Citrate (si)-Synthase (Synthase, Citrate)

Enzyme that catalyzes the first step of the tricarboxylic acid cycle (CITRIC ACID CYCLE). It catalyzes the reaction of oxaloacetate and acetyl CoA to form citrate and coenzyme A. This enzyme was formerly listed as EC
Also Known As:
Synthase, Citrate; Citrate Synthase; Citrate oxaloacetate-lyase ((pro-3S)-CH2COO(-)--acetyl-CoA)
Networked: 307 relevant articles (10 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Inokuma, Hisashi: 7 articles (01/2013 - 01/2002)
2. Streck, Emilio L: 6 articles (08/2013 - 05/2007)
3. Scaini, Giselli: 5 articles (10/2013 - 05/2010)
4. Quevedo, João: 5 articles (12/2011 - 05/2007)
5. Herndon, David N: 3 articles (09/2015 - 08/2008)
6. Clarke, Kieran: 3 articles (11/2014 - 12/2008)
7. Tarnopolsky, Mark A: 3 articles (01/2014 - 04/2007)
8. Krieger, José E: 3 articles (11/2012 - 11/2006)
9. Gomes, Lara M: 3 articles (12/2011 - 05/2010)
10. Tremblay, Angelo: 3 articles (03/2008 - 03/2002)

Related Diseases

1. Anoxia (Hypoxia)
2. Body Weight (Weight, Body)
3. Ischemia
4. Fatigue
5. Atrophy
09/01/1981 - "Muscle weights of the CA-treated freely eating N controls were significantly less than that of N runners that received CA. In plantaris muscles of both N and C animals that received CA, total protein concentration and citrate synthase activity, a mitochondrial marker, remained constant, but their amounts per muscle decreased in proportion to the atrophy. "
09/01/1986 - "Protein deprived rats showed atrophy of type 2 fibres predominantly, reduced histochemical activity of succinic dehydrogenase (SDH) and reduced biochemical activity of citrate synthase. "
05/01/2005 - "Of 26 patients, results of analysis of 3 patients (1 Duchenne muscular dystrophy, 1 spinal muscular atrophy and 1 type II fibre atrophy) were excluded because the citrate synthase activities in their muscle homogenate were less than third percentile of the normal controls. "
03/01/1996 - "It was found that, in sedentary rats, hypoxia results in stunted growth, adrenal atrophy, a significant reduction of cross-sectional area of fast-twitch (type II) fibres, a reduced capillary-to-fibre ratio (C/F), and a reduced oxidative capacity (decreases in citrate synthase and 3-hydroxy-Acyl CoA dehydrogenase activities) of the plantaris muscle. "
01/01/2014 - "Concurrent exercise altered the expression of genes involved in mitochondrial biogenesis (PGC-1α, PRC, PPARγ), hypertrophy (PGC-1α4, REDD2, Rheb) and atrophy (MuRF-1, Runx1), increased electron transport chain complex protein content, citrate synthase and mitochondrial cytochrome c oxidase enzyme activity, muscle mass, maximum isometric strength and VO 2peak. "

Related Drugs and Biologics

1. L-Lactate Dehydrogenase (Lactate Dehydrogenase)
2. Oxygen
3. Superoxide Dismutase
4. Fatty Acid Synthetase Complex (Fatty Acid Synthase)
5. Oxidoreductases
6. Acyl-CoA Dehydrogenase (Medium-Chain Acyl-Coenzyme A Dehydrogenase)
7. Glycogen
8. coenzyme Q10 (CoQ10)
9. Acetyl-CoA Carboxylase
10. Adrenergic Receptors (Adrenergic Receptor)

Related Therapies and Procedures

1. Denervation
2. Knee Replacement Arthroplasty (Total Knee Replacement)
3. Pancreaticoduodenectomy
4. Heart Transplantation (Grafting, Heart)
5. Surgical Instruments (Clip)