|3.||Osteosarcoma (Osteogenic Sarcoma)
|4.||Sarcoma (Soft Tissue Sarcoma)
|1.||Tang, Chih-Hsin: 50 articles (11/2015 - 03/2008)|
|2.||Fong, Yi-Chin: 39 articles (11/2015 - 11/2004)|
|3.||Bovée, Judith V M G: 22 articles (04/2015 - 03/2005)|
|4.||Hogendoorn, Pancras C W: 19 articles (04/2013 - 02/2004)|
|5.||Takigawa, Masaharu: 15 articles (02/2011 - 01/2002)|
|6.||Yang, Wei-Hung: 13 articles (12/2014 - 02/2009)|
|7.||Debus, Jürgen: 13 articles (07/2014 - 05/2002)|
|8.||Li, Te-Mao: 12 articles (11/2015 - 12/2008)|
|9.||Hsu, Chin-Jung: 11 articles (05/2015 - 08/2007)|
|10.||Scully, Sean P: 11 articles (04/2011 - 07/2002)|
01/01/2000 - "Proton irradiation is also effective for base of skull chondrosarcomas. "
01/01/2010 - "Proton therapy is the gold standard in the treatment of skull base chondrosarcomas. "
04/01/2010 - "and D.A.), by applying the key words "skull base", "chondrosarcoma", and "proton therapy" selected those studies from the PubMed database in which a minimum of ten patients received palliative, radical, or postoperative irradiation with protons and which furnished a minimum of 24 months of follow-up. "
01/01/2013 - "Dosimetric comparison of photon and proton treatment techniques for chondrosarcoma of thoracic spine."
04/01/2010 - "A systematic review of proton therapy in the treatment of chondrosarcoma of the skull base."
01/01/2007 - "Carbon ion RT is an effective treatment for low- and intermediate-grade chondrosarcomas of the skull base offering high local control rates with low toxicity."
05/15/2014 - "Carbon ion therapy is a safe and effective treatment in patients with chondrosarcoma of the skull base. "
05/15/2014 - "High control rate in patients with chondrosarcoma of the skull base after carbon ion therapy: first report of long-term results."
01/01/2007 - "Between November 1998 and September 2005, 54 patients with low-grade and intermediate-grade chondrosarcomas of the skull base have been treated with carbon ion radiation therapy (RT) using the raster scan technique at the Gesellschaft für Schwerionenforschung in Darmstadt, Germany. "
01/01/2007 - "To evaluate the effectiveness and toxicity of carbon ion radiotherapy in chondrosarcomas of the skull base. "
|3.||DNA (Deoxyribonucleic Acid)IBA
02/01/2000 - "Cytometric DNA measurement provide additional objective information regarding the diagnosis and prognosis of chondrosarcomas, even more than that obtained by conventional histopathologic grading, and may be helpful in planning the treatment."
09/15/2013 - "In this study, we performed genome-wide CpG methylation sequencing of chondrosarcoma biopsies and found that IDH mutations were associated with DNA hypermethylation at CpG islands but not other genomic regions. "
01/01/2014 - "No second mutational hit was detected in the DNA of the secondary chondrosarcoma from a patient who carried a nonsense EXT1 mutation. "
07/01/2013 - "DNA mutation testing using EBUS-TBNA samples was first reported in 2007 for a chondrosarcoma case. "
04/15/2009 - "Hence, we have investigated DNA copy numbers in chondrosarcomas with the purpose of identifying markers useful for prognosis and subclassification. "
03/01/2012 - "Sulfated chitooligosaccharide II (SCOS II) suppress collagen degradation in TNF-induced chondrosarcoma cells via NF-κB pathway."
03/01/2009 - "Chondrosarcomas are distinguished by high expression of type IX and XI collagen. "
07/01/2007 - "A myxoid matrix consisting of thin collagen fibrils on the background of pericellular type PG suggested that the myxoid matrix in the chondrosarcoma resembled those of the pericellular and pericellular sides of the territorial matrices in normal cartilage."
04/01/2006 - "Rat 1 fibroblasts and human chondrosarcoma cells were used as positive models for types I and II collagen, respectively. "
06/01/2005 - "Finally, it is found that chondrosarcoma cells spread well and synthesize extracellular matrix components only on the collagen ending films, whereas no cellular matrix was found for HA ending ones. "
08/01/2006 - "These studies demonstrate the differential inhibition of cytokine-induced MMP-1 and -13 expression by p38 kinase inhibitors in human chondrosarcoma cells. "
12/01/2002 - "Therefore, our study represents the first report that CD44 stimulation induced by a fragmented HA results in activation of MAP kinase and, subsequently, enhances uPA and uPAR expression and facilitates invasion of human chondrosarcoma cells."
09/03/2013 - "Our aim was to investigate the role of these kinases in chemoresistance and migration in chondrosarcoma in relation to TP53 mutation status. "
09/03/2013 - "Previously, PI3K/AKT/GSK3β and Src kinase pathways were shown to be activated in chondrosarcoma cell lines. "
08/01/2006 - "To investigate mitogen activated protein (MAP) kinase pathways for their ability to differentially regulate the expression of matrix metalloprotease (MMP)-1 and -13 in human chondrosarcoma cells using pathway-selective inhibitors. "
|6.||Doxorubicin (Adriamycin)FDA LinkGeneric
06/01/2014 - "Finally, we reported a synergistic effect produced by incorporating doxorubicin with glycolysis inhibitors-oxamate in the combined treatment of chondrosarcoma cells in vitro and in vivo. "
06/01/2014 - "To further explore the mechanisms, we generated doxorubicin-resistant cells from SW1353 chondrosarcoma cell line. "
06/01/2014 - "Moreover, chondrosarcoma cells exhibited elevated levels of LDHA expression under doxorubicin treatment. "
11/01/2012 - "Moreover, LRF depletion not only drastically reduces the cellular migration and invasion potentials of chondrosarcoma cells but also sensitized these cells to the apoptosis-inducing chemotherapeutic agent doxorubicin. "
06/01/2012 - "3D cell pellets, morphologically strongly resembling chondrosarcoma in vivo, confirmed nuclear incorporation of doxorubicin. "
02/01/2009 - "g., low-grade chondrosarcoma, central low-grade osteosarcoma, parosteal osteosarcoma, well-differentiated liposarcoma, and dermatofibrosarcoma protuberans, are well cured only by surgical excision, and adjuvant chemotherapy is therefore not indicated. "
01/01/2011 - "Myxoid soft-tissue sarcomas represent a heterogeneous group of mesenchymal tumors characterized by a predominantly myxoid matrix, including myxoid liposarcoma (MLS), low-grade fibromyxoid sarcoma (LGFMS), extraskeletal myxoid chondrosarcoma (EMC), myxofibrosarcoma, myxoinflammatory fibroblastic sarcoma (MIFS), and myxoid dermatofibrosarcoma protuberans (DFSP). "
10/01/1999 - "Histologically, the tumor included four histological patterns; a malignant fibrous histiocytoma-like, a desmoid-like, a dermatofibrosarcoma protuberans-like, and a chondrosarcoma-like pattern. "
01/01/1988 - "This comparative analysis of the characteristic ultrastructural features specific for intramuscular myxoma, myxoid liposarcoma, extraskeletal myxoid chondrosarcoma, myxoid malignant fibrous histiocytoma, myxoid variant of dermatofibrosarcoma protuberans, and myxoid neurilemmoma is based on our own studies of 52 cases. "
09/01/1992 - "Four MFHs and nine other types of sarcoma (four leiomyosarcomas, two chondrosarcomas, one liposarcoma, one fibrosarcoma, and one dermatofibrosarcoma protuberans) showed nuclear positivity for p53. "
|8.||Nitric Oxide (Nitrogen Monoxide)FDA Link
04/19/2013 - "Fuyuan Decoction inhibits nitric oxide production via inactivation of nuclear factor-κB in SW1353 chondrosarcoma cells."
11/01/1998 - "Because the chondrosarcoma of the Swarm rat is a well differentiated solid tumor that rarely metastasizes, nitric oxide may be produced by the tumor to promote local growth by effects on vascular supply."
10/05/2010 - "In this study, we investigated the effects of E2 and BPA on nitric oxide (NO) production, NF-kappaB activation, and MMP-1 expression in chondrosarcoma SW1353 cells and primary human osteoarthritic chondrocytes. "
11/01/1998 - "Up-regulation of inducible nitric oxide synthase and production of nitric oxide by the Swarm rat and human chondrosarcoma."
11/01/1998 - "This study demonstrated that the chondrosarcoma of the Swarm rat has upregulated mRNA for inducible nitric oxide synthase and produces nitric oxide. "
|9.||Parathyroid Hormone-Related ProteinIBA
09/25/2003 - "Our results suggest the possibility that anti-PTHrP MoAb may be beneficial as a new treatment for chondrosarcoma."
01/01/2014 - "The objectives of this study were to research the function played by PTHrP in human chondrosarcoma, especially targeting cell proliferation and invasion, and to search for the potential interaction between PTHrP and primary cilia in tumorigenesis. "
04/01/2014 - "These early-stage mutations, found in both benign cartilaginous lesions and chondrosarcomas, include alterations affecting the IHH/PTHrP and IDH1/IDH2 pathways. "
01/01/2014 - "Thus, restricting PTHrP over-expression is a feasible potential therapeutic method for chondrosarcoma. "
01/01/2007 - "Since proliferation is the hallmark of chondrosarcoma cells, we hypothesized that Ihh/PTHrP and FGF3R pathways may be dysfunctional on these cells. "
05/15/2014 - "The current study was performed to evaluate the safety and effectiveness of irradiation with carbon ions using raster scanning as well as prognostic factors in patients with skull base chondrosarcomas. "
05/15/2014 - "Between 1998 and 2008, 79 patients with chondrosarcoma of the skull base were treated using carbon ions in raster scanning. "
07/01/2014 - "Reirradiation with carbon ions is a safe and effective method in patients with relapsed chordoma and chondrosarcoma of the skull base."
07/01/2014 - "To evaluate the safety and efficacy of reirradiation with carbon ions in patients with relapse of skull base chordoma and chondrosarcoma. "
07/01/2014 - "Reirradiation with carbon ions was performed on 25 patients with locally recurrent skull base chordoma (n = 20) or chondrosarcoma (n = 5). "
|1.||Drug Therapy (Chemotherapy)
01/01/2010 - "Extraskeletal myxoid chondrosarcoma: a case report of complete remission by chemotherapy and review of the literature."
06/01/2009 - "Conventional chemotherapy is ineffective for high-grade chondrosarcomas, highlighting the need for improved chemotherapies. "
01/01/2011 - "These studies have shown that spinal chondrosarcomas require complete surgical resection and are notoriously resistant to chemotherapy and radiation. "
08/01/2015 - "Metastatic chondrosarcoma of mesenchymal origin is the second most common bone malignancy and does not respond either to chemotherapy or radiation; therefore, the search for new therapies is relevant and urgent. "
01/01/2015 - "Since radiation therapy and chemotherapy have limited effect on chondrosarcoma, treatment of most patients depends on surgical resection. "
01/01/1998 - "The authors report the first case of chondrosarcoma of the larynx in which radical radiotherapy resulted in a long term remission of more than 10 years. "
01/01/1998 - "Meanwhile, increasing evidence of the efficacy of radiotherapy in the treatment of skeletal chondrosarcoma has emerged. "
06/01/2011 - "A study was undertaken to evaluate results of surgery and radiotherapy (RT) for high-risk extracranial chondrosarcomas. "
01/01/1998 - "In this study, radiotherapy appeared to be an effective modality in the treatment of low grade laryngeal chondrosarcoma, and these results contrast with the current widespread disapproval of this treatment."
05/01/2014 - "These cases highlight the risk of secondary chondrosarcoma in patients following radiotherapy and the importance of lifetime monitoring."
06/01/2015 - "Low-grade chondrosarcoma of long bones can be treated successfully with extended intralesional curettage using adjuvants. "
01/01/2012 - "A basic science study was performed at respectively 16 and 10 patients, treated by intralesional curettage and adjuvant therapy for low-grade central chondrosarcoma of bone. "
10/01/2015 - "In contrast, low-grade chondrosarcoma of appendicular skeleton could be treated safely by intralesional curettage. "
06/01/2015 - "Anhydrous alcohol is a reasonable adjuvant for the curettage of low-grade chondrosarcoma of long bones. "
06/01/2015 - "We asked (1) whether intralesional curettage and anhydrous alcohol adjuvant for low-grade chondrosarcoma is associated with good oncologic outcomes; and we report (2) the complications of the procedure. "
01/01/2005 - "Comparison of functional results with data from studies shows that these results concur with other studies on cryosurgery, and are at least equal to results of marginal excision and mostly better than those of wide excisions of grade 1 chondrosarcomas. "
01/01/2011 - "The value of cryosurgery in treating a case of thoracic chondrosarcoma."
10/01/2006 - "In this small group of patients, intralesional resection with adjuvant cryoablation provided an alternative to more radical procedures for low-grade intracompartmental chondrosarcoma."
10/01/2006 - "Influence of cryosurgery on treatment outcome of low-grade chondrosarcoma."
01/01/2005 - "It is used in benign, aggressive, and low-grade malignant bone tumours such as chondrosarcoma grade 1. We describe the history of the technique and the issues associated with cryobiology, as well as the indications, technique, complications, and results of cryosurgery. "
11/01/2008 - "No local recurrences after treatment of chondrosarcoma grade 1 were seen. "
02/01/1981 - "Primary malignant tumours require pre-treatment and after-treatment by chemotherapy (with the exception of chondrosarcoma) in order to meet the demand of oncological radicality. "
01/01/1986 - "Chondrosarcoma of the thumb: an unusual case with lung and cutaneous metastases and death of the patient 6 years after treatment."
07/01/1984 - "The authors report a case of chondrosarcoma arising in the cerebellum 16 years after treatment of a cerebellar malignant astrocytoma by subtotal resection and irradiation. "
04/01/1976 - "Measurements were made of the 35S content of tissues obtained from biopsies and autopsies made during and up to 6 months after treatment of chondrosarcoma or chordoma with carrier-free Na235SO4. "