Chymopapain (Chymodiactin)

06/01/1986 - "Mechanism of action of intradiscal chymopapain in the treatment of sciatica: a clinical, biochemical, and radiological study."
08/10/1992 - "On the basis of these results, we shall continue to use chymopapain injection to treat selected patients with sciatica caused by herniated lumbar discs."
12/01/1988 - "In patients treated with chymopapain, unrelieved sciatica was the most common cause of clinical treatment failure. "
09/01/1986 - "The biochemistry of the action of chymopapain in relief of sciatica."
11/01/1982 - "Complete relief of sciatica was obtained in 63% of patients treated with chymopapain, compared with 27% of saline-injected patients. "

11/01/1986 - "Even though these findings could not be correlated with clinical success or failure using the criteria in this study, six of the original 39 patients were diagnosed as having free disk fragments on the basis of their initial MR scans, a fact that does have management implications for the use of chymopapain in treatment of herniated disk disease."
03/01/2005 - "Herniated discs after administration of MMP-7 and chymopapain showed a significant decrease in protruded mass 7 days after administration compared with saline-treated discs when evaluated by myelography (p<0.01). "
06/01/1999 - "A review was made of 85 patients who received a second injection of chymopapain because of a recurrent disc herniation between 1980 and 1996. "
02/15/1998 - "The use of chymopapain in the treatment of lumbar disc herniation has been widely studied since Smith first described its use in humans in 1963. "
02/01/1996 - "To establish whether chymopapain is as good as primary surgery in treating adolescents with proven lumbar disc protrusions. "

08/01/1985 - "Most cases of treatment failure could be attributed to an incorrect radiographic diagnosis, treatment of patients with equivocal diagnostic studies, the presence of "free" disk fragments, and causes of nerve-root compression unresponsive to chymopapain."
01/01/1975 - "Experimental studies on the effect of chymopapain on nerve root compression caused by intervertebral disk material."
01/01/1975 - "Since the primary effect of chymopapain is on the chondromucoprotein of the disk, beneficial results would not be expected if nerve root compression is due to bony impingement or scar tissue following previous surgery. "
07/01/1985 - "Ten normal adult volunteers, 75 patients with low back pain and/or lumbar radiculopathy, 16 patients following chymopapain treatment, 14 patients with recurrent symptoms following disc surgery, and two patients with distal cord compression were scanned on Fonar 3000 permanent magnet scanner. "

07/01/1986 - "No complications due to chymopapain toxicity were observed; 80.1% of patients were relieved of their presenting radicular leg pain and 75.1% were employed at a capacity equal to or more strenuous than before injection. "
05/01/1986 - "This study involves eight- to ten-year follow-up results of chymopapain injection for severe sciatic pain secondary to a herniating nucleus pulposus. "
01/01/1992 - "Three cases failed: 1 patient had previously been treated with chymopapain, while 3 are awaiting anterior fusion to treat persistent lumbar pain. "
05/01/1986 - "On a series of 165 patients injected with chymopapain in only one disc, discographic data were correlated with the result of the treatment on the root pain. "
03/01/1986 - "After one month, the intensity of lumbar pain decreased by 44% on average in the group treated by chymopapain, and by 0% in the placebo group. "

06/06/1970 - "On the basis of the early results of the use of intradiscal injection of chymopapain in 15 patients with degenerative lumbar disc disease, the following statements are warranted: The injection can be beneficial in selected patients with lumbar disc disease. "
08/01/1987 - "These results cast doubt on the long-term benefits of chymopapain in the treatment of lumbar disc disease."
12/01/1983 - "Late results of treatment of intervertebral disc disease with chymopapain."
12/01/1983 - "The treatment of lumbar intervertebral disc disease by the intradiscal injection of chymopapain."
06/01/1983 - "Chymopapain for herniated lumbar disc disease."