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Hereditary Nonpolyposis Colorectal Neoplasms (Hereditary Nonpolyposis Colorectal Cancer)

A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.
Also Known As:
Hereditary Nonpolyposis Colorectal Cancer; Colon Cancer, Familial Nonpolyposis; Syndrome, Lynch; Lynch Syndrome; Colorectal Neoplasms, Hereditary Nonpolyposis; Colorectal Cancer Hereditary Nonpolyposis; Hereditary Nonpolyposis Colon Cancer; Lynch Cancer Family Syndrome I; Lynch Syndrome I
Networked: 726 relevant articles (12 outcomes, 59 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Colorectal Neoplasms (Colorectal Cancer)
3. Microsatellite Instability
4. Endometrial Neoplasms (Endometrial Cancer)
5. Neurofibromatoses (Neurofibromatosis)

Experts

1. Kloor, Matthias: 20 articles (01/2014 - 05/2005)
2. Boland, C Richard: 19 articles (04/2012 - 02/2004)
3. Thibodeau, Stephen N: 17 articles (12/2015 - 07/2004)
4. Jenkins, Mark A: 16 articles (12/2015 - 09/2005)
5. Hopper, John L: 15 articles (12/2015 - 09/2005)
6. Lindor, Noralane M: 13 articles (12/2015 - 02/2004)
7. Castells, Antoni: 13 articles (05/2015 - 07/2006)
8. von Knebel Doeberitz, Magnus: 13 articles (01/2014 - 09/2006)
9. Syngal, Sapna: 12 articles (09/2015 - 02/2004)
10. Goel, Ajay: 12 articles (05/2015 - 06/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hereditary Nonpolyposis Colorectal Neoplasms:
1. N-methylsuccinimideIBA
2. Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
3. Biological Markers (Surrogate Marker)IBA
4. CalciumIBA
5. First StepIBA
6. Sulindac (Copal)FDA LinkGeneric
7. Cyclooxygenase 2 (Cyclooxygenase-2)IBA
8. celecoxib (Celebrex)FDA Link
9. DNA (Deoxyribonucleic Acid)IBA
10. Proteins (Proteins, Gene)IBA

Therapies and Procedures

1. Chemoprevention
2. Drug Therapy (Chemotherapy)
3. Urinary Diversion (Ileal Conduit)
4. Ileostomy
5. Colectomy