|1.||Shin, Tae-Yong: 20 articles (05/2015 - 08/2002)|
|2.||Kim, Sang-Hyun: 18 articles (05/2015 - 08/2002)|
|3.||Kim, Hyung-Min: 15 articles (01/2014 - 01/2002)|
|4.||Kim, H M: 12 articles (05/2012 - 01/2000)|
|5.||Hong, Seung-Heon: 10 articles (01/2015 - 01/2002)|
|6.||Shin, T Y: 9 articles (11/2013 - 01/2000)|
|7.||Kim, Hui-Hun: 8 articles (05/2015 - 02/2011)|
|8.||Jeong, Hyun-Ja: 8 articles (10/2014 - 10/2003)|
|9.||Kim, Su-Jin: 7 articles (01/2015 - 01/2005)|
|10.||Chai, Ok Hee: 7 articles (01/2014 - 10/2005)|
01/01/2015 - "Additionally, Gc-FI (9 mg/kg, s.c.) inhibited Cg-induced edema in animals with intact mast cells but did not inhibit that with degranulated mast cells by compound 48/80, revealing a protective role on mast cell membranes. "
11/01/2012 - "AQP1 and AQP5 might play key roles in inflammatory subglottic edema caused by compound 48/80 in rats. "
11/01/2012 - "One hour after the compound 48/80 injection, the edema was diminished, but the inflammatory cell infiltration remained. "
11/01/2012 - "Aquaporin changes in compound 48/80 induced inflammatory sublaryngeal edema in rat."
09/01/2011 - "Anti-inflammatory activity was performed by compound 48/80 induced rat paw edema model and antipruritic activity by examining the incidence of scratching behavior. "
06/01/1999 - "We found that degranulation of mast cells with compound 48/80 relieved mechanical and thermal hyperalgesia produced by nerve damage. "
08/24/2012 - "Mast cell degranulation mediates compound 48/80-induced hyperalgesia in mice."
09/01/2015 - "Rat paws injected with compound 48/80, a mast cell degranulating agent, followed by Batroxase injection resulted in significant reduction of the edema and hyperalgesia. "
08/24/2012 - "Basic secretagogue compound 48/80 induced plantar mast cell degranulation accompanied by thermal hyperalgesia, tissue edema, and neutrophil influx in the hindpaws of ND4 Swiss mice. "
01/06/2006 - "But in the rats with compound 48/80 treatment for mast cell depletion, the Sar-SP-induced edema, but not hyperalgesia, was attenuated. "
07/01/2003 - "Furthermore, NBGS significantly reduced in vitro histamine release from rat peritoneal mast cells triggered by compound 48/80 at concentrations of 30 and 100 microg/ml. These results suggest that NBGS may be clinically effective in alleviating the nasal symptoms of allergic rhinitis, probably by inhibiting both histamine release from mast cells and nasal vascular permeability."
10/11/2002 - "The action of compound 48/80 to release mast cell-derived histamine in the nose mimics many of the nasal responses associated with allergic rhinitis, extravascular leakage and decreased nasal patency. "
11/01/2000 - "Frequencies of pathological skin reactivity to single vasomotor agents and saline in the control group of healthy subjects and in the allergic rhinitis patients group are shown in Table 1. In the control group, frequencies of normal skin reactivity to papaverine [p(= 1.8 x 10(-7)) < 0.01], metacholine [p(= 4.3 x 10(-6)) < 0.01], histamine [p(= 4.3 x 10(-6)) < 0.01], compound 48/80 [p(= 1.8 x 10(-7) < 0.01] and saline [p(= 6.9 x 10(-4)) < 0.01] were significantly greater than frequencies of pathological skin reactivity. "
01/01/2002 - "These findings suggested that the pathological skin reactivity to papaverine, metacholine, histamine and compound 48/80 was a feature of chronic, non-infectious rhinitis patients and it was more frequently associated with non-allergic than with the allergic etiology of rhinitis."
01/01/2000 - "Seventy four perennial non-allergic rhinitis patients and fourty two healthy subjects were undergone to intradermal testing with papaverine (5 mg/ml), metacholine (0.02, 0.2 and 2.0 mg/ml), histamine (0.01, 0.1 and 10.0 micrograms/ml) and compound 48/80 (0.01, 0.1, 1.0 and 10.0 micrograms/ml). "
|4.||Anaphylaxis (Anaphylactic Shock)
01/01/1989 - "In the present study we sought to develop a model of ocular anaphylaxis based on the topical application of compound 48/80 to the surface of the rat eye. "
01/01/2015 - "Moreover, the effect of ID on compound 48/80-induced anaphylactic shock was investigated in a mouse model. "
04/01/2014 - "Systemic anaphylaxis was induced by the injection of compound 48/80 into mice and their survival rate was monitored to evaluate the anti-allergic action of the extract. "
03/01/2014 - "Compound 48/80 was used as a direct mast cell degranulator to induce anaphylaxis. "
04/01/2013 - "The administration of C-HE prophylactically inhibited the systemic anaphylactic shock induced by compound 48/80 in mice. "
02/01/1981 - "Compound 48-80 may be helpful in evaluating the effects of therapeutic agents capable of modifying mast-cell degranulation and in the study of mediators involved in external ocular inflammation."
04/01/2015 - "Compound 48/80-treated HaCaT cells are a useful new in vitro model of skin inflammation."
01/01/2012 - "In this condition, we measured the paw-licking time by compound 48/80, but the suppression of time was not observed by the agent with or without the suppression of footpad inflammation. "
08/01/2004 - "Reciprocally, in vivo exposure of an ileal loop to the mast cell secretagogue compound 48/80 (0.2 mg/mL for 1 minute) induced muscular inflammation and delayed gastric emptying. "
03/01/2001 - "Opposite effects of mast cell degranulation by compound 48/80 on peritoneal inflammation in Swiss and CBA mice."
|1.||Histamine (Histamine Dihydrochloride)
|7.||Serotonin (5 Hydroxytryptamine)
|8.||Immunoglobulin E (IgE)