|3.||Crohn Disease (Crohn's Disease)
|4.||Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
|5.||Body Weight (Weight, Body)
|1.||Neurath, Markus F: 44 articles (07/2015 - 01/2002)|
|2.||Pothoulakis, Charalabos: 37 articles (10/2015 - 03/2003)|
|3.||Kanai, Takanori: 36 articles (09/2015 - 03/2003)|
|4.||Zarzuelo, Antonio: 36 articles (07/2015 - 11/2002)|
|5.||Kim, Dong-Hyun: 34 articles (12/2015 - 04/2008)|
|6.||Merlin, Didier: 31 articles (11/2015 - 07/2005)|
|7.||Watanabe, Mamoru: 30 articles (01/2014 - 03/2003)|
|8.||Sartor, R Balfour: 29 articles (10/2015 - 03/2002)|
|9.||Cuzzocrea, Salvatore: 28 articles (12/2015 - 07/2002)|
|10.||Tanaka, Takuji: 28 articles (05/2015 - 10/2003)|
05/01/2002 - "In conclusion, exogenous NO supplementation significantly ameliorates dextran sulfate sodium-induced colitis. "
11/01/2012 - "Here, we focus on the therapeutic efficacy of IL-1β-primed MSCs in the dextran sulfate sodium (DSS)-induced colitis model, in addition to the underlining mechanisms. "
11/01/2012 - "STW 5 is effective in dextran sulfate sodium-induced colitis in rats."
10/01/2005 - "The therapeutic value of SOD1 when administered prophylactically was assessed in the dextran sulfate sodium model of colitis with similar positive results. "
10/01/2002 - "Repeated colitis was induced by nine administration cycles of 3% dextran sulfate sodium (DSS; molecular weight, 54 000): each administration cycle comprised 3% DSS for 7 days followed by distilled water for the subsequent 14 days, to give conditions similar to the clinically observed active and remission phases in humans. "
|2.||Dextrans (Dextran)FDA Link
01/01/2014 - "Mouse colitis was induced by oral 2% dextran-sulphate (DSS) for 10 days. "
01/01/2014 - "denudation of the mucus layer associated with oral dextran sulphate in rodents, induces colitis. "
11/01/2013 - "Feces for bile acid analysis were collected after 3-wk feeding, followed by induction of dextran DSS colitis (2 d 5% DSS in drinking water + 2 d tap water). "
11/01/2007 - "AQP3 null mice given dextran sulphate developed severe colitis after 3 days, with colonic haemorrhage, marked epithelial cell loss and death. "
08/01/2004 - "Wild-type mice and mice heterozygous and homozygous for CFTR mutations were given dextran orally for 14 days to induce colitis. "
|3.||Mesalamine (Mesalazine)FDA LinkGeneric
05/01/2005 - "The colitis score improved similarly in both patient groups (by 2.3 with Ipocol and by 1.5 with Asacol: not significant), and a similar proportion was in clinical remission at the end of the study (26.1% for Ipocol and 28.6% for Asacol: not significant). "
09/01/1999 - "These studies show that an NO-releasing derivative of mesalamine has significantly enhanced anti-inflammatory activity, including improved efficacy in a rat model of colitis. "
07/28/2015 - "Furthermore, we confirmed a significant reduction of disease activity and a robust dose response efficacy following RNP(O) treatment in acute DSS-induced colitis mice, outperforming the positive control 5-aminosalicylic acid. "
11/01/2014 - "We screened 119 patients with UC in remission on the basis of Simple Clinical Colitis Activity Index scores, FC >50 μg/g, and intake of no more than 3 g/day mesalamine. "
04/01/2007 - "Mesalamine is the first-line therapy for colitis, but it lacks potency and is only effective for mild-to-moderate forms of this disease. "
|4.||sodium sulfate (sodium bisulfate)FDA LinkGeneric
01/01/2012 - "However, when Villin-Klf5 mice were treated with dextran sodium sulfate (DSS) to induce colitis, they developed less colonic injury and significantly reduced disease activity scores than littermate controls. "
06/01/2009 - "Human purified anti-S1P(1) Abs decreased mouse blood lymphocyte levels by a mean of 72%, suppressed mouse T-cell chemotaxis to S1P in vivo, and significantly reduced the severity of dextran sodium sulfate-induced colitis in mice. "
02/15/2015 - "The purpose of this study was to investigate the protective effects of pBD2 on mucosal injury and the disruption of the epithelial barrier during the pathological process of dextran sodium sulfate (DSS)-induced colitis. "
01/01/2014 - "Here, we studied the mechanisms underlying the protective effects of Lb CNRZ327 in vivo, in a mouse dextran sodium sulfate (DSS) colitis model. "
05/15/2013 - "In the present study, we examined the efficacy of an MCH-blocking antibody in treating established, dextran sodium sulfate-induced experimental colitis. "
|5.||Interleukin-10 (Interleukin 10)IBA
02/01/2014 - "These data demonstrate that chronic supplementation with a natural mineral extract selectively ameliorates spontaneous mild-moderate colitis in Il10(-/-) mice on a C57BL/6 J, but does not attenuate more moderate-severe colitis in BALB/c strain animals."
01/01/2010 - "The aim of this study was to determine if administration of cis-UCA would be effective in attenuating colitis and the possible role of IL-10. "
08/01/2004 - "This study investigates the therapeutic efficacy of an adenovirus encoding IL-10 (AdvmuIL-10) in the treatment of experimental colitis. "
12/01/2002 - "This study investigates the therapeutic efficacy of an adenoviral vector encoding IL-10 (AdvmuIL-10) in experimental colitis. "
02/01/2009 - "We hypothesized that interleukin-10 delivery to the distal gastrointestinal tract using a unique delivery vehicle may serve as a novel therapeutic for the treatment of experimental colitis. "
|6.||Acetic Acid (Vinegar)FDA LinkGeneric
04/01/2002 - "The protective effects of natural honey against acetic acid-induced colitis were investigated in rats. "
04/01/1991 - "Fish oil-enriched diet is mucosal protective against acetic acid-induced colitis in rats."
10/01/2010 - "The aim of this study was to evaluate the in vivo efficacy of this conjugate against acetic acid-induced colitis in rats. "
01/01/2015 - "Moreover, dietary supplementation with NAC ameliorates acetic acid-induced colitis in a porcine model. "
02/01/2011 - "The efficacy of the desired formulation was also evaluated against acetic acid-induced colitis in rats. "
07/01/2006 - "A significant improvement was observed in DAI score and histologic severity as well as in mucosal tissue levels of inflammatory cytokines, 8-OHdG, and MDA of mice treated with the EC-SOD gene as compared with those without gene therapy, not only in a mild colitis model but also in a severe colitis model. "
08/01/2009 - "In summary, we have demonstrated that both oral and locally administered Am possess protective effects against experimental colitis through differential modulation of colonic cytokines. "
01/01/2015 - "These results suggest that treatment with MMF may improve experimental colitis and induce inflammatory response remission of CD by down-regulation of pro-inflammatory cytokines via modulation of the differentiation of Th1/Th2 cells. "
01/01/2015 - "Perilla frutescens extract ameliorates DSS-induced colitis by suppressing proinflammatory cytokines and inducing anti-inflammatory cytokines."
07/01/2014 - "Camel's milk ameliorates TNBS-induced colitis in rats via downregulation of inflammatory cytokines and oxidative stress."
02/01/2014 - "DSS-induced colitis clearly induced Myeloperoxidase activity in the colon, which was significantly reduced by treatments with 3% DSS-pGLP-2 or 3% DSS-PEG-pGLP-2. These results showed that site-specific Lys(30)-PEG-GLP-2 was resistant to degradation and reduced the severity of colonic injury in murine colitis. "
01/01/2007 - "Both probiotics showed intestinal anti-inflammatory effects in this model of experimental colitis, as evidenced histologically and by a significant reduction of colonic myeloperoxidase activity (P<0.05). "
02/01/2006 - "Histologic scores of colonic damage and myeloperoxidase activity were lower in both probiotic-treated groups compared with those of the colitis control group (P<0.001), although the mentioned scores improved significantly more in the high-EPS group than in the low-EPS group (P<0.001). "
05/28/2014 - "The results indicated that the dietary incorporation of Salecan attenuated the severity of DSS colitis as evidenced by the decreased disease activity index, reduced severity of anaemia, attenuated changes in colon architecture and reduced colonic myeloperoxidase activity. "
03/01/2011 - "The macroscopical and histological scoring systems, wet colon mass index and myeloperoxidase activity were assessed to evaluate the efficacy of the capsule after administered orally to experimental colitis mice. "
11/01/2014 - "Safety and activity of dersalazine sodium in patients with mild-to-moderate active colitis: double-blind randomized proof of concept study."
04/01/2007 - "Our aim was to compare the localization of endogenous TFFs and binding sites for injected TFF3 in the colon of healthy and colitic mice and to study the effect of TFF3 on dextrane sulfate sodium (DSS)-induced colitis in mice. "
07/01/1999 - "Aim of this study was to assess the structural, ultrastructural, immunohistochemical, and clinical aspects in Sprague-Dawley rats with dextrane sulfate sodium (DSS)-induced colitis. "
01/01/2015 - "Colitis was induced by Dextransulfate-Sodium-Salt (DSS) in drinking water. "
10/01/2014 - "Furthermore, we showed LXR expression to be increased in vivo in dextrane sulphate sodium-induced colitis. "
|10.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
04/01/2010 - "Intracolonic administration of the gal-LMWC/ASO complex resulted in the successful delivery of ASO into activated colonic macrophages and a significant reduction of colonic TNFalpha in mice with colitis. "
02/01/2009 - "The present study further supports the role of oxidative/nitrosative stresses and TNF-alpha in the pathogenesis of colitis and protective effects of this herb. "
01/01/2006 - "The aim of the study was to investigate the effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats. "
11/01/2005 - "This study examined the expression of A2bR during colitis and studied effects of TNF-alpha on A2bR expression, signaling and function. "
12/21/2001 - "The study was designed to investigate whether colitis induced by trinitrobenzene sulphonic acid (TNBS) in rats produces an increase in TACE activity and/or expression and whether its pharmacological inhibition reduces TNF-alpha levels, iNOS expression and colonic damage in this model. "
01/01/2015 - "Daily oral administration of NZ-HO significantly improved these colitis-associated symptoms. "
04/01/2014 - "Oral administration of IAP significantly reduced the severity of colitis and down-regulated colitis-induced IκBα phosphorylation in IL-10(-/-) mice. "
04/01/2015 - "Anti-TNF-α therapies have shown protective effects against colitis, but an efficient tool for target suppression of its secretion - ideally via oral administration - remains in urgent demand. "
02/01/2011 - "Oral administration of LP was effective in the treatment of colitis, with the direct modification of gut microflora in IL-10(-/-) mice. "
01/01/2014 - "Interestingly, oral administration of immune milk partially improved the acute colitis induced by DSS. "
02/01/2007 - "Some cases of diversion colitis respond to treatment with short-chain fatty acid enemas; however, return of the fecal stream is the most successful therapy. "
12/01/1992 - "Restoration of the fecal stream cures diversion colitis, which in some cases may be successfully treated with short-chain fatty acid enemas, although the efficacy of this method remains to be substantiated. "
06/01/1995 - "The present study confirms that irrigation with SCFA enemas is effective in distal colitis, and may represent an alternative therapeutic tool in the treatment of the disease."
05/07/2011 - "GL-p enema has a therapeutic effect on experimental colitis in rats and may be useful in the treatment of UC."
08/01/2013 - "5-ASA enema appears to be both safe and effective in the treatment of diversion colitis following intestinal tract surgery. "
01/01/2004 - "Long-term results confirm high efficacy of total colectomy in severe nonspecific ulcerous colitis both in children and adults."
07/01/2013 - "It is unclear whether colectomy for fulminant Clostridium difficile colitis (FCDC) leads to a improvement in survival compared with continued medical therapy for this moribund population. "
12/01/2014 - "This study aimed to determine the safety of laparoscopic subtotal colectomy in severe colitis and to determine whether the laparoscopic approach improved short-term outcomes in comparison with the open approach. "
03/01/2009 - "Early colectomy may be associated with improved survival in fulminant Clostridium difficile colitis: an 8-year experience."
05/10/1990 - "Nine of the patients with severe colitis went into remission on medical therapy and 11 were operated on by colectomy. "
04/01/2005 - "Rectal administration of hrbFGF significantly improved the survival rate of mice with TNBS-induced colitis and partially ameliorated colitis. "
05/23/2003 - "The aim of our study was to evaluate the therapeutic efficacy of in vivo inhibition of PARP in experimental colitis, which was induced by rectal instillation of trinitrobenzene sulfonic acid (TNBS) in rats. "
01/01/2015 - "Rectal administration of PCT, which simulates the therapeutic action of colon-targeted PCT, also ameliorated rat colitis and reproduced the molecular effects in the inflamed colonic tissues. "
01/01/2015 - "Colitis was induced by a rectal instillation of TNBS at 0.1 mL per mouse. "
01/01/2015 - "In BALB/c mice, acute colitis was induced by intra-rectal administration of one dose TNBS, while chronic colitis was induced by administration of TNBS once a week for 7 weeks. "
|5.||Transplantation (Transplant Recipients)
08/01/2015 - "The transient high n-6-induced protection against colitis was fat type- and dietary reversal-dependent and could be transferred to germ-free mice by fecal microbiota transplantation. "
06/01/2015 - "We report a case in which fecal microbiota transplantation (FMT) utilized for relapsing Clostridium difficile colitis successfully eradicated colonization with several multidrug-resistant organisms (MDROs). "
09/01/2005 - "Early and rapid colonoscopy is beneficial for the early diagnosis and management of CMV colitis in transplant recipients."
05/01/2013 - "This study aimed to evaluate the therapeutic efficacy of transplantation of G-MDSC subsets from normal mice to colitis mice. "
08/01/2015 - "For example, fecal microbiota transplantation (FMT) from healthy individuals was remarkably effective in cases of refractory Clostridium difficile colitis. "