|1.||Hirama, Masahiro: 20 articles (06/2015 - 12/2002)|
|2.||Lewis, Richard J: 10 articles (12/2013 - 06/2002)|
|3.||Inoue, Masayuki: 9 articles (02/2015 - 12/2002)|
|4.||Chinain, Mireille: 9 articles (06/2014 - 09/2005)|
|5.||Yamashita, Shuji: 8 articles (06/2015 - 07/2006)|
|6.||Laurent, Dominique: 8 articles (01/2013 - 01/2005)|
|7.||Ramsdell, John S: 7 articles (03/2013 - 09/2005)|
|8.||Botana, Luis M: 6 articles (09/2015 - 01/2006)|
|9.||Molgó, Jordi: 6 articles (10/2014 - 12/2002)|
|10.||Tsumuraya, Takeshi: 6 articles (03/2014 - 06/2003)|
10/01/2013 - "However, differences in the efficacy of these compounds to reverse ciguatoxin-induced cold allodynia did not correlate with their potency to inhibit ciguatoxin-induced responses in SH-SY5Y cells or at heterologously expressed Nav1.3, Nav1.6, Nav1.7, or Nav1.8, indicating cold allodynia might be more complex than simple activation of Nav channels. "
10/03/2012 - "Functional MRI studies revealed that ciguatoxin-induced cold allodynia enhanced the BOLD (Blood Oxygenation Level Dependent) signal, an effect that was blunted in TRPA1-deficient mice, confirming an important role for TRPA1 in the pathogenesis of cold allodynia."
10/01/2013 - "To establish their in vivo efficacy, we used a novel animal model of ciguatoxin-induced cold allodynia. "
10/01/2013 - "We show that intracutaneous administration of ciguatoxin in humans elicits a pronounced axon-reflex flare and replicates cold allodynia. "
10/01/2013 - "Analgesic treatment of ciguatoxin-induced cold allodynia."
|2.||Ciguatera Poisoning (Ciguatera)
10/01/2007 - "In order to assess the ciguatera risk in two islands of French Polynesia, Tubuai (Australes) and Nuku Hiva (Marquesas), a study was carried out on both Gambierdiscus populations as well as on various fish species using the receptor-binding assay (RBA) to detect and quantify ciguatoxins. "
12/15/2015 - "Ciguatera fish poisoning is a debilitating human neuro-intoxication caused by consumption of tropical marine organisms, contaminated with bioaccumulated ciguatoxins (CTXs). "
11/04/2015 - "To determine the ciguatoxic potential of brown-marbled grouper (Epinephelus fuscoguttatus) in relation to fish size and geographical origin, this review systematically analyzed: 1) reports of large ciguatera outbreaks and outbreaks with description of the fish size; 2) Pacific ciguatoxin (P-CTX) profiles and levels and mouse bioassay results in fish samples from ciguatera incidents; 3) P-CTX profiles and levels and risk of toxicity in relation to fish size and origin; 4) regulatory measures restricting fish trade and fish size preference of the consumers. "
11/01/2015 - "Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies)."
09/01/2015 - "Ciguatera fish poisoning (CFP) is a syndrome caused by the ingestion of fish contaminated with Ciguatoxins (CTXs). "
|3.||Body Weight (Weight, Body)
03/15/2013 - "In this study, we determined the toxicokinetic parameters of the Pacific ciguatoxin P-CTX-1 in rats after an intravenous (iv) dose of 0.13 ng P-CTX-1 per g of body weight. "
06/18/2011 - "In this study we evaluate the toxicokinetics of one of the most common ciguatoxins found in the Pacific, the P-CTX-1, in rat after an oral or intraperitoneal (ip) dose of 0.26 μg/kg body weight. "
01/01/1991 - "Light and electron microscopic studies of pathologic changes induced in mice by ciguatoxin poisoning."
12/01/2013 - "NPDS reported an average of 173 exposure calls for ciguatoxin and 200 exposure calls for scombroid fish poisoning annually (2005-2009). "
10/01/2011 - "Fatality and long-term sequelae are not uncommon with ciguatoxin poisoning and educating the general population is essential."
05/15/2009 - "Ladder-shaped polyether (LSP) compounds represented by brevetoxins and ciguatoxins were largely discovered in association with seafood poisoning. "
11/01/2007 - "Ciguatoxin may be a terrible coral fish toxin that can result in poisoning in people who eat fish containing ciguatoxin. "
10/01/2013 - "To identify compounds able to inhibit ciguatoxin-induced Nav responses, we developed a novel in vitro ciguatoxin assay using the human neuroblastoma cell line SH-SY5Y. "
08/30/2012 - "foertherianum leaves was prepared and studied for its effects against a Pacific ciguatoxin (P-CTX-1B) in the neuroblastoma cell assay and the receptor binding assay. "
01/01/2012 - "Towards the standardisation of the neuroblastoma (neuro-2a) cell-based assay for ciguatoxin-like toxicity detection in fish: application to fish caught in the Canary Islands."
01/01/2008 - "Detection of ciguatoxin in fish tissue using sandwich ELISA and neuroblastoma cell bioassay."
09/01/2005 - "Quantitation by the neuroblastoma cytotoxicity assay of Caribbean ciguatoxin (C-CTX-1) spiked into mice blood was made with good precision and recovery. "
|6.||Sodium Channels (Sodium Channel)