Chondroitin Sulfates (Chondroitin Sulfate)

Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.

Also Known As:

Chondroitin Sulfate; Blutal; Chondroitin 4-Sulfate, Aluminum Salt; Chondroitin 4-Sulfate, Potassium Salt; Chondroitin 6-Sulfate, Potassium Salt; Chondroitin 6-Sulfate, Sodium Salt; Chondroitin Sulfate 4-Sulfate, Sodium Salt; Chondroitin Sulfate, Calcium Salt; Chondroitin Sulfate, Iron (+3) Salt; Chondroitin Sulfate, Iron Salt; Chondroitin Sulfate, Potassium Salt; Chondroitin Sulfate, Sodium Salt; Chondroitin Sulfate, Zinc Salt; Chonsurid; Sodium Chondroitin Sulfate; Translagen; Chondroitin 4 Sulfate; Chondroitin 4 Sulfate, Aluminum Salt; Chondroitin 4 Sulfate, Potassium Salt; Chondroitin 6 Sulfate; Chondroitin 6 Sulfate, Potassium Salt; Chondroitin 6 Sulfate, Sodium Salt; Chondroitin Sulfate 4 Sulfate, Sodium Salt; Chondroitin Sulfate, Sodium; Sulfate, Chondroitin; Sulfate, Sodium Chondroitin; Sulfates, Chondroitin; Chondroitin 4-Sulfate; Chondroitin 6-Sulfate; Chondroitin Sulfate A; Chondroitin Sulfate C; Chondroitin, hydrogen sulfate

Networked: 1594 relevant articles (97 outcomes, 224 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Glycosaminoglycans: 5640
    - Chondroitin: 773
      - Chondroitin Sulfates: 1594
        danaparoid: 816
        O-(glucuronic acid 2-sulfate)-(1--3)-O-(2,5)-andydrotalitol 6-sulfate: 602
        sodium hyaluronate drug combination chondroitin sulfate: 50
        fucosylated chondroitin sulfate: 23
        chondroitin sulfate glycosaminoglycan: 20
        Optisol: 20
        integra artificial skin: 16
        Biopex: 5
        dermatan sulfate chondroitin sulfate: 5
        eleparon: 4
        SSHA: 3
        Biodritin: 2
        chondroitin sulfate E hexasaccharide: 1
        K-Sol preserving medium: 1
        6-sulfo-N-acetylgalactosamineglucuronic acid 6- sulfo-N-acetylgalactosaminitol
        Chen medium
        chondroitin 4,6-disulfate
        chondroitin sulfate D
        chondroitin sulfate succinimidyl succinate
        chondroitin sulfate trisaccharide
        Dexsol
        DSD-1-proteoglycan
        Nephrotic Syndrome Defective Cellular Immunity Chondroitin-6-Sulfaturia
        OK205 Korean medicine
        peptidochondroitin sulfate
        poly(L-lactide)-graft-chondroitin sulfate

Experts

1.	Salanti, Ali: 30 articles (12/2021 - 07/2003)
2.	Sugahara, Kazuyuki: 17 articles (01/2016 - 01/2004)
3.	van Kuppevelt, Toin H: 15 articles (03/2020 - 06/2003)
4.	Schiraldi, Chiara: 14 articles (09/2022 - 02/2012)
5.	Theander, Thor G: 14 articles (12/2021 - 07/2003)
6.	Volpi, Nicola: 14 articles (12/2020 - 06/2004)
7.	Vergés, Josep: 14 articles (06/2017 - 01/2004)
8.	Reginster, Jean-Yves: 13 articles (05/2021 - 07/2003)
9.	Nielsen, Morten A: 12 articles (01/2021 - 02/2008)
10.	Duffy, Patrick E: 11 articles (01/2022 - 07/2002)

Related Diseases

1.	Osteoarthritis 03/01/2008 - "Exogenous administration of chondroitin sulfate (CS) is widely practiced for the treatment of osteoarthritis, although the efficacy of this treatment has not been completely established by clinical studies. " 04/26/2017 - "Is chondroitin sulfate effective for osteoarthritis?" 03/01/2013 - "Chondroitin sulfate is an effective and safe treatment option for patients with osteoarthritis." 01/01/2012 - "To perform a meta-analysis of randomized double-blind placebo-controlled clinical trials to assess the efficacy of a specific chondroitin sulfate preparation (Structum®, Laboratoires Pierre Fabre, Castres; France) as a symptom-modifying drug in osteoarthritis (OA) of the knee. " 01/01/2000 - "To examine the efficacy of chondroitin sulfate (CS) in the treatment of osteoarthritis (OA) on the basis of a metaanalysis of controlled clinical trials. "
2.	Knee Osteoarthritis 01/01/2018 - "Chondroitin sulfate is superior to placebo in symptomatic knee osteoarthritis." 03/01/2005 - "To determine whether chondroitin sulfate (CS) is effective in inhibiting cartilage loss in knee osteoarthritis (OA). " 01/01/2019 - "Efficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials." 06/01/2010 - "To update a published meta-analysis of double-blind placebo-controlled randomized clinical trials (RCTs) to assess the efficacy of chondroitin sulfate as a structure-modifying drug for knee osteoarthritis (OA). " 02/01/2018 - "Efficacy of Chondroitin Sulfate for Painful Knee Osteoarthritis: A One-Year, Randomized, Double-Blind, Multicenter Clinical Study in Japan."
3.	Pain (Aches) 03/01/2013 - "Clinical trials have reported a beneficial effect of chondroitin sulfate on pain and function. " 05/01/1999 - "All four studies showed chondroitin sulfate to be superior to placebo, with respect to Lequesne index, visual analog scale for pain and medication consumption. " 05/01/1998 - "This limited study confirmed that chondroitin sulfate was well-tolerated and both significantly reduced pain and increased overall mobility capacity. " 01/01/2021 - "Pharmaceutical-grade chondroitin sulfate (CS) was repeatedly reported to reduce pain and improve function in patients with OA. " 01/01/2020 - "Administration of chondroitin sulfate is associated with reduced local pain syndrome and functional normalization of musculoskeletal system. "
4.	Interstitial Cystitis (Interstitial Cystitis, Chronic) 02/01/2002 - "The efficacy of chondroitin sulfate 0.2% in treating interstitial cystitis." 09/01/2013 - "To assess the response of patients diagnosed with painful bladder syndrome to treatment with instillations of sodium chondroitin sulfate. " 09/01/2013 - "Long-term experience with sodium chondroitin sulfate in patients with painful bladder syndrome." 06/01/2012 - "To gain additional safety and effectiveness information regarding intravesical 2% chondroitin sulfate in subjects with interstitial cystitis/bladder pain syndrome (IC/BPS) in a controlled clinical trial. " 06/01/2012 - "Second multicenter, randomized, double-blind, parallel-group evaluation of effectiveness and safety of intravesical sodium chondroitin sulfate compared with inactive vehicle control in subjects with interstitial cystitis/bladder pain syndrome."
5.	Urinary Tract Infections (Urinary Tract Infection) 06/15/2023 - "Cranberry/Chondroitin Sulfate Co-precipitate as a New Method for Controlling Urinary Tract Infections." 01/01/2021 - "Additionally, we present the first known report of chondroitin sulfate degradation by Proteus mirabilis, an important uropathogen and a causative agent of acute, recurrent, and catheter-associated urinary tract infections (CAUTI). " 12/01/2012 - "Editorial comment to intravesical hyaluronic acid and chondroitin sulfate alone and in combination for urinary tract infection: assessment of protective effects in a rat model." 12/01/2012 - "To determine the protective effects of hyaluronic acid and chondroitin sulfate in treating urinary tract infections in a rat model. " 12/01/2012 - "Intravesical hyaluronic acid and chondroitin sulfate alone and in combination for urinary tract infection: assessment of protective effects in a rat model."

Related Drugs and Biologics

1.	Glucosamine (Dona)
2.	Hyaluronic Acid (Hyaluronan)
3.	Chondroitin
4.	Chondroitin Sulfates (Chondroitin Sulfate)
5.	Curcumin
6.	Chitosan
7.	Collagen Type II (Type II Collagen)
8.	Peptides (Polypeptides)
9.	Antibodies
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravesical Administration
3.	Radiotherapy
4.	Ligation
5.	Intravenous Administration