Colic (Abdominal Cramps)

A clinical syndrome with intermittent abdominal pain characterized by sudden onset and cessation that is commonly seen in infants. It is usually associated with obstruction of the INTESTINES; of the CYSTIC DUCT; or of the URINARY TRACT.

Also Known As:

Networked: 2718 relevant articles (166 outcomes, 250 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Colic (Abdominal Cramps)
3.	Cholelithiasis
4.	Vomiting
5.	Nausea

Experts

1.	Savino, Francesco: 13 articles (01/2021 - 04/2002)
2.	Proudman, C J: 11 articles (10/2020 - 06/2000)
3.	Nieto, Jorge E: 11 articles (04/2020 - 01/2005)
4.	Gilani, Anwarul Hassan: 8 articles (05/2016 - 10/2005)
5.	Archer, Debra C: 7 articles (04/2022 - 08/2006)
6.	Archer, D C: 7 articles (01/2019 - 08/2011)
7.	Vandenplas, Yvan: 7 articles (01/2019 - 01/2015)
8.	Mair, T S: 7 articles (09/2014 - 07/2005)
9.	Gehlen, Heidrun: 6 articles (01/2021 - 10/2019)
10.	Blikslager, A T: 6 articles (11/2020 - 06/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Colic:

1.	Analgesics (Analgesic Drugs)IBA 07/01/2002 - "The method described is reproducible and highly controllable method for inducing colic that involved duodenal distention that should be useful in evaluating the efficacy of various analgesic strategies. " 09/01/2006 - "The tests of Koster in the mouse and the "Tail Flik" in the rat showed that the global extracts of the studied species have all two greatly peripheral analgesic activity with an important protection against abdominal cramp 67.91% and 75.53% for 60 mg/kg IP respectively for Nepeta atlantica and Nepeta tuberosa L. " 09/01/2006 - "The tests of Koster in the mouse and the "Tail Flik" in the rat showed that the global extracts of the studied species have all two greatly peripheral analgesic activity with an important protection against abdominal cramp 67.91% and 75.53% for 60 mg/kg IP respectively for Nepeta atlantica and Nepeta tuberosa L. " 10/01/1992 - "A double blind randomized study was conducted in 52 patients with renoureteric colic to compare the therapeutic efficacy of two analgesics given in a single intramuscular dose. " 11/01/2017 - "Sexual intercourse also reduces the need for analgesics in ureteric colic due to ureteral stones."
2.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 09/09/2016 - "NSAIDs have been assessed in relatively few trials including a limited number of participants for biliary colic, considering its common occurrence. " 09/09/2016 - "Randomised clinical trials recruiting participants presenting with biliary colic and comparing NSAIDs versus no intervention, placebo, or other drugs. " 06/01/2012 - "Data from randomised clinical trials (RCTs) comparing NSAIDs with no treatment, placebo or other drugs in patients with biliary colic, were collected from Medline and Embase. " 07/01/1997 - "Follow-up was limited in previous studies, and the role of NSAIDs in the natural history of biliary colic has not been clarified. " 11/01/2020 - "Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to manage a wide variety of conditions in horses, including management of colic. "
3.	SimethiconeFDA Link 02/24/2021 - "breve CECT7263 is a safe and effective treatment for infantile colic, presenting an earlier and more robust effect than the reference prescribed drug, simethicone." 01/01/2012 - "To compare the efficacy of Mentha piperita with simethicone in treatment for infantile colic. " 01/01/2007 - "reuteri improved colicky symptoms in breastfed infants within 1 week of treatment, compared with simethicone, which suggests that probiotics may have a role in the treatment of infantile colic." 07/01/1994 - "To determine the efficacy of simethicone in the treatment of infant colic. " 01/01/1988 - "The efficacy of simethicone (available in liquid form as Mylicon Drops) in the treatment of infant colic was assessed in 51 healthy infants between 2 and 12 weeks of age. "
4.	Parasympatholytics (Antispasmodics)IBA 11/02/1978 - "In 70% of patients, treated by this new antispasmodic preparation, most symptoms, related to the irregular activities of the lower alimentary tract--as abdominal cramps and distrubance of bowel habit--improved. " 05/01/1983 - " 1 week before admission colic-like pains appeared in right upper abdominal quadrant which were relieved by spasmolytics. " 05/01/1960 - "[Study of a new spasmolytic of predominately musculotropic action in the treatment of nephretic colic]." 07/15/1967 - "[On the spasmolytic and antiphlogistic action of propaxoline in hepatic colic of surgical importance]." 05/05/1966 - "[Antispasmodic treatment in biliary and colic diseases (apropos of 50 clinical cases)]."
5.	Anti-Bacterial Agents (Antibiotics)IBA 02/12/2021 - "GM manipulation with oral antibiotics with mechanical bowel preparation still has uncertain benefits in right-sided colic resection but is very promising for left-sided colic resection. " 10/01/2020 - "Neonatal antibiotics and infantile colic in term-born infants." 01/01/2019 - "Preterm delivery and neonatal use of antibiotics in the first months of life are associated with an increased incidence of FGIDs, particularly infantile colic and regurgitation. " 01/01/2018 - "Since intrapartum antibiotic exposure may have an effect on early gut colonization, our finding is consistent with the association between aberrant early gut microbiota composition and development of colic. " 01/01/2018 - "The association between exposure to intrapartum antibiotics and infantile colic remained statistically significant after adjusting for potential confounding factors. "
6.	Diclofenac (SR 38)FDA LinkGeneric 07/01/1997 - "Treatment of biliary colic with diclofenac: a randomized, double-blind, placebo-controlled study." 04/07/1984 - "Diclofenac sodium in biliary colic: a double blind trial." 03/01/2018 - "Patients were asked to use 50 mg diclophenac Na on colic episode. " 10/01/2011 - "Treatment with diclofenac sodium during a relatively long period of reversible unilateral ureteric obstruction, similar to its use in the management of ureteric colic, appears to ameliorate the alterations in the hemodynamic glomerular functions at least 2 weeks following the reversal of obstruction." 04/05/2002 - "These results may provide good clinical evidence showing the value of diclofenac for the treatment of biliary colic. "
7.	Dicyclomine (Bentyl)FDA LinkGeneric 07/01/2006 - "While dicyclomine has been shown to be effective for colic, there are significant concerns about its safety, and the manufacturer has contraindicated its use in this population. " 06/01/1984 - "Dicyclomine eliminated colic in 15 of 24 (63%) infants, whereas placebo was effective in six of 24 (25%) (corrected X2 = 5.42, P = 0.02). " 01/01/1977 - "Evaluation of the efficacy of dicyclomine hydrochloride ('Merbentyl') syrup in the treatment of infant colic." 10/11/2011 - "90 otherwise healthy 2-8 weeks old infants, born after gestational week 36, fulfilling the criteria for infantile colic and not medicated with dicyclomine, were included. " 07/01/2003 - "Dicyclomine hydrochloride is the only pharmacological treatment for infantile colic that has been consistently effective. "
8.	KetorolacIBA 03/01/1997 - "IV ketorolac for the treatment of ureteral and biliary colic." 01/01/2017 - "[Management of ureteric colic with ketorolac and nifedipin vs. ketorolac and tamsulosin in the emergency room]." 10/01/2002 - "Comparison of intravenous ketorolac and meperidine in the treatment of biliary colic." 10/01/2003 - "In the patients with renal colic the average resistive index (RI) was significantly greater on the side of the colic after administration of either indomethacin or ketorolac (p<0.001). " 08/01/2008 - "This study evaluates the efficacy of IV ketorolac compared to butorphanol for the treatment of biliary colic pain in the ED. "
9.	Morphine (MS Contin)FDA LinkGeneric 12/01/2013 - "One horse receiving morphine developed post-operative colic and pulmonary oedema and two showed box-walking behaviour. " 07/01/2006 - "Multivariable logistic regression analysis was used to examine the association between post anaesthetic colic and explanatory variables, including use of perianaesthetic morphine. " 07/01/2006 - "To identify risk factors for development of colic following GA for magnetic resonance imaging (MRI) or nonabdominal surgery and to test whether the use of perianaesthetic morphine was associated with an increased risk of post anaesthetic colic. " 07/01/2006 - "Risk factors for colic in horses after general anaesthesia for MRI or nonabdominal surgery: absence of evidence of effect from perianaesthetic morphine." 01/01/1986 - "They have observed: a +/- 50% reduction of the quantity of morphine used; a +/- 50% reduction of the time required for peristaltic resumption; a +/- 50% reduction of the time required for gastric intubation thereby contributing to carefree post-operation effects in colic surgery where a series of known complications are usually to be expected. "
10.	Dipyrone (Metamizole)IBA 01/10/2019 - "Clinically, it has been demonstrated that dipyrone is effective in the control of colic-like abdominal pain originating from the biliary and intestinal tracts. " 05/01/2018 - "Metamizole is primarily used for severe perioperative pain, acute injury and colic, and cancer pain. " 04/20/2016 - "Dipyrone (metamizole) is a nonsteroidal anti-inflammatory drug used in some countries to treat pain (postoperative, colic, cancer, and migraine); it is banned in other countries because of an association with life-threatening blood disorders. " 09/08/2010 - "Dipyrone (metamizole) is a non-steroidal anti-inflammatory drug used in some countries to treat pain (postoperative, colic, cancer, and migraine); it is banned in others because of an association with life-threatening blood agranulocytosis. " 01/01/2023 - "Butylscopolamine is the second most frequently provided medication after Metamizole for "visceral colic-like pain" (55.8%). "

Therapies and Procedures

1.	Therapeutics 01/01/2013 - "It is a frequent source of consultation with healthcare professionals and is associated with high levels of parental stress and anxiety.(1,2) Several published reviews of the literature have explored dietary, pharmacological, complementary and behavioural therapies as options for the management of infantile colic.(1,3) Here, we assess whether these management options are supported by the literature and if there are any novel treatment options." 01/01/2010 - "The diagnosis and therapy planning of high prevalence pathologies such as infantile colic can be substantially improved by statistical signal processing of activity/rest registries. " 11/16/2023 - "Improved stone QOL may be an indication of alpha-blocker therapy in patients with ureteral stone colic." 01/01/2022 - "Our study, the Therapeutic Interventions for Stones of the Ureter trial, was designed to establish if treatment for ureteric colic should start with telescopic surgery or shockwave therapy. " 03/01/2021 - "Further study of the complementary and alternative therapy methods will help to increase the evidence for their effective use in the treatment of infantile colic."
2.	Cholecystectomy 05/01/1994 - "We conclude that cholecystectomy is superior to ESWL in improving biliary colic and fatty food upset. " 02/01/2022 - "EUS is a very useful technique for the indication of cholecystectomy in patients with minilithiasis/sludge and typical symptoms of biliary colic." 05/01/1994 - "Biliary colic was cured in 90.9% and 45.4% of the patients within 3 months after cholecystectomy or ESWL, respectively (p < 0.01). " 01/01/2021 - "The purpose of this study is to evaluate the response of patients with biliary colic and hyperkinetic gallbladder to cholecystectomy. " 01/01/2019 - "The aim of our study was to evaluate the outcomes following cholecystectomy on patients with biliary colic associated with hyperkinetic gallbladder. "
3.	Laparoscopic Cholecystectomy 01/01/2019 - "Patients with biliary colic and hyperkinetic gallbladder respond favorably to laparoscopic cholecystectomy. " 01/01/2021 - "The purpose of this study was to determine the effectiveness of early laparoscopic cholecystectomy in children with biliary colic. " 09/01/2006 - "The aim of this study was to compare the changes in generic HRQL observed before and after SVS for CEAP clinical grade 2 to 4 venous disease with those observed before and after elective laparoscopic cholecystectomy (ELC) for biliary colic. " 01/01/2005 - "The aim of this study was to compare the possible advantages and safety of urgent laparoscopic cholecystectomy (ULC) with elective laparoscopic cholecystectomy (ELC) in patients with biliary colic. " 01/01/2023 - "Recurrent biliary colic following laparoscopic cholecystectomy secondary to duplication gallbladder."
4.	Lithotripsy (Extracorporeal Shockwave Lithotripsy) 01/01/2019 - "To determine the efficacy of early extracorporeal shockwave lithotripsy (e-ESWL) in colic patients with ureteral stones and the patient criteria for the most effective e-ESWL. " 10/01/2018 - "The aim of this study was to assess the efficacy of emergency extracorporeal shockwave lithotripsy (eSWL) as first-line treatment in patients with acute colic due to obstructive ureteral stone. " 08/01/2023 - "Evaluation of safety, efficacy, and feasibility of emergency extracorporeal shockwave lithotripsy (eESWL) in combating obstructing stones with colic on emergency basis. " 01/01/2019 - "In case of colic due to ureteral stones, the patient is recommended to receive a lithotripsy within the first 24 hours. " 05/01/1996 - "The authors used extracorporeal lithotripsy for fragmentation of the stone and colic relief in 68 patients. "
5.	Musculoskeletal Manipulations (Manipulative Therapy) 12/12/2012 - "This found that a greater proportion of parents of infants receiving a manipulative therapy reported clinically significant improvements than did parents of those receiving no treatment (reduction in crying to less than two hours: odds ratio (OR) 6.33; 95% CI 1.54 to 26.00; more than 30% reduction in crying: OR 3.70; 95% CI 1.15 to 11.86).Analysis of data from three studies that measured 'full recovery' from colic as reported by parents found that manipulative therapies did not result in significantly higher proportions of parents reporting recovery (OR 11.12; 95% CI 0.46 to 267.52).One study measured infant sleeping time and found manipulative therapy resulted in statistically significant improvement (MD 1.17; 95% CI 0.22 to 2.12).The quality of the studies was variable. " 06/01/2021 - "Is foot reflexology effective in reducing colic symptoms in infants: A randomized placebo-controlled trial." 06/01/2021 - "Foot reflexology is a non-invasive and safe nursing intervention that is effective for reducing crying duration and symptoms in infants with colic." 12/01/2020 - "Reflexology treatment seems to be a safe and effective way to treat infants with colic when conducted by a health care professional with reflexology training and experience." 06/01/2021 - "The aim of this study was to examine the efficacy of foot reflexology for reducing symptoms of infantile colic. "