Cloxacillin (Tegopen)

A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.

Also Known As:

Tegopen; Cloxacillin Sodium; Syntarpen; Cloxacillin, Sodium; Sodium, Cloxacillin; Chloroxacillin; Sodium Cloxacillin; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((3-(2-chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-

Networked: 419 relevant articles (50 outcomes, 48 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Almela, Manel: 4 articles (12/2021 - 06/2014)
2.	Falces, Carlos: 4 articles (12/2021 - 06/2014)
3.	Gasch, Oriol: 4 articles (12/2021 - 01/2018)
4.	Marco, Francesc: 4 articles (12/2021 - 06/2014)
5.	Moreno, Asuncion: 4 articles (12/2021 - 08/2003)
6.	Soy, Dolors: 4 articles (12/2021 - 06/2014)
7.	Castañeda, Ximena: 3 articles (12/2021 - 06/2014)
8.	Fuster, David: 3 articles (12/2021 - 01/2018)
9.	Llopis, Jaume: 3 articles (12/2021 - 01/2018)
10.	Miró, Jose M: 3 articles (12/2021 - 01/2018)

Related Diseases

1.	Infections 12/01/1981 - "No successes were recorded with other drugs, notably cloxacillin, and no infections due to Staphylococcus aureus were eradicated. " 12/15/1996 - "Of the 37 patients who completed 2-week treatment with cloxacillin, 34 (92%) were cured, and 3 (8%) needed prolonged treatment to cure the infection. " 10/01/2022 - "Conclusion Clindamycin or cloxacillin can be used as a first-line option for neck infection in children. " 11/17/2020 - "A Population Pharmacokinetic Analysis of Continuous Infusion of Cloxacillin during Staphylococcus aureus Bone and Joint Infections." 12/01/2017 - "Systematic overdosing of oxa- and cloxacillin in severe infections treated in ICU: risk factors and side effects."
2.	Endocarditis 07/01/1992 - "At all dosages, cloxacillin was significantly less effective in preventing endocarditis with the tolerant strain than with the nontolerant variant. " 01/01/2023 - "Development and validation of a dosing nomogram for continuous infusion cloxacillin in infective endocarditis." 06/01/2014 - "aureus infective endocarditis (IE) treated with cloxacillin. " 03/01/2009 - "We describe a failure of cloxacillin for a patient with endocarditis due to BORSA. " 03/01/1994 - "During treatment of endocarditis caused by a tolerant strain, the reduction of bacterial numbers in the infected vegetations decreased significantly with increasing doses of cloxacillin. "
3.	Mastitis 09/01/2009 - "In this study, the effects of prepartum treatment of nonlactating heifers with a 600-mg cloxacillin dry cow treatment on the prevalence of culture-positive milk samples at calving and 10 to 14 d in milk (DIM), the incidence of clinical mastitis, somatic cell count (SCC), and milk production during first lactation were quantified. " 12/01/1976 - "The paper describes the study of the extent to which the use of the Orbenin -- dry cow preparation (with cloxacillin as the active substance) was successful in the treatment of mastitis caused by Streptococcus agalactiae. " 09/01/2009 - "Treatment with cloxacillin 8 to 10 wk before calving resulted in a lower prevalence of culture-positive milk samples at calving and lower quarter milk SCC in early lactation [30,000 +/- 4,600 (standard deviation) cells/mL in treated heifers versus 40,000 +/- 4,600 cells/mL in control heifers], and was associated with lower average test-day SCC (55,000 +/- 1,400 cells/mL in treated heifers versus 71,000 +/- 1,500 cells/mL in control heifers) and lower incidence of clinical mastitis throughout lactation. " 05/24/2008 - "The quarters treated with the internal sealant and cloxacillin were significantly more likely to be bacteriologically negative in the immediate period after calving and were significantly less likely to suffer clinical mastitis during the first 100 days after calving than the quarters treated with cloxacillin alone. " 07/01/2006 - "Mean cloxacillin concentration in untreated quarters was below minimum inhibitory concentrations for targeted mastitis pathogens. "
4.	Bovine Mastitis 05/01/1983 - "Twenty-four isolates of Staphylococcus aureus from naturally occurring cases of bovine mastitis were examined in vitro for resistance to cloxacillin. " 04/01/1996 - "Florfenicol did not offer any advantage over cloxacillin in efficacy against bovine mastitis. " 04/01/1996 - "Florfenicol and cloxacillin did not differ significantly in efficacy versus clinical (n = 85) or subclinical (n = 71) bovine mastitis, or for any etiologic agent (X2). " 08/01/1972 - "Methicillin (cloxacillin)-resistant Staphylococcus aureus strains isolated from bovine mastitis cases." 05/01/1983 - "Penicillin (cloxacillin)-tolerant Staphylococcus aureus from bovine mastitis: identification and lack of correlation between tolerance in vitro and response to therapy in vivo."
5.	Staphylococcal Infections 09/26/1964 - "CLOXACILLIN IN THE THERAPY OF STAPHYLOCOCCAL INFECTION." 06/12/2021 - "The inclusion criteria were adult patients hospitalized in a medical department at the Le Mans Hospital between 1 July 2012 and 1 July 2019 with a diagnosis of methicillin-sensitive Staphylococcus aureus infection treated with cloxacillin. " 12/29/2018 - "This case report signifies the potential fatal adverse effect of cloxacillin in methicillin-sensitive Staphylococcus aureus infections. " 12/01/2010 - "Traditionally, methicillin resistant Staphylococcus aureus (MRSA) is considered as a nosocomial pathogen, but an increasing prevalence of community acquired MRSA is being reported worldwide including India, which implies a strategic change in the antibiotic of choice for treatment of community acquired Staphylococcal infections, which till now is cloxacillin. " 12/01/2006 - "Coagulase-negative staphylococcal infections in a neonatal intensive care unit: In vivo response to cloxacillin."

Related Drugs and Biologics

1.	Vancomycin
2.	Gentamicins (Gentamicin)
3.	Methicillin (Metin)
4.	Ampicillin (Omnipen)
5.	Anti-Bacterial Agents (Antibiotics)
6.	Penicillins (Penicillin)
7.	Rifampin (Rifampicin)
8.	Daptomycin
9.	Teicoplanin
10.	Ciprofloxacin (Cipro)

Related Therapies and Procedures

1.	Therapeutics
2.	Craniotomy
3.	Culture Diffusion Chambers
4.	Catheters
5.	Antibiotic Prophylaxis