Infection with a fungus of the genus COCCIDIOIDES, endemic to the SOUTHWESTERN UNITED STATES. It is sometimes called valley fever but should not be confused with RIFT VALLEY FEVER. Infection is caused by inhalation of airborne, fungal particles known as arthroconidia, a form of FUNGAL SPORES. A primary form is an acute, benign, self-limited respiratory infection. A secondary form is a virulent, severe, chronic, progressive granulomatous disease with systemic involvement. It can be detected by use of COCCIDIOIDIN.
Also Known As:
Coccidioides immitis Infection; San Joaquin Valley Fever; Valley Fever; Coccidioides immitis Infections; Coccidioidomycoses; Infection, Coccidioides immitis; Infections, Coccidioides immitis; Valley Fevers
Networked: 527 relevant articles (53 outcomes, 47 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Histoplasmosis
2. Blastomycosis
3. Aspergillosis
4. Infection
5. Cryptococcosis


1. Blair, Janis E: 19 articles (03/2015 - 11/2004)
2. Ampel, Neil M: 18 articles (09/2015 - 09/2002)
3. Pappagianis, Demosthenes: 14 articles (08/2015 - 09/2002)
4. Blair, J E: 11 articles (06/2015 - 11/2001)
5. Galgiani, John N: 11 articles (06/2014 - 03/2006)
6. Wheat, L Joseph: 8 articles (10/2015 - 03/2007)
7. Fierer, Joshua: 8 articles (03/2014 - 05/2006)
8. Johnson, Suzanne M: 6 articles (08/2015 - 09/2002)
9. Thompson, George R: 6 articles (01/2015 - 09/2011)
10. Vikram, Holenarasipur R: 6 articles (10/2014 - 12/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Coccidioidomycosis:
1. Fluconazole (Zonal)FDA LinkGeneric
2. Itraconazole (Sporanox)FDA LinkGeneric
3. Amphotericin B (Amphotericin)FDA LinkGeneric
4. AntigensIBA
5. Ketoconazole (Nizoral)FDA LinkGeneric
6. Antifungal AgentsIBA
08/01/2011 - "Although recent studies suggest that the incidence of symptomatic coccidioidomycosis during pregnancy is decreasing and that outcome has improved, management is complicated by the observations that azole antifungal agents can be teratogenic when given to some women, particularly at high doses, early in pregnancy. "
09/01/2007 - "A number of studies addressing the efficacy of various antifungal agents have been performed, and the results of these studies as they pertain to skeletal coccidioidomycosis are summarized herein. "
05/01/2006 - "For the Finland lecture, I will briefly discuss the development of the Mycoses Study Group, provide an overview of the currently available antifungal agents, and describe advances and lessons related to the treatment and management of cryptococcal meningitis (the most common form of fungal meningitis), 3 important endemic mycoses (namely, blastomycosis, histoplasmosis, and coccidioidomycosis), candidemia and invasive candidiasis (the most common forms of nosocomial fungal disease), and invasive aspergillosis (the most common form of invasive mould disease). "
12/01/2004 - "The treatment of choice for cutaneous coccidioidomycosis is currently oral azole antifungal agents, such as itraconazole 400 mg daily, continued for 6 months after clinical response. "
12/01/2004 - "We present 2 cases of septic shock associated with coccidioidomycosis that were successfully treated with drotrecogin alfa (activated) in combination with antifungal agents. "
7. CoccidioidinIBA
8. nikkomycinIBA
9. deoxycholate drug combination amphotericin BIBA
10. Adrenal Cortex Hormones (Corticosteroids)IBA

Therapies and Procedures

1. Salvage Therapy
2. Transplantation (Transplant Recipients)
3. Transplants (Transplant)
4. Euthanasia (Mercy Killing)
5. Organ Transplantation