treatment and QALYs lost due to genital warts: data for the economic evaluation of HPV vaccines in the United Kingdom."
06/01/2008 - "One of the two new human papillomavirus (HPV) vaccines protects against HPV types 6 and 11, which cause over 95% of genital warts, in addition to protecting against HPV types 16 and 18. "
|10.||Interferon-alpha (Interferon Alfa)FDA Link
01/22/1988 - "Natural interferon alfa given intralesionally is an effective and safe treatment even in patients with recurrent or recalcitrant genital warts."
11/01/1988 - "This study demonstrates that parenterally administered Wellferon produces clearance of resistant genital warts in many patients, and that rates of clearance do not appear to vary between groups receiving moderate or low dose therapy."
11/01/1994 - "The purpose of this double-blind, placebo-controlled study was to determine and compare the clinical efficacy and tolerance of human leukocyte alpha-interferon (incorporated 2 x 10(6) IU/g) in hydrophilic cream to cure genital warts. "
11/01/1989 - "In the present study we used the well known antiviral properties of interferon alpha 2b in condylomata acuminata. "
05/01/1986 - "This study shows that systemic human lymphoblastoid interferon is active in treating severe recurrent genital warts in women with a history of recalcitrant disease."
|1.||Cryotherapy (Therapy, Cold)
11/01/2014 - "A single-blinded randomized controlled study to assess the efficacy of twice daily application of sinecatechins 15% ointment when used sequentially with cryotherapy in the treatment of external genital warts."
11/01/2014 - "To evaluate the efficacy of sequential therapy of cryotherapy and sinecatechins 15% ointment BID versus cryotherapy alone in treatment of external genital warts (EGW). "
03/01/1991 - "A clinical controlled study is presented for the treatment of condylomata acuminata with cryotherapy in 64 patients. "
03/01/1991 - "Cryotherapy in the treatment of condylomata acuminata: a controlled study of 64 patients."
03/01/2014 - "Cryotherapy is considered one of the most established treatments for genital warts. "
06/01/1985 - "The laser appears to be an effective method of treatment for recurrent or persistent condylomata acuminata provided that (1) the patient is not immunosuppressed, (2) the potentially infected sexual partner is examined and treated, if necessary, and (3) the external genitalia, including the anus, vagina and cervix, are carefully examined colposcopically to rule out the persistence of small lesions."
02/01/2015 - "A mucosal HPV type was found among 5.8% of employees with experience of laser treatment of genital warts as compared to 1.7% of those with no experience (p = 0.12). "
08/01/1998 - "Between October 1994 and March 1997, 6 men with rapidly recurrent external and intraurethral condylomata acuminata underwent BCG therapy after initial laser treatment. "
04/01/1996 - "Laser treatment of genital condylomata acuminata."
07/01/1994 - "[Laser applications in condylomata acuminata]."
|3.||Laser Therapy (Surgery, Laser)
07/01/1996 - "Laser therapy is widely accepted as a safe and effective means of treating genital condylomata acuminata. "
07/01/2010 - "This is a prospective study to assess a complementary treatment for genital warts after laser vaporization. "
02/01/1998 - "Two patients developed genital warts and were treated with laser vaporization. "
03/01/1995 - "The first results of laser therapy in treatment of condylomata acuminata of male reproductive organs are reported. "
04/01/1988 - "Some concerns about current laser surgery of condylomata acuminata."
01/01/1992 - "Therefore we consider cryosurgery a more refined technique in treatment of condylomata acuminata gigantea. "
01/01/1992 - "Two cases of condylomata acuminata gigantea treated with cryosurgery are described. "
01/01/1992 - "[Cryosurgery of condylomata acuminata gigantea--a contribution to therapy]."
03/01/1985 - "Therefore we consider cryosurgery the more refined technique in treatment of condylomata acuminata gigantea. "
03/01/1985 - "Three cases of condylomata acuminata gigantea were treated with cryosurgery. "
10/01/2004 - "In the univariate analysis, history of genital warts (P = 0.01), sexually transmitted disease (P = 0.001), premarital sexual intercourse (P = 0.002), sexual contact with a commercial sex worker (P = 0.003), being employed (P = 0.011) and having more than 10 injections for medical purposes (P = 0.006) all correlated with being HIV-infected. "
02/01/1990 - "This study design was to give 1 million units interferon alfa-2b intralesionally into the base of each of five external genital warts per patient, on a Monday-Wednesday-Friday treatment schedule for 3 weeks (total of nine injections). "
12/01/1990 - "These results suggest that in contrast to condylomata acuminata bowenoid papulosis lesions respond better to continuous than to intermittent interferon gamma injections."
05/12/1984 - "Intramuscular human interferon-beta injections in treatment of condylomata acuminata."
12/01/1979 - "Effect of injections of small doses of human fibroblast interferon into genital warts. "