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Complement C5 (Complement 5)

C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.
Also Known As:
Complement 5; Complement Component 5; C5 Complement; Complement C5, Precursor; Precursor C5; Pro-C5; Pro-complement 5; C5, Complement; C5, Precursor; C5, Precursor Complement; Complement, C5; Component 5, Complement; Precursor Complement C5; Pro C5; Pro complement 5
Networked: 109 relevant articles (6 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Todaro, Thomas G: 7 articles (07/2011 - 09/2003)
2. Shernan, Stanton K: 5 articles (07/2011 - 03/2004)
3. Levy, Jerrold H: 4 articles (07/2011 - 08/2006)
4. Verrier, Edward D: 4 articles (07/2011 - 06/2005)
5. Adams, Peter X: 4 articles (07/2011 - 08/2006)
6. Chen, John C: 4 articles (07/2011 - 03/2004)
7. Rus, Horea: 4 articles (08/2009 - 09/2003)
8. Granger, Christopher B: 4 articles (08/2006 - 09/2003)
9. Mollnes, Tom E: 3 articles (03/2015 - 07/2013)
10. Carrier, Michel: 3 articles (07/2011 - 08/2006)

Related Diseases

1. Inflammation
2. Arthritis (Polyarthritis)
3. Hemolysis
4. End Stage Liver Disease
5. Thrombotic Thrombocytopenic Purpura

Related Drugs and Biologics

1. eculizumab
2. Complement System Proteins (Complement)
3. Atypical hemolytic uremic syndrome
4. Bilirubin
5. Alanine Transaminase (SGPT)
6. h5G1.1-scFv
7. Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
8. TNF Receptor-Associated Factor 1
9. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10. Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1. Cardiopulmonary Bypass (Heart-Lung Bypass)
2. Transplants (Transplant)
3. Coronary Artery Bypass (Coronary Artery Bypass Surgery)
4. Angioplasty (Angioplasty, Transluminal)
5. Coronary Balloon Angioplasty (Percutaneous Transluminal Coronary Angioplasty)