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Chondroitin

A mucopolysaccharide constituent of chondrin. (Grant & Hackh's Chemical Dictionary, 5th ed)
Networked: 545 relevant articles (34 outcomes, 91 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Kitagawa, Hiroshi: 6 articles (12/2015 - 05/2003)
2. White, Emily: 6 articles (01/2015 - 05/2009)
3. Salanti, Ali: 5 articles (01/2015 - 07/2003)
4. Lampe, Johanna W: 5 articles (01/2015 - 09/2011)
5. Fawcett, James W: 5 articles (01/2012 - 04/2002)
6. Reda, Domenic J: 5 articles (08/2010 - 02/2004)
7. Theander, Thor G: 4 articles (01/2015 - 07/2003)
8. Kantor, Elizabeth D: 4 articles (01/2015 - 12/2012)
9. Venkatesan, Narayanan: 4 articles (03/2014 - 08/2006)
10. Klüppel, Michael: 4 articles (01/2014 - 01/2010)

Related Diseases

1. Osteoarthritis
2. Pain (Aches)
05/01/2007 - "This study failed to show an efficacy of chondroitin sulphate on the two primary criteria considered together, although chondroitin sulphate was slightly more effective than placebo on pain, OMERACT-OARSI response rate, investigator's assessment and quality of life."
07/14/2003 - "Chondroitin was found to be effective on Lequesne Index, visual analog scale pain, mobility, and responding status. "
05/01/2007 - "At the end of treatment, the decrease in pain was -26.2 (24.9) and -19.9 (23.5) mm and improved function was -2.4 (3.4) (-25%) and -1.7 (3.3) (-17%) in the chondroitin sulphate and placebo groups, respectively (p = 0.029 and 0.109). "
01/01/2015 - " beneficial effects of chondroitin in pain and Lequesne's index persisted when evidence was limited to studies with adequate blinding or studies that used appropriate intention to treat (ITT) analyses. These beneficial effects were uncertain when we limited data to studies with appropriate allocation concealment or a large study sample (> 200) or to studies without pharmaceutical funding. "
01/01/2015 - "Participants treated with chondroitin achieved statistically significantly and clinically meaningful better pain scores (0-100) in studies less than 6 months than those given placebo with an absolute risk difference of 10% lower (95% confidence interval (CI), 15% to 6% lower; number needed to treat (NNT) = 5 (95% CI, 3 to 8; n = 8 trials) (level of evidence, low; risk of bias, high); but there was high heterogeneity between the trials (T(2) = 0.07; I(2) = 70%, which was not easily explained by differences in risk of bias or study sample size). "
3. Knee Osteoarthritis
4. Interstitial Cystitis (Interstitial Cystitis, Chronic)
5. Arthritis (Polyarthritis)

Related Drugs and Biologics

1. Glucosamine (Dona)
2. Hyaluronic Acid (Hyaluronan)
3. Chondroitin Sulfates (Chondroitin Sulfate)
4. Sodium
5. Heparin (Liquaemin)
6. Collagen Type II (Type II Collagen)
7. Capsaicin (Zostrix)
8. Calcium
9. Vitamin E
10. Quercetin

Related Therapies and Procedures

1. Intra-Articular Injections
2. Intravesical Administration
3. Drug Therapy (Chemotherapy)
4. Radiotherapy
5. Oral Administration