INFLAMMATION of the placental membranes (CHORION; AMNION) and connected tissues such as fetal BLOOD VESSELS and UMBILICAL CORD. It is often associated with intrauterine ascending infections during PREGNANCY.
Also Known As:
Amnionitides; Chorioamnionitides; Funisitides; Amnionitis; Funisitis
Networked: 1039 relevant articles (31 outcomes, 132 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1. Infection
2. Sepsis (Septicemia)
3. Rupture
4. Premature Birth (Birth, Premature)
5. Chorioamnionitis


1. Romero, Roberto: 38 articles (04/2014 - 06/2002)
2. Jobe, Alan H: 27 articles (01/2014 - 02/2003)
3. Kramer, Boris W: 24 articles (12/2013 - 04/2003)
4. Chaiworapongsa, Tinnakorn: 22 articles (04/2014 - 06/2002)
5. Hassan, Sonia S: 20 articles (04/2014 - 07/2008)
6. Kallapur, Suhas G: 20 articles (01/2014 - 03/2003)
7. Newnham, John P: 19 articles (05/2014 - 04/2003)
8. Yoon, Bo Hyun: 19 articles (04/2014 - 06/2002)
9. Nitsos, Ilias: 17 articles (05/2014 - 07/2003)
10. Kacerovsky, Marian: 16 articles (10/2014 - 01/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chorioamnionitis:
1. Anti-Bacterial Agents (Antibiotics)IBA
2. C-Reactive ProteinIBA
3. SteroidsIBA
4. MagnesiumIBA
02/01/2005 - "Multiple regression revealed a significant association between antepartum magnesium use and improved SNAP scores after controlling for gestational age, glucocorticoid use, chorioamnionitis, and birthweight (SNAP score reduction = -2.25 +/- 0.78, P = 0.005). "
05/01/1997 - "No significant reduction in risk of nondisabling CP (adjusted odds ratio [OR], 1.00; 95% confidence interval [CI], 0.53 to 1.88) or disabling CP [DCP] (adjusted OR, 0.63; 95% CI, 0.32 to 1.24) CP with magnesium exposure was found in a logistic regression model that controlled for gestational age, fetal growth, gender, multiple birth status, mode of delivery, amnionitis, and hypertensive disorders. "
05/01/2014 - "In models controlling for gestational age at delivery, maternal education, maternal race, tobacco/alcohol/drug use during pregnancy, randomization to magnesium, fetal sex, and chorioamnionitis, individual neonatal morbidities were moderately predictive of childhood neurodevelopmental impairment (best model area under receiver operating characteristic curve, 0.68; 95% confidence interval, 0.65-0.71). "
08/01/2002 - "There were no significant differences between groups with respect to neonatal outcomes, with the exception of an increased rate of clinical chorioamnionitis in the group exposed to magnesium for more than 24 h (22% vs. 8.2%, p = 0.005). "
10/01/2010 - "There were no significant differences between infants with histologic chorioamnionitis and infants without histologic chorioamnionitis in perinatal factors except for GA, pregnancy induced hypertension, and exposure to antenatal magnesium sulphate. "
Order ALL the reference details at left...
5. Ceftazidime (Fortum)FDA LinkGeneric
6. Gentamicins (Gentamicin)FDA LinkGeneric
7. Interleukin-6 (Interleukin 6)IBA
8. Biological Markers (Surrogate Marker)IBA
9. Glucose (Dextrose)FDA LinkGeneric
10. Hydrocortisone (Cortisol)FDA LinkGeneric

Therapies and Procedures

1. Tocolysis
2. Cesarean Section (Caesarean Section)
3. Prenatal Care
07/01/2008 - "Further studies are needed to determine the efficacy of early prenatal care in the control of anemia and to examine its affect on the incidence of chorioamnionitis."
06/01/1994 - " In conclusion, physical assault was associated with preterm labor and chorioamnionitis and screening for assault must be incorporated during routine prenatal care to identify women at risk of complications."
08/01/2010 - "Low education level was associated with a lack of prenatal care; induced abortion accounted for 34.6% of fetal deaths (gender selection was not the reason); 35.5% of infants were born at 22-28 weeks of gestation; 31.8% of stillbirths were small for gestational age; histologic evidence of chorioamnionitis was present in 40.2% of cases. "
05/01/1991 - "High-risk maternal transfer patients and patients with hypertension, toxemia, bacteriuria, pyelonephritis, renal failure, diabetes, anemia, polyhydramnios, oligohydramnios, prolapsed cord, vaginal bleeding, placenta previa, abruptio placentae, prolonged rupture of membranes, maternal fever on admission, amnionitis, sexually transmitted diseases, or fewer than five prenatal care visits were excluded. "
07/01/2009 - "Lack of prenatal care (odds ratio [OR], 1.94; 95% confidence interval [CI], 1.32-2.86), delivery room resuscitation (OR, 2.49; 95% CI, 1.91-3.24), membrane rupture > 24 hours without amnionitis (OR, 2.10; 95% CI, 1.53-2.88), amnionitis with membrane rupture < 24 hours (OR, 4.28; 95% CI, 2.97-6.16), and amnionitis with membrane rupture >or= 24 hours (OR, 8.15; 95% CI, 5.98-11.10) were associated with EOS, but not antenatal steroids or gestational age. "
Order ALL the reference details at left...
4. Antibiotic Prophylaxis
5. Neonatal Intensive Care

blog comments powered by Disqus
for Chorioamnionitis,
Ranking and Evidence
*WARNING* This specific disease subtype has a relatively small number of significant evidence outcomes. You may proceed to order anyway, or go back to the search field and enter a more general type of the target illness. Once your report has been ordered, however, we can't refund the purchase.

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. Analytic charts allow you and your physicians to see at a glance the treatment options—including new, promising, off-label and experimental.
  • Free Updates for 1 Year
  • All 31 Outcomes
  • Top 200 Key Drugs and Biologics
  • Top 50 Key Therapies and Procedures
  • Detailed History Charts
  • Full Research Evidence References
  • Sample PDF Report on Psoriasis >>
Price:$24.95 USD & Delivery via PDF download
updates for 1 year
Research Interface PRO

Rapidly retrieve clinical outcome summaries for all evidence of drug efficacy against any disease in seconds. Click "Charts" to view graphs of relative efficacy of all drugs against any known disease. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time. Save hours of search and analysis time:
Price:$490.00 USD access via web interface
1 year subscription
Request Bulk Institution License Details >>