|1.||Migraine Disorders (Migraine)
|4.||Cluster Headache (Cluster Headaches)
|5.||Trigeminal Neuralgia (Tic Douloureux)
|1.||Goadsby, Peter J: 21 articles (03/2015 - 05/2002)|
|2.||Goadsby, P J: 14 articles (11/2010 - 05/2000)|
|3.||Leone, Massimo: 12 articles (06/2013 - 05/2003)|
|4.||May, Arne: 11 articles (10/2013 - 06/2003)|
|5.||Bussone, Gennaro: 11 articles (01/2013 - 01/2004)|
|6.||Leone, M: 10 articles (09/2007 - 03/2000)|
|7.||Bussone, G: 10 articles (09/2007 - 03/2000)|
|8.||May, A: 9 articles (06/2011 - 10/2001)|
|9.||Rozen, Todd D: 8 articles (04/2015 - 04/2002)|
|10.||Straube, A: 7 articles (10/2015 - 12/2000)|
|1.||Sumatriptan (Imigran)FDA LinkGeneric
03/01/1998 - "Sumatriptan, an agonist of 5-HT1-like receptors, has proven effective in the treatment of cluster headache attacks. "
11/01/1995 - "Preemptive oral treatment with sumatriptan 100 mg tid for 7 days did not produce a significant reduction in the number or severity of cluster headache attacks occurring during an established cluster headache period. "
01/01/2002 - "Four patients continued to treat all cluster headache attacks with the intranasal sumatriptan formula, two patients had switched to subcutaneous sumatriptan and one patient was in remission since the end of the study. "
09/01/2005 - "We conclude that sumatriptan in doses less than 6 mg can be effective in the acute treatment of cluster headache attacks. "
09/01/2005 - "Subcutaneous (SQ) sumatriptan 6 mg is effective in the treatment of acute cluster headache attacks. "
06/01/1997 - "A controlled study was done with the aim of assessing the efficacy of hyperbaric oxygen (HBO2) in cluster headache and of studying the possible influence of this therapeutic approach on serotonergic pathways. "
04/01/2013 - "Demand valve oxygen appears to be an effective acute treatment for cluster headache. "
04/01/1996 - "Exposure to hyperbaric oxygen has been shown to be effective in cluster headache, but the mechanism of the action is still not clear. "
05/01/2003 - "This study of sleep changes in patients with cluster headache (CH) was conducted in view of the nocturnal predominance of this condition, the efficacy of oxygen and the fact that the attacks follow oxygen desaturation. "
10/01/2013 - "Cluster headache and oxygen: is it possible to predict which patients will be relieved? "
07/01/2012 - "In this study, we attempted to evaluate the response to lithium treatment and its tolerability in the prevention of episodic cluster headache (CH) and to identify clinical predictors of response. "
10/01/1997 - "Double-blind placebo-controlled trial of lithium in episodic cluster headache."
07/01/2012 - "Evaluation of lithium response in episodic cluster headache: a retrospective case series."
08/01/1999 - "Patients with cluster headache are often treated with lithium. "
01/01/1998 - "Lithium vs placebo in cluster headache."
01/01/2014 - "Triptans are only effective in terminating cluster headache (CH) attacks in 70-80% of patients. "
12/01/2013 - "Triptans are effective for immediate relief of episodic cluster headache (CH) but do not reduce the frequency of attacks. "
01/01/2013 - "Randomised, double-blind, placebo-controlled studies of triptans for acute treatment of cluster headache episodes. "
01/01/2010 - "Randomised, double-blind, placebo-controlled studies of triptans for acute treatment of cluster headache episodes. "
01/01/2013 - "Triptans for acute cluster headache."
|5.||Ergotamine (Ergotamine Tartrate)FDA LinkGeneric
05/01/2002 - "He was probably one of the first to describe the cluster phenomenon itself and the effectiveness of ergotamine in treating acute attacks of cluster headache. "
01/01/2002 - "Oral ergotamine tartrate may be sufficient for patients with night attacks and/or short, rather mild to moderately severe cluster headache periods. "
03/01/1983 - "Only inhalation of ergotamine resulted in early (at 5 min) peak concentrations of ergotamine in plasma and is therefore most likely to relieve the short-lived attacks of cluster headache. "
03/01/1983 - "Bioavailability and rate of absorption of ergotamine were studied in eight cluster headache patients outside attacks. "
03/01/1983 - "Optimal routes of administration of ergotamine tartrate in cluster headache patients. "
09/01/2002 - "It is perhaps the phase-shifting properties of melatonin that mediate its effect in patients with episodic cluster headache, and it may be necessary to treat from the beginning of the cluster bout to reset the circadian pacemaker, thus producing a more positive outcome."
06/01/2005 - "A double-blind, placebo-controlled trial shows melatonin is effective in cluster headache prevention, other studies also show benefit in other disorders. "
09/01/2002 - "A previous study of melatonin for primary prophylaxis of cluster headache demonstrated a 50% response rate. "
11/01/1996 - "During a cluster period, we administered melatonin to 20 cluster headache patients (2 primary chronic, 18 episodic) in a double-blind placebo-controlled study of oral melatonin 10 mg (n = 10) or placebo (n = 10) for 14 days taken in a single evening dose. "
06/01/1994 - "The melatonin concentrations in nocturnal urine were permanently low in cluster headache and there was no consistent change of the melatonin concentration in relation to cluster periods occurring during the study. "
|7.||zolmitriptan (Zomig)FDA Link
01/01/2013 - "Although nasal spry of zolmitriptan is not available in Japan, it is also reported to be effective for the acute phase of cluster headache. "
07/01/2002 - "Oral zolmitriptan is also effective in the acute treatment of cluster headache. "
05/09/2000 - "Oral zolmitriptan is effective in the acute treatment of cluster headache."
10/01/2009 - "To conduct an individual subject meta-analysis of available controlled studies of zolmitriptan nasal spray in the acute treatment of cluster headache. "
10/01/2009 - "Zolmitriptan nasal spray in the acute treatment of cluster headache: a meta-analysis of two studies."
|8.||topiramate (Topamax)FDA LinkGeneric
03/01/2010 - "This open-label study suggests that topiramate is effective in the treatment of cluster headache in Taiwanese patients."
03/01/2010 - "We performed an open-label clinical study to evaluate the efficacy of topiramate in the tolerable dosage to prevent cluster headache. "
11/01/2001 - "Topiramate demonstrated efficacy in a study of 15 patients, with a mean time to induction of cluster headache remission of 1.4 weeks (range, 1 day to 3 weeks). "
04/01/2006 - "[Remission of atypical and refractory cluster headache after topiramate administration]."
12/01/2003 - "Topiramate in cluster headache prophylaxis: an open trial."
|9.||Capsaicin (Zostrix)FDA Link
03/01/1994 - "In order to verify the reproducibility of therapeutic effect of capsaicin, we carried out a 2-year follow-up study on patients affected by cluster headache (17 by episodic form, 8 by chronic form) who responded positively to the first treatment with capsaicin. "
04/01/1994 - "Capsaicin was applied unilaterally to the nostril mucosa of 18 episodic cluster headache sufferers in remission. "
12/01/1994 - "Preliminary studies have shown that repeated nasal applications of capsaicin prevented the occurrence of cluster headache attacks. "
04/01/1994 - "Capsaicin-induced neurochemical changes in saliva and in plasma were compared to the changes observed during cluster headache attacks measured in a separate study. "
04/01/1993 - "A double-blind placebo-controlled trial of intranasal capsaicin for cluster headache."
|10.||Lithium Carbonate (Eskalith)FDA LinkGeneric
06/01/1983 - "Lithium carbonate in cluster headache: assessment of its short- and long-term therapeutic efficacy."
06/01/1980 - "Lithium carbonate in chronic cluster headache assessment of therapeutic efficacy and possible mechanisms of action."
01/01/1979 - "Therefore we selected five patients who at one time or another had presented with cluster headache and who had no relief from conventional treatment, and treated them with lithium carbonate. "
01/01/1980 - "Twenty-one patients with cluster headaches participated in an open trial to assess the effectiveness of lithium carbonate in the acute treatment and prevention of cluster headaches. "
01/01/2008 - "For chronic cluster headache, lithium carbonate is recommended after a few weeks if these other treatments have failed. "
|1.||Deep Brain Stimulation
01/01/2013 - "Deep brain stimulation (DBS) of the posterior hypothalamus (pHyp) has been reported as an effective treatment for primary, drug-refractory and chronic cluster headache (CCH). "
06/01/2012 - "Hypothalamic deep brain stimulation is effective in drug-resistant chronic cluster headache (drCCH) but not riskless. "
12/01/2011 - "Deep brain stimulation (DBS) of the posterior hypothalamus has been found to be effective in the treatment of refractory chronic cluster headache (CCH). "
11/01/2009 - "Deep-brain stimulation (DBS) of the posterior hypothalamus has been shown to be clinically effective for drug-resistant chronic cluster headache, but the underlying mechanism is still not understood. "
05/01/2008 - "Recently, deep brain stimulation of the posterior hypothalamus has been shown to be effective in the treatment of drug-resistant chronic cluster headache. "
10/01/2011 - "Suboccipital steroid injections can be used for preventive treatment of cluster headache but few data are available for the efficacy of this approach in clinical trials. "
10/01/2011 - "Suboccipital steroid injections for transitional treatment of patients with more than two cluster headache attacks per day: a randomised, double-blind, placebo-controlled trial."
06/01/2012 - "We retrospectively analysed the efficacy and safety of 121 GON injections in 60 patients with episodic or chronic cluster headache over a period of 4 years. "
06/01/2012 - "Efficacy and safety of 121 injections of the greater occipital nerve in episodic and chronic cluster headache."
10/01/2011 - "Suboccipital steroid injections for cluster headache."
09/01/1998 - "Subcutaneous injection of sumatriptan is an effective treatment for attacks of cluster headache with a short onset of action. "
01/01/2013 - "Subcutaneous injection and nasal spray of sumatriptan are known to be useful for the treatment of acute phase of cluster headache. "
01/01/2005 - "In all occasion, sumatriptan nasal spray showed meaningful relief in patients with cluster headache, although the efficacy were less than that of sumatriptan subcutaneous injection. "
01/01/1993 - "A subcutaneous injection of 6 mg sumatriptan rapidly and effectively stopped attacks of cluster headache. "
08/01/1991 - "The patients received, in random order, a subcutaneous injection of 6 mg of sumatriptan for one cluster-headache attack and placebo for another attack. "
|4.||Nerve Block (Nerve Blocks)
02/01/2014 - "Greater occipital nerve blocks in chronic cluster headache: a prospective open-label study."
09/01/2002 - "We treated 14 cluster headache patients with greater occipital nerve block as transitional therapy (treatment initiated at the same time as preventive therapy). "
04/01/2015 - "Occipital nerve block prior to occipital nerve stimulation for refractory chronic migraine and chronic cluster headache: myth or prediction?"
01/01/2013 - "In addition to these medications, some of refractory chronic cluster headache patients are reported to be respond to the occipital nerve block, deep brain stimulation, vagus nerve stimulation and occipital nerve stimulation. "
11/01/2009 - "Occipital nerve block is an effective treatment for cervicogenic headache, cluster headache, and occipital neuralgia. "