HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

p-Methoxy-N-methylphenethylamine

A potent mast cell degranulator. It is involved in histamine release.
Also Known As:
Agent 48-80; BW 48-80; Compound 48-80; Preparation 48-80; Agent 48 80; Agent 4880; BW 48 80; BW 4880; Compound 48 80; Compound 4880; Preparation 48 80; Preparation 4880; p Methoxy N methylphenethylamine; Phenethylamine, p-methoxy-N-methyl-
Networked: 498 relevant articles (18 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Shin, Tae-Yong: 20 articles (05/2015 - 08/2002)
2. Kim, Sang-Hyun: 18 articles (05/2015 - 08/2002)
3. Kim, Hyung-Min: 15 articles (01/2014 - 01/2002)
4. Kim, H M: 12 articles (05/2012 - 01/2000)
5. Hong, Seung-Heon: 10 articles (01/2015 - 01/2002)
6. Shin, T Y: 9 articles (11/2013 - 01/2000)
7. Kim, Hui-Hun: 8 articles (05/2015 - 02/2011)
8. Jeong, Hyun-Ja: 8 articles (10/2014 - 10/2003)
9. Kim, Su-Jin: 7 articles (01/2015 - 01/2005)
10. Chai, Ok Hee: 7 articles (01/2014 - 10/2005)

Related Diseases

1. Edema
2. Hyperalgesia
3. Rhinitis
07/01/2003 - "Furthermore, NBGS significantly reduced in vitro histamine release from rat peritoneal mast cells triggered by compound 48/80 at concentrations of 30 and 100 microg/ml. These results suggest that NBGS may be clinically effective in alleviating the nasal symptoms of allergic rhinitis, probably by inhibiting both histamine release from mast cells and nasal vascular permeability."
10/11/2002 - "The action of compound 48/80 to release mast cell-derived histamine in the nose mimics many of the nasal responses associated with allergic rhinitis, extravascular leakage and decreased nasal patency. "
11/01/2000 - "Frequencies of pathological skin reactivity to single vasomotor agents and saline in the control group of healthy subjects and in the allergic rhinitis patients group are shown in Table 1. In the control group, frequencies of normal skin reactivity to papaverine [p(= 1.8 x 10(-7)) < 0.01], metacholine [p(= 4.3 x 10(-6)) < 0.01], histamine [p(= 4.3 x 10(-6)) < 0.01], compound 48/80 [p(= 1.8 x 10(-7) < 0.01] and saline [p(= 6.9 x 10(-4)) < 0.01] were significantly greater than frequencies of pathological skin reactivity. "
01/01/2002 - "These findings suggested that the pathological skin reactivity to papaverine, metacholine, histamine and compound 48/80 was a feature of chronic, non-infectious rhinitis patients and it was more frequently associated with non-allergic than with the allergic etiology of rhinitis."
01/01/2000 - "Seventy four perennial non-allergic rhinitis patients and fourty two healthy subjects were undergone to intradermal testing with papaverine (5 mg/ml), metacholine (0.02, 0.2 and 2.0 mg/ml), histamine (0.01, 0.1 and 10.0 micrograms/ml) and compound 48/80 (0.01, 0.1, 1.0 and 10.0 micrograms/ml). "
4. Anaphylaxis (Anaphylactic Shock)
5. Inflammation

Related Drugs and Biologics

1. Histamine (Histamine Dihydrochloride)
2. Bradykinin
3. Diphenhydramine (Benadryl)
4. Substance P
5. Methysergide (Sansert)
6. Antigens
7. Serotonin (5 Hydroxytryptamine)
8. Immunoglobulin E (IgE)
9. Dinoprostone (PGE2)
10. Latex

Related Therapies and Procedures

1. Intradermal Injections
2. Injections
3. Intravenous Injections
4. Intraperitoneal Injections
5. Oral Administration