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Complement C1 (Complement 1)

The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.
Also Known As:
Complement 1; C1 Complement; Complement Component 1; C1, Complement; Complement, C1; Component 1, Complement
Networked: 66 relevant articles (1 outcomes, 5 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Chen, Wei: 2 articles (01/2015 - 04/2011)
2. Baeg, Gyeong Hun: 1 article (07/2015)
3. Salim, Agus: 1 article (07/2015)
4. Tan, Puay-Hoon: 1 article (07/2015)
5. Bay, Boon Huat: 1 article (07/2015)
6. Yu, Yingnan: 1 article (07/2015)
7. Thike, Aye Aye: 1 article (07/2015)
8. Matsumoto, Ken: 1 article (07/2015)
9. Scully, Olivia Jane: 1 article (07/2015)
10. Yip, George Wai-Cheong: 1 article (07/2015)

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1. Hereditary Angioedemas
2. Angioedema
3. Obesity
4. Systemic Lupus Erythematosus (Libman-Sacks Disease)
5. Peripheral Nervous System Diseases (PNS Diseases)

Related Drugs and Biologics

1. Bradykinin Receptors (Bradykinin Receptor)
2. Bradykinin
3. Complement System Proteins (Complement)
4. Decorin
5. Complement C4 (Complement Component 4)
6. Carrier Proteins (Binding Protein)
7. Complement C1 Inhibitor Protein (C1 Esterase Inhibitor)
8. Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
9. Immunoglobulin G (IgG)
10. Glial Fibrillary Acidic Protein

Related Therapies and Procedures

1. Emergency Treatment
2. Drug Therapy (Chemotherapy)