HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Clozapine (Clozaril)

A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Also Known As:
Clozaril; Leponex; 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
Networked: 4163 relevant articles (509 outcomes, 749 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Meltzer, Herbert Y: 65 articles (01/2016 - 03/2002)
2. Lieberman, Jeffrey A: 39 articles (01/2016 - 02/2002)
3. Remington, Gary: 33 articles (10/2015 - 01/2002)
4. Correll, Christoph U: 26 articles (10/2015 - 01/2007)
5. Kennedy, James L: 25 articles (01/2016 - 10/2002)
6. Kane, John M: 25 articles (10/2015 - 01/2002)
7. Green, Alan I: 21 articles (10/2015 - 04/2002)
8. Kelly, Deanna L: 20 articles (11/2015 - 03/2003)
9. Freudenreich, Oliver: 20 articles (01/2013 - 02/2004)
10. Henderson, David C: 19 articles (05/2015 - 01/2002)

Related Diseases

1. Schizophrenia (Dementia Praecox)
2. Agranulocytosis (Granulocytopenia)
3. Psychotic Disorders (Schizoaffective Disorder)
4. Bipolar Disorder (Mania)
5. Movement Disorders (Movement Disorder)

Related Drugs and Biologics

1. Antipsychotic Agents (Antipsychotics)
2. olanzapine (Zyprexa)
3. Risperidone (Risperdal Consta)
4. quetiapine (Seroquel)
5. Haloperidol (Haldol)
6. ziprasidone (Geodon)
7. aripiprazole (Abilify)
8. Levodopa (L Dopa)
9. Lithium
10. sultopride (amisulpride)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Polypharmacy
3. Aftercare (After-Treatment)
4. Injections
5. Withholding Treatment