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Complement C1s (C1 Esterase)

A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).
Also Known As:
C1 Esterase; Complement Component 1s; C1s Complement; C 1 Esterase; Complement 1 Esterase; Complement 1s; C1s, Complement; Complement, C1s; Component 1s, Complement; Esterase, C 1; Esterase, C1; Esterase, Complement 1
Networked: 36 relevant articles (1 outcomes, 4 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Culley, Colleen M: 1 article (01/2016)
2. Wilson, Gregory L: 1 article (01/2016)
3. DiBridge, Julie N: 1 article (01/2016)
4. Likosky, Donald S: 1 article (09/2014)
5. Shore-Lesserson, Linda: 1 article (09/2014)
6. Hammon, John W: 1 article (09/2014)
7. Landis, R Clive: 1 article (09/2014)
8. Fitzgerald, David: 1 article (09/2014)
9. Baker, Robert A: 1 article (09/2014)
10. Brown, Jeremiah R: 1 article (09/2014)

Related Diseases

1. Hereditary Angioedemas
2. Reperfusion Injury
3. Hemolysis
4. Rheumatoid Arthritis
5. Angioedema

Related Drugs and Biologics

1. Factor XII (Hageman Factor)
2. Complement System Proteins (Complement)
3. Kallikreins (Kallikrein)
4. Antibodies
5. Complement C3-C5 Convertases (C3 Convertase)
6. Plasma Kallikrein
7. Nitric Oxide Donors
8. Leukocyte Elastase (Neutrophil Elastase)
9. Propofol (Diprivan)
10. Thrombin

Related Therapies and Procedures

1. Epidural Analgesia
2. Intradermal Injections