Cicatrix

1.	Cen, Ying: 4 articles (07/2008 - 08/2005)
2.	Mustoe, Thomas A: 4 articles (01/2008 - 09/2003)
3.	Alster, Tina S: 4 articles (03/2007 - 01/2002)
4.	Rieger, Ulrich M: 3 articles (10/2008 - 01/2007)
5.	Haug, Martin: 3 articles (10/2008 - 01/2007)
6.	Kalbermatten, Daniel F: 3 articles (10/2008 - 01/2007)
7.	Pierer, Gerhard: 3 articles (10/2008 - 01/2007)
8.	Vikhareva Osser, O: 3 articles (08/2008 - 08/2008)
9.	Valentin, L: 3 articles (08/2008 - 08/2008)
10.	Jokubkiene, L: 3 articles (08/2008 - 08/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cicatrix:

1.	CosmeticsIBA 08/01/1998 - "Without producing scars or permanent pigmentary changes a very good cosmetic result has been achieved and stigmatisation and psychic burden of this patient has been relieved." 01/01/1992 - "Its cosmetic appearance is superior to the preauricular coronal incision, and it is preferred especially by young people in whom the scar tends to widen with time." 11/01/2007 - "The main advantage of this procedure is that the small operative scar is concealed in the postauricular area resulting in improved cosmetic results." 12/01/2007 - "Photographic assessment of scars found visible cosmetic improvement in eleven patients" 08/01/2004 - "This article addresses options available for improved cosmetic outcome in horses with ocular scars or requiring enucleation" Order ALL the reference details at left...
2.	SiliconesIBA 05/01/2002 - "In most cases reconstruction with Skin-Expander and silicone implants meets the patients' desires: low-risk operation, fewer additional scars, and similar and improved breasts on both sides." 05/01/2006 - "RESULTS: All parameters in the Vancouver Scar Scale improved in both groups, although patients treated with the soft silicone dressing showed greater and more rapid improvements compared with the non-treated patients, while their assessments of the condition of the scar were more favourable" 06/01/1999 - "RESULTS: Both the silicone gel cushion and the silicone gel sheeting treatments were effective in decreasing scar volume, 53.0% and 36.3%, respectively" 10/01/1993 - "The silicone gel sheets resulted in moderate improvement in scar thickness, scar color and was noted to be effective to some degree in all tested" 09/01/2006 - "BACKGROUND: This study aimed to determine the efficacy of silicone gel (Cica-Care) on severe post-traumatic hypertophic scars among the Chinese population" Order ALL the reference details at left...
3.	CollagenIBA 07/01/2004 - "ECG showed a significant improvement in the quality of scar formation both in terms of maturity and orientation of the collagen fibers" 07/01/2002 - "However, a significant improvement in dermal collagen organization was noted on comparing Mederma-treated scars with untreated control scars (p < 0.05)" 10/01/2001 - "The stroma near corneal ulceration, scar tissue, calcified stroma and the retro-corneal collagen layer showed a significant reduction of birefringence (lower OPD values)" 10/01/2006 - "CONCLUSION: The results of this study suggest that treatment of atrophic scars using the CROSS method is more effective than simple application of TCA in activating fibroblasts in the dermis and increasing the amount of collagen." 04/01/1995 - "An experimental study on the prevention of postlaminectomy scar formation: efficacy of interpositional collagen-sponge]" Order ALL the reference details at left...
4.	Mitomycin (Mitomycin-C)FDA LinkGeneric 04/01/2007 - "PURPOSE: Mitomycin C (MMC) acts as a potent fibroblastic inhibitor, and topical application of MMC is effective in preventing scar formation" 03/01/2005 - "Use of topical mitomycin C in the ear may be beneficial in reducing scar and granulation tissue formation" 12/01/2004 - "After the recognition that topical application of Mitomycin-C (MMC) inhibits fibroblast proliferation and is effective in preventing scar formation, many studies have been carried out on this subject outside the scope of urology" 07/01/2004 - "Scar formation and restenosis is the main cause of failure, and this study assesses the efficacy of two adjuvant treatments: endoscopic steroid injection and topical mitomycin C application" 05/01/2006 - "Mitomycin C (MMC) inhibits fibroblast proliferation and is effective in reducing scar in animal experiments" Order ALL the reference details at left...
5.	Messenger RNA (mRNA)IBA 07/01/2008 - "Time-course changes of trkB mRNA expression demonstrated a robust increase in an area projecting from the rostral tip of the SN to the glial scar, which coincided with evidence of nigral dopaminergic sprouting" 04/01/2008 - "Differences among SCARs in mRNA levels and the biochemical efficiency of ARP2/3 activation may explain the functional contributions of individual genes." 01/01/2008 - "However, the mRNA expression of components of the extracellular matrix was attenuated in the infarct scar 12 weeks after MI and cell injection" 04/15/2007 - "Both MMP13 mRNA and protein colocalized to large phagocytes within and directly apposed to hepatic scars" 05/01/2006 - "Immunostaining with alphaSMA revealed that a substantial proportion of the ColXIII mRNA-expressing cells in the stromal scar tissues was myofibroblasts and that these areas lack CD34 immunoreactivity" Order ALL the reference details at left...
6.	ErbiumIBA 03/01/2008 - "BACKGROUND: A novel 1,550-nm erbium-doped laser (Fraxel, Reliant Technologies Inc.) has been shown to be effective in the treatment of photodamaged skin and scars with minimal postoperative recovery; however, studies evaluating its side effects and complication rates have been limited" 03/01/2007 - "A novel treatment using a 1,550-nm erbium-doped fiber laser to induce fractional photothermolysis of treated skin has been used to resurface photodamaged skin but has not been studied previously in patients with atrophic scars to determine its effectiveness for this condition" 10/01/2001 - "However, recent studies have shown the efficacy of the erbium laser in removing delicate and moderate scars" 03/01/2007 - "CONCLUSIONS: Atrophic scars can be effectively and safely reduced with 1,550-nm erbium-doped fiber laser treatment." 03/01/2007 - "PURPOSE: To determine the effectiveness and safety of 1,550-nm erbium-doped fiber laser treatment on atrophic scars" Order ALL the reference details at left...
7.	Tuberculin (PPD)IBA 09/01/1999 - "Children in group I with the BCG scar were noted to have significantly greater PPD induration size than in group II (14.14 +/- 11.23 vs 5.05 +/- 6.24 mm; P = 0.000)" 03/15/2008 - "This study has been designed to evaluate the immunogenicity of neonatal BCG-vaccination in children at the age of 7 to 8 years, by skin test using Purified Protein Derivative (PPD), as BCG vaccination at birth is a part of routine program of immunization in our country, Iran; we decided to study its efficacy and also tried to determine if there is any correlation between PPD-test results and BCG scar size" 06/01/2007 - "AIM: The aim of this study is to interpret purified protein derivative (PPD) induration sizes with respect to the number of Bacillus Calmette-Guérin (BCG) scars" 11/01/2006 - "Several studies have shown better survival for children reacting to their BCG vaccination with a BCG scar or tuberculin skin test reaction (TST)" 09/01/2000 - "Of the 115 infants enrolled to this study, 15 (13%) had no BCG scar and 50 (43.5%) had no tuberculin reaction" Order ALL the reference details at left...
8.	Retinaldehyde (Retinal)IBA 04/01/1987 - "Gross, microscopic, and ultrastructural studies of these cases showed varying degrees of retinal scarring and active CMV lesions at the margins of the scars" 08/15/1985 - "Detailed ultrastructural study of a peripapillary scar 30 months after the injection showed the presence of subretinal neovascularization located between Bruch's membrane and degenerated retinal inner segments" 04/01/2008 - "CONCLUSIONS: The MRL mouse retina shows elevated MMP expression and decreased levels of scar-related inhibitory molecules, which leads to a retinal environment that is more permissive for neural regeneration and cell integration after in vitro retinal explantation." 02/01/2007 - "PURPOSE: To measure the prevalence of toxoplasmic retinal scars in a young universitary population" 01/01/2007 - "Subretinal scar thickness was measured as Outer High Reflectivity Band Thickness (OHRBT) and retinal thickness as neuroretinal foveal thickness (NFT) on OCT3" Order ALL the reference details at left...
9.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/1996 - "The systemic administration of corticosteroids improved his skin lesions, leaving scars and milia" 09/01/2008 - "This suggests that the clinical use of corticosteroids may prevent scar formation following febrile UTI." 01/01/2003 - "The adjunctive use of intralesional corticosteroids did not significantly enhance clinical outcome except in those scars that were most symptomatic." 11/01/1998 - "Fibrotic scar formation in central serous chorioretinopathy developed during systemic treatment with corticosteroids." 05/01/1996 - "In another case, the scar recurred eight months after discontinuation of topical corticosteroids" Order ALL the reference details at left...
10.	decorinIBA 10/01/2008 - "In addition to suppressing inhibitory scar formation, our present data shows that decorin can directly boost the ability of neurons to extend axons within CSPG or myelin rich environments." 12/01/2006 - "Primed fibroblasts and exogenous decorin: potential treatments for subacute vocal fold scar." 01/01/2005 - "We hypothesized that scar formation could be prevented by controlling decorin expression in tendinocytes" 04/01/2004 - "The increase in decorin level coincided with the time of scar tissue stabilization, which implied that the delayed appearance was correlated with the formation of HS." 04/01/2004 - "CONCLUSION: The decrease of decorin in hyperplastic scar was resulted primarily from reduced synthesis" Order ALL the reference details at left...

Therapies and Procedures

1.	Lasers (Laser) 04/01/2004 - "Resurfacing with the dual-mode laser shows good to excellent results for ice-pick, shallow, and rolling scars and produced good results on deep boxcar scars" 05/01/1991 - "Postoperative complications were excessive subepiglottic swelling after laser excision (n = 1 horse), which resolved completely in response to anti-inflammatory treatment, and subepiglottic cicatrix formation after snare excision (n = 1 horse), which required surgical excision of the cicatrix." 04/01/2001 - "CONCLUSIONS: This study shows that surgical removal of post-laser CNV is technically feasible despite the previous laser scars and may have beneficial outcome" 09/01/1991 - "Circumferential laser thermoexclusion guided visually in the border zone of the infarct scar would seem to be a simple, safe, rapid and therefore attractive, surgical antiarrhythmic technique, the efficacy of which should be evaluated by programmed ventricular stimulation" 12/01/1999 - "RESULTS: The scars improved 80-89% in 65 patients, 70-79% in 56 patients, more than 90% in 32 patients, 60-69% in 2 patients, and less than 60% in 3 patients after laser treatment" Order ALL the reference details at left...
2.	Transplants (Transplant) 03/01/1995 - "Non-surgical and surgical procedures have been developed to correct this situation, the Abbe-Wharton-McIndoe operation is one with the best results, but it has the disadvantage that the scar produced in the place where the skin graft is taken has an awful appearance" 06/01/2001 - "The preliminary results with this protocol in a group of 12 children have shown better quality scars, more harmonious maxillary arches, an excellent occlusion of the deciduous dentition, and preservation of the positive results obtained with the periosteal tibial graft." 01/01/1992 - "The good results of primary wound healing, the absence of horizontal scars and the possibility of mobilisation of epithelium from the cleft region to cover the transplant with mucosa from the alveolar process are the advantages of this procedure." 06/01/1998 - "CONCLUSION: The prelesioned peripheral nerve graft is more effective than the untreated graft in suppressing astrocytic scar formation and in supporting the outgrowth of regenerating axons in the dorsal funiculus of rat spinal cord." 06/01/1987 - "In conclusion, pedicle fat grafts were more effective in preventing dural scar formation and protecting the cord than free fat grafts." Order ALL the reference details at left...
3.	Sutures (Suture) 01/01/1989 - "A study of skin suture following elliptical excision of tattoos from the upper limb shows that when the dermis is supported by a subcuticular non-absorbable suture for 6 months there is (a) a highly significant and numerically considerable (37.5%) reduction of scar stretching over that following conventional interrupted skin suture and (b) a significant reduction of scar width (15.7%) when compared with the same material used as a subcuticular suture for 3 weeks" 09/01/2004 - "The use of a deep 6/0 polydioxanon (PDS) suture significantly decreased the incidence of scar widening (p < 0.005).The columellar incision can be used safely in the Arab population regardless of their thick, dark, and oily skin" 01/01/2003 - "Several advantages were observed: shorter operative time, formation of a protective barrier, simplified incision care, no need for suture removal, and improved scar outcome" 01/01/2004 - "When the resulting defect is closed within the breast by strategically placed sutures, the base of the gland is narrowed, the breast is projected forward, and the circumareolar and vertical scars of other techniques are eliminated" 01/01/2006 - "The present study was conducted to compare single-layer interrupted sutures (Group A) with double-layer interrupted sutures (Group B) and our new method (Group C) as well as other perioperative parameters in relation to risk of wedge defects in scars" Order ALL the reference details at left...
4.	Solid-State Lasers 10/01/1997 - "Recently, the pulsed Er:YAG laser has been shown to be a highly effective treatment for several kinds of pitted facial scars" 01/01/2001 - "In agreement with previously reported studies our results show that multiple treatments with erbium YAG laser are safe and effective to improve atrophic scars." 12/01/2007 - "CONCLUSIONS: The 1,064 nm Nd:YAG laser is a safe and effective nonablative method for improving atrophic scars, even in darker skin." 07/01/2001 - "CONCLUSION: Er:YAG laser resurfacing may be safe and effective in the treatment of patients with DLE-induced atrophic scars." 03/01/2000 - "CONCLUSION: A pulsed erbium:YAG laser is an effective and safe treatment modality for scar revision." Order ALL the reference details at left...
5.	Transplantation (Transplant Recipients) 01/01/2007 - "We demonstrate that, in contrast to the other cell populations, transplantation of MAPCs significantly improved LV contractile function for at least 8 weeks post-transplantation and, although BMCs reduced infarct size, the decrease in scar size was substantially greater in MAPC-treated hearts" 03/02/2007 - "Real-time PCR for sry gene 4 days after transplantation (n=4/group) showed 1.93-fold higher survival of rSkMs in group 3 as compared with group 2. Four weeks later, echocardiography revealed improved indices of left ventricular function, including ejection fraction and fractional shortening in group 3 (P<0.02) as compared with groups 1 and 2. Blood vessel count per surface area (at x400 magnification) was highest in scar and periscar areas in group 3 as compared with the other groups (P<0.05)" 03/31/1997 - "Free fat transplantation can reduce the degree of dural scar tissue after operation for lumbal disc herniation, but does not result in a clinically better outcome." 05/01/1996 - "Free fat transplantation can reduced the degree of dural scar tissue after operation for lumbar disc herniation but does not result in a clinically better outcome." 05/28/2007 - "Compared with controls, BMC transplantation improved left ventricular ejection fraction (pooled difference, 3.66%; 95% confidence interval [CI], 1.93% to 5.40%; P<.001); reduced infarct scar size (-5.49%; 95% CI, -9.10% to -1.88%; P = .003); and reduced left ventricular end-systolic volume (-4.80 mL; 95% CI, -8.20 to -1.41 mL; P = .006)" Order ALL the reference details at left...

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