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Microbial Collagenase (Clostridiopeptidase A)

A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.
Also Known As:
Clostridiopeptidase A; Clostridium histolyticum Collagenase; Collagenase-Like Peptidase; Collalysine; Nucleolysin; Collagenase Like Peptidase; Collagenase, Clostridium histolyticum; Peptidase, Collagenase-Like; Collagenase, Microbial
Networked: 100 relevant articles (9 outcomes, 35 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Tursi, James P: 8 articles (11/2015 - 01/2013)
2. Kaufman, Gregory J: 7 articles (11/2015 - 01/2013)
3. Smith, Ted: 7 articles (08/2015 - 06/2012)
4. Hellstrom, Wayne J G: 5 articles (12/2015 - 07/2013)
5. Coleman, Stephen: 5 articles (10/2015 - 12/2010)
6. Kaplan, F Thomas D: 5 articles (09/2015 - 09/2009)
7. Hurst, Lawrence C: 4 articles (10/2015 - 09/2009)
8. Matsushita, Osamu: 4 articles (01/2015 - 09/2008)
9. Levine, Laurence A: 4 articles (01/2015 - 06/2012)
10. Gerber, Robert A: 4 articles (04/2014 - 11/2011)

Related Diseases

1. Dupuytren Contracture (Dupuytrens Contracture)
2. Penile Induration (Peyronie's Disease)
3. Contracture
4. Congenital Abnormalities (Deformity)
5. Leiomyoma (Uterine Fibroids)

Related Drugs and Biologics

1. Collagenases (Collagenase)
2. Collagen
3. Interferons
4. propylene diquat (PDQ(+))
5. prolyl oligopeptidase (prolyl endopeptidase)
6. Matrix Metalloproteinases
7. Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)
8. Peptide Hydrolases (Proteases)
9. Ions
10. Immunoglobulin G (IgG)

Related Therapies and Procedures

1. Injections
2. Intralesional Injections
3. Debridement
4. Phonophoresis
5. Transplants (Transplant)