INFLAMMATION of the placental membranes (CHORION; AMNION) and connected tissues such as fetal BLOOD VESSELS and UMBILICAL CORD. It is often associated with intrauterine ascending infections during PREGNANCY.
Also Known As:
Amnionitides; Chorioamnionitides; Funisitides; Amnionitis; Funisitis
Networked: 1055 relevant articles (31 outcomes, 132 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1. Infection
2. Sepsis (Septicemia)
3. Endometritis
4. Rupture
5. Premature Birth (Birth, Premature)


1. Romero, Roberto: 39 articles (01/2015 - 06/2002)
2. Jobe, Alan H: 27 articles (01/2014 - 02/2003)
3. Kramer, Boris W: 24 articles (12/2013 - 04/2003)
4. Chaiworapongsa, Tinnakorn: 23 articles (01/2015 - 06/2002)
5. Hassan, Sonia S: 21 articles (01/2015 - 07/2008)
6. Kallapur, Suhas G: 21 articles (12/2014 - 03/2003)
7. Yoon, Bo Hyun: 20 articles (01/2015 - 06/2002)
8. Newnham, John P: 19 articles (05/2014 - 04/2003)
9. Kacerovsky, Marian: 18 articles (03/2015 - 01/2009)
10. Hornychova, Helena: 18 articles (03/2015 - 01/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chorioamnionitis:
1. Anti-Bacterial Agents (Antibiotics)IBA
2. C-Reactive ProteinIBA
3. SteroidsIBA
4. Ceftazidime (Fortum)FDA LinkGeneric
5. Gentamicins (Gentamicin)FDA LinkGeneric
6. Interleukin-6 (Interleukin 6)IBA
7. Biological Markers (Surrogate Marker)IBA
06/01/2010 - "Despite the recent studies about the dosage of inflammatory biomarkers in the amniotic fluid or in fetal and maternal blood, placenta histology remains the gold standard for the diagnosis of chorioamnionitis. "
03/06/2015 - "We apply high-throughput amniotic fluid (AF) metabolomics analysis for better understanding the pathophysiological mechanism of chorioamnionitis and its associated perinatal neurological injury and to provide meaningful information about new potential biomarkers. "
03/06/2015 - "LC-MS-based metabolomics identification of novel biomarkers of chorioamnionitis and its associated perinatal neurological damage."
01/01/2014 - " additional projects investigating specific hypotheses among subsamples of the cohort by collecting specific data in addition to the core cohort data are being conducted to investigate 1) diagnosis of histologic chorioamnionitis, 2) early biomarkers of child health, 3) attitudes of care for extremely preterm infants, 4) painful procedures in neonatal intensive care units, 5) neonatal MRI cerebral abnormalities and their relation to executive functions, 6) associations between early gut colonization and early and late onset diseases, 7) impact of neonatal nutrition on child development, and 8) mother-infant attachment. "
11/01/2013 - "We suggest using pro-ADM and serum AA biomarkers for detecting the histological chorioamnionitis at an earlier stage in PPROM without any clinical signs. "
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8. Hydrocortisone (Cortisol)FDA LinkGeneric
9. Glucose (Dextrose)FDA LinkGeneric
10. MagnesiumIBA

Therapies and Procedures

1. Tocolysis
2. Cesarean Section (Caesarean Section)
3. Prenatal Care
07/01/2008 - "Further studies are needed to determine the efficacy of early prenatal care in the control of anemia and to examine its affect on the incidence of chorioamnionitis."
06/01/1994 - " In conclusion, physical assault was associated with preterm labor and chorioamnionitis and screening for assault must be incorporated during routine prenatal care to identify women at risk of complications."
08/01/2010 - "Low education level was associated with a lack of prenatal care; induced abortion accounted for 34.6% of fetal deaths (gender selection was not the reason); 35.5% of infants were born at 22-28 weeks of gestation; 31.8% of stillbirths were small for gestational age; histologic evidence of chorioamnionitis was present in 40.2% of cases. "
04/01/2014 - "Pre hospitalization maternal factors (age, pregnancy, health insurance, education, prenatal care, marital status, history of preeclampsia, prolonged rupture of membranes, chorioamnionitis infection) and neonatal ones (age at admission, gestational age, birth weight, gender, delivery practice, route of admission, Apgar and type of resuscitation) that were associated with prolonged hospital stay were analyzed. "
05/01/1991 - "High-risk maternal transfer patients and patients with hypertension, toxemia, bacteriuria, pyelonephritis, renal failure, diabetes, anemia, polyhydramnios, oligohydramnios, prolapsed cord, vaginal bleeding, placenta previa, abruptio placentae, prolonged rupture of membranes, maternal fever on admission, amnionitis, sexually transmitted diseases, or fewer than five prenatal care visits were excluded. "
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4. Antibiotic Prophylaxis
5. Neonatal Intensive Care

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for Chorioamnionitis,
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