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Complement C3 Nephritic Factor

An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.
Also Known As:
C 3 Nephritic Factor; C3 Nephritic Factor; Complement 3 Nephritic Factor
Networked: 69 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Frémeaux-Bacchi, Véronique: 3 articles (02/2015 - 09/2011)
2. Roumenina, Lubka T: 2 articles (06/2015 - 08/2012)
3. Le Quintrec, Moglie: 2 articles (06/2015 - 08/2012)
4. Dragon-Durey, Marie-Agnès: 2 articles (06/2015 - 08/2012)
5. Moulin, Bruno: 2 articles (06/2015 - 08/2012)
6. Noël, Laure-Hélène: 2 articles (08/2012 - 09/2011)
7. Lesavre, Philippe: 2 articles (08/2012 - 09/2011)
8. Servais, Aude: 2 articles (08/2012 - 09/2011)
9. Licht, Christoph: 2 articles (09/2009 - 02/2009)
10. Jokiranta, T Sakari: 1 article (06/2015)

Related Diseases

1. Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II)
2. Lipodystrophy
3. Systemic Lupus Erythematosus (Libman-Sacks Disease)
4. Hemolysis
5. Glomerulonephritis

Related Drugs and Biologics

1. Autoantibodies
2. Complement Factor H (Factor H)
3. Agar
4. Complement System Proteins (Complement)
5. Immunoglobulin G (IgG)
6. Alternative Pathway Complement C3 Convertase
7. 1-dodecylpyridoxal (PLD)
8. Complement C3-C5 Convertases (C3 Convertase)
9. Properdin
10. Complement C3 (C3 Complement)

Related Therapies and Procedures

1. Plasmapheresis
2. Kidney Transplantation
3. Peritoneal Dialysis
4. Nephrectomy