Cocaine (Cocaine HCl)

An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Also Known As:
Cocaine HCl; Cocaine Hydrochloride; HCl, Cocaine; Hydrochloride, Cocaine; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-
Networked: 6739 relevant articles (215 outcomes, 887 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Gelernter, Joel: 31 articles (05/2014 - 04/2002)
2. Kranzler, Henry R: 29 articles (01/2015 - 06/2004)
3. Kosten, Thomas R: 27 articles (08/2013 - 01/2002)
4. Sinha, Rajita: 24 articles (01/2016 - 03/2005)
5. Brady, Kathleen T: 23 articles (12/2014 - 01/2002)
6. Volkow, Nora D: 18 articles (12/2014 - 04/2003)
7. Kampman, Kyle M: 18 articles (01/2014 - 01/2002)
8. Moeller, F Gerard: 17 articles (06/2015 - 09/2002)
9. Poling, James: 17 articles (01/2013 - 01/2003)
10. Potenza, Marc N: 15 articles (01/2016 - 10/2004)

Related Diseases

1. Cocaine-Related Disorders (Cocaine Addiction)
10/01/1997 - "Rates of complete abstinence during the 6-month study period were higher in STND than RP, whereas RP was more effective in limiting the extent of cocaine use in those who used during Months 1-3. Matching analyses indicated patients who failed to achieve remission from cocaine dependence during IOP and those with a commitment to absolute abstinence did better in RP than in STND, whereas patients with other abstinence goals did better in STND than RP. "
08/01/2014 - "Thus, disruption of cocaine reward memories by interference with reconsolidation may be therapeutically beneficial in the treatment of cocaine addiction. "
06/01/2005 - "Self reported cocaine use, cocaine craving, and global impression scores showed moderate improvement in both groups, with a significantly greater reduction in cocaine craving (p < 0.05) and self-rated severity of cocaine dependence (p < 0.05) in the placebo group. "
10/01/2004 - "Expanding research on reward-related brain circuitry, which is acutely activated and chronically dysregulated by cocaine, has helped reveal the neurobiological features of cocaine dependence and is guiding pharmacologic strategies that have significant potential to improve clinical outcome. "
08/01/2003 - "While the improvements were not significant between groups, within-group analysis revealed that the treatment group reduced self-reported cocaine use (P = 0.02), reduced criminal activity (P = 0.04), reduced cravings (P < 0.01) and reduced severity of cocaine dependence (P < 0.01) with no within-group improvements found in the placebo group. "
2. Substance-Related Disorders (Drug Abuse)
3. Seizures (Seizure)
4. Lacerations
5. Chest Pain (Chest Pains)

Related Drugs and Biologics

1. Epinephrine (Adrenaline)
2. Nicotine
3. Tetracaine (Amethocaine)
4. Methadone (Dolophine)
5. Heroin (Diamorphine)
6. Amphetamine (Amfetamine)
7. Ethanol (Ethyl Alcohol)
8. Diazepam (Valium)
9. Methamphetamine (Desoxyn)
10. N-Methylaspartate (NMDA)

Related Therapies and Procedures

1. Self Administration (Administration, Self)
2. Drug Therapy (Chemotherapy)
3. Anesthesia
4. Injections
5. Prenatal Care