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Complement C2 (Complement Component 2)

A component of the CLASSICAL COMPLEMENT PATHWAY. C2 is cleaved by activated COMPLEMENT C1S into COMPLEMENT C2B and COMPLEMENT C2A. C2a, the COOH-terminal fragment containing a SERINE PROTEASE, combines with COMPLEMENT C4B to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).
Also Known As:
Complement Component 2; C2 Complement; Complement 2; C2, Complement; Complement, C2; Component 2, Complement
Networked: 99 relevant articles (0 outcomes, 11 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Seddon, Johanna M: 3 articles (04/2016 - 09/2012)
2. Chakravarthy, Usha: 3 articles (09/2012 - 02/2009)
3. McKay, Gareth J: 3 articles (09/2012 - 02/2009)
4. Silvestri, Giuliana: 3 articles (09/2012 - 02/2009)
5. Allikmets, Rando: 3 articles (07/2011 - 04/2006)
6. Li, Xue-Jun: 2 articles (10/2020 - 01/2020)
7. Liu, Ying: 2 articles (10/2020 - 01/2020)
8. Ning, Gang: 2 articles (10/2020 - 01/2020)
9. Peng, Liang: 2 articles (10/2020 - 01/2020)
10. Wu, Li-Na: 2 articles (10/2020 - 01/2020)

Related Diseases

1. Macular Degeneration (Age-Related Maculopathy)
2. B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
3. Systemic Lupus Erythematosus (Libman-Sacks Disease)
4. Infections
5. Hereditary Complement Deficiency Diseases

Related Drugs and Biologics

1. Complement Factor B (Factor B)
2. Complement C2 (Complement Component 2)
3. Cyclophosphamide (Cytoxan)
4. ofatumumab
5. fludarabine
6. Complement Factor H (Factor H)
7. Complement C3 (C3 Complement)
8. Complement System Proteins (Complement)
9. Serine (L-Serine)
10. Peptide Hydrolases (Proteases)

Related Therapies and Procedures

1. Therapeutics