HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Clorgyline (Clorgiline)

An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.
Also Known As:
Clorgiline; Chlorgyline; Clorgilin; 2-Propyn-1-amine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl-
Networked: 49 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Zhao, Hongjuan: 2 articles (11/2010 - 01/2009)
2. Peehl, Donna M: 2 articles (11/2010 - 01/2009)
3. Flamand, Vincent: 2 articles (11/2010 - 01/2009)
4. Noveanu, Lavinia: 1 article (09/2015)
5. Dănilă, Maria D: 1 article (09/2015)
6. Mirica, Silvia N: 1 article (09/2015)
7. Privistirescu, Andreea I: 1 article (09/2015)
8. Sturza, Adrian: 1 article (09/2015)
9. Muntean, Danina M: 1 article (09/2015)
10. Duicu, Oana M: 1 article (09/2015)

Related Diseases

1. Body Weight (Weight, Body)
2. Fever (Fevers)
3. Hyperalgesia
4. Body Temperature Changes
5. Seizures (Seizure)
01/01/1986 - "At the same time chlorgyline had an overall protective effect, increasing two-fold the period prior to the development of oxygen convulsions. "
10/01/1987 - "The possibility is shown to prevent oxygen seizures not only with irreversible MAO-A inhibitors (clorgyline), but also with reversible ones (moclobemide)."
05/01/1986 - "A preliminary injection of clorgyline (a monoamine oxidase type A inhibitor) before hyperoxic exposure leads to a significant removal of oxygen seizures and prevents changes in the cerebral spermidine and histamine content observed in the unprotected animals. "
10/01/1980 - "All six drugs also potentiated tryptamine in producing body tremors and clonic seizures, the rank order of potency being tranylcypromine (0.081)>clorgyline (0.14) greater than or equal to pheniprazine (0.15)>pargyline (1.97)>deprenyl (15.5)>nialamide (18.7). "
09/01/1985 - "Repeated administration of drugs that increase tryptaminergic neurotransmission antagonized the increase in latency to onset and the duration of postdecapitation convulsions (PDCs) induced by an acute 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) injection; Zimelidine (2 X 5 mg kg-1), fluoxetine (2 X 5 mg kg-1), amiflamine (2 X 2.5 mg kg-1) and alpha-ethyltryptamine (2 X 2.5 mg kg-1) administered orally over 10 days caused a substantial blockade of the increase in latency to onset and duration of PDCs following 5-MeODMT, whereas alaproclate (2 X 5 mg kg-1), clorgyline (1 X 1 mg kg-1) and pargyline (2 X 2.5 mg kg-1) caused a lesser blockade. "

Related Drugs and Biologics

1. Monoamine Oxidase (MAO)
2. Selegiline (E250)
3. N-Methyl-3,4-methylenedioxyamphetamine (MDMA)
4. Glycine (Aminoacetic Acid)
5. milacemide
6. Pargyline (Pargyline Hydrochloride)
7. Norepinephrine (Noradrenaline)
8. Tranylcypromine (Parnate)
9. Serotonin (5 Hydroxytryptamine)
10. Oxygen

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Induced Hypothermia
3. Induced Hyperthermia (Thermotherapy)