CME-Carbodiimide (CMEC)

Also Known As:

CMEC; 4-(2-((Cyclohexylimidocarbonyl)amino)ethyl)-4-methylmorpholinium; CME Carbodiimide; Carbodiimide, CME; Morpholinium, 4-(2-((cyclohexylcarbonimidoyl)amino)ethyl)-4-methyl-, salt with 4-methylbenzenesulfonic acid (1:1)

Networked: 75 relevant articles (1 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Imines: 310
  - Carbodiimides: 117
    - CME-Carbodiimide: 75
      - 1-cyclohexyl-3-(2-(4-morpholinyl)ethyl)carbodiimide: 155
      - N-cyclohexyl-N'-2-morpholinoethyl-carbodiimide-methyl-4-toluolsulfonate

Experts

1.	O'Donnell, Martha E: 8 articles (01/2019 - 12/2005)
2.	Lam, Tina I: 4 articles (05/2014 - 10/2006)
3.	Foroutan, Shahin: 4 articles (08/2011 - 12/2005)
4.	Anderson, Steven E: 3 articles (01/2019 - 10/2006)
5.	Wang, Xia: 2 articles (08/2022 - 03/2016)
6.	Zhang, Yu: 2 articles (01/2022 - 01/2019)
7.	Jin, Chen: 2 articles (01/2020 - 01/2017)
8.	Jorgensen, Neal W: 2 articles (01/2020 - 01/2019)
9.	Li, Qing: 2 articles (01/2020 - 01/2017)
10.	McClelland, Robyn L: 2 articles (01/2020 - 01/2019)

Related Diseases

1.	Inflammation (Inflammations) 06/01/2021 - "CMEC's stress, metabolism, inflammation and other dysfunctions have a causal relationship with coronary microvascular disease, and are also the main features of coronary microvascular disease in the early stage. " 01/01/2018 - "In conclusion, the current study indicated that miR-495 improved CMEC injury and inflammation by suppressing the NLRP3 inflammasome signaling pathway." 08/01/2022 - "In in vitro studies, the expression of CCDC80tide reduces Ang II-induced cardiomyocyte hypertrophy, cardiac microvascular endothelial cell (CMEC) inflammation, and mitigated vascular smooth muscle cell (VSMC) proliferation and collagen formation. "
2.	Hypoxia (Hypoxemia) 01/01/2022 - "In this study, hypoxia/reoxygenation (H/R) treatment significantly impaired CMEC functions and induced their pyroptosis, accompanied by KDM3A downregulation. " 02/01/2006 - "Using a novel approach, this study demonstrated that CMEC produce more baseline NO than cardiomyocytes, and that hypoxia activates NOS to increase NO production in both cell types. " 01/01/2023 - "Next, a hypoxia-induced cardiac microvascular endothelial cell (CMEC) model was established to observe the effects of C-L on EndMT. " 03/01/2016 - "Here we investigated the potential role of autophagy in CMEC dysfunction under hypoxia. " 05/15/2014 - "We found that hypoxia, aglycemia, and AVP increase CMEC NHE activity through 5 h and that NHE1, but not NHE2, abundance is increased by 1- to 5-h exposures to these factors. "
3.	Atherosclerosis 01/01/2019 - "Approach and Results- We measured CMEC in 2 cohorts aged 45 to 84 years at baseline derived from the MESA (Multi-Ethnic Study of Atherosclerosis). " 11/01/2022 - "CMEC was measured in 1626 Multi-Ethnic Study of Atherosclerosis (MESA) participants in samples obtained between 2000 and 2002 as part of two nested case-control studies, one with cases of incident cardiovascular disease and the other with cases of carotid plaque progression by ultrasound. " 01/01/2020 - "CMEC was measured in 1458 Multi-Ethnic Study of Atherosclerosis participants between 2000 and 2002 as part of a case-control study matched for incident cardiovascular disease and progression of carotid plaque by ultrasound. "
4.	Neoplasms (Cancer) 01/01/2023 - "In conclusion, the versatile biomimetic CMEC-Dbait was characterized of low toxicity, excellent biocompatibility and satisfactory drug delivery efficiency, which is confirmed to be an ideal radiosensitizer for homologous cancer and merits further investigation in both pre-clinical and clinical studies." 03/01/2019 - "Central MEC (CMEC) is a rare tumor which affects women more than men and is more common in the mandible. " 07/01/1999 - "To further test the specificity of the mitogenic activity of Ea-4-peptide, three other cell lines were used: retroviral transformed human embryonic kidney cells (293GP), human mammary gland tumor cells (MCF-7) and caprine mammary epithelial cells (CMEC). " 01/01/2023 - "The result was validated in vivo using mouse xenograft models of EC, the results illustrated that radiotherapy plus CMEC-Dbait significantly suppressed tumor growth and prolonged survival of tumor bearing mice. " 09/01/2016 - "In due course, postoperative radiotherapy was applied (60 Gy) CMEC represents a rare tumor, characterized by local tissue destruction and ability to metastasize. "
5.	Cardiovascular Diseases (Cardiovascular Disease) 01/01/2019 - "Higher CMEC level was significantly associated with lower odds of cardiovascular disease (odds ratio, 0.82 per SD of CMEC [95% CI, 0.69-0.98; P=0.031] in the fully adjusted model) in cohort 1 but higher odds of carotid plaque progression (odds ratio, 1.24 per SD of CMEC [95% CI, 1.04-1.48; P=0.018] in the fully adjusted model) in cohort 2 but without dose-response effect. " 11/01/2022 - "CMEC was measured in 1626 Multi-Ethnic Study of Atherosclerosis (MESA) participants in samples obtained between 2000 and 2002 as part of two nested case-control studies, one with cases of incident cardiovascular disease and the other with cases of carotid plaque progression by ultrasound. " 01/01/2020 - "CMEC was measured in 1458 Multi-Ethnic Study of Atherosclerosis participants between 2000 and 2002 as part of a case-control study matched for incident cardiovascular disease and progression of carotid plaque by ultrasound. " 01/01/2019 - "Objective- To assess the role of HDL (high-density lipoprotein)-mediated cholesterol mass efflux capacity (CMEC) in incident cardiovascular disease and carotid plaque progression. "

Related Drugs and Biologics

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2.	Glucose (Dextrose)
3.	Long Noncoding RNA
4.	Insulin Receptor Substrate Proteins
5.	HMGB1 Protein (HMG1)
6.	Zinc
7.	Lipids
8.	Indicators and Reagents (Reagents)
9.	Hypoglycemic Agents (Hypoglycemics)
10.	Collagen

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Conservative Treatment
4.	Mandibular Osteotomy
5.	Catheters