Chondroblastoma

A usually benign tumor composed of cells which arise from chondroblasts or their precursors and which tend to differentiate into cartilage cells. It occurs primarily in the epiphyses of adolescents. It is relatively rare and represents less than 2% of all primary bone tumors. The peak incidence is in the second decade of life; it is about twice as common in males as in females. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1846)

Also Known As:

Networked: 228 relevant articles (15 outcomes, 25 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasm Metastasis (Metastasis)
2.	Neoplasms (Cancer)
3.	Osteosarcoma (Osteogenic Sarcoma)
4.	Chondrosarcoma
5.	Osteoblastoma

Experts

1.	Gambarotti, Marco: 4 articles (09/2021 - 10/2017)
2.	Fang, Dong: 4 articles (01/2021 - 06/2016)
3.	Ueda, Takafumi: 3 articles (12/2021 - 05/2006)
4.	Righi, Alberto: 3 articles (09/2021 - 10/2017)
5.	Gulia, Ashish: 3 articles (04/2021 - 02/2020)
6.	Zhang, Zhiguo: 3 articles (01/2018 - 06/2016)
7.	Amary, M Fernanda: 3 articles (07/2016 - 12/2013)
8.	Baumhoer, Daniel: 3 articles (07/2016 - 12/2013)
9.	Flanagan, Adrienne M: 3 articles (07/2016 - 12/2013)
10.	Tirabosco, Roberto: 3 articles (07/2016 - 12/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chondroblastoma:

1.	Phenol (Carbolic Acid)FDA Link 11/01/1996 - "Local treatment with phenol is often used after intralesional excision of chondroblastomas and giant-cell tumours which involve bone near joints, and has been shown to reduce the rate of recurrence. " 09/01/2019 - "The aggressive treatment of chondroblastoma by an extended intralesional curettage using high-speed burr with phenol as a local adjuvant seems effective in lowering the incidence of local recurrence and secondary more aggressive surgeries. " 09/01/2019 - "Surgical treatment of chondroblastoma using extended intralesional curettage with phenol as a local adjuvant." 01/01/2017 - "Methods: We present a case of a recurrent chondroblastoma in the capitate that was treated with repeat curettage, application of phenol, and bone grafting. " 09/01/1985 - "The results have been analysed of 165 benign bone tumours capable of local recurrence (aneurysmal bone cyst, chondroblastoma, giant cell tumour) treated with and without the use of phenol. "
2.	DenosumabFDA Link 01/01/2021 - "Treatment of Chondroblastoma with Denosumab: A Case Report with a Correlative Analysis of Effect on the RANK Signaling Pathway." 04/01/2017 - "We report a case of recurrent chondroblastoma of the squamous temporal bone that is currently suppressed with denosumab." 04/01/2017 - "Use of denosumab in recurrent chondroblastoma of the squamous temporal bone: a case report." 01/01/2021 - "We confirm that denosumab treatment can be effective in controlling chondroblastoma metastasis and it has been a safe procedure in an adolescent patient." 01/01/2021 - "This patient's clinical response and effect on cellular RANK/RANK-L activity support the consideration of denosumab in the treatment algorithm for other osteolytic bone tumors such as chondroblastoma."
3.	Muramidase (Lysozyme)IBA 09/01/1995 - "Immunohistochemistry thus helped to distinguish chondroblastoma and osteosarcoma, in which lysozyme positivity would reside in macrophages but not within stromal cells. " 05/01/1993 - "The observation of positive reaction to S-100 protein (S-100), vimentin (Vim), alpha 1-antichymotrypsin (AACT) and lysozyme (Lyso) by the tumor cells of clear cell chondrosarcoma, similar to traditional chondrosarcoma and chondroblastoma, proves that this tumor has its origin in the cartilaginous tissue. " 07/01/1991 - "The observation of positive reaction to S-100 protein, vimentin, anti-alpha-chymotrypsin and Lysozyme by the tumor cells of clear cell chondrosarcoma, similar to chondrosarcoma and chondroblastoma, proves that this tumor has its origin from the cartilaginous tissue. "
4.	CalponinsIBA 07/01/2009 - "A convincing immunoreactivity for calponin and/or actin in chondromyxoid fibromas and chondroblastomas may also be helpful in differentiating these tumors from chondrosarcomas." 02/01/2011 - "Cytokeratin-, calponin-, and p63-positive chondroblastoma with extensive soft tissue involvement and vascular invasion: a potential diagnostic dilemma." 07/01/2009 - "Archival material from three extraskeletal myxoid chondrosarcomas, five chordomas, five chondromyxoid fibromas, five chondroblastomas and 25 chondrosarcomas was stained with antibodies against osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit) and YKL-40. " 04/01/2003 - "The expression of alpha smooth muscle actin, muscle specific actin, desmin, h-caldesmon, and calponin was studied immunohistochemically in the following soft tissue and bone tumours and tumour-like lesions: muscle fibromatosis, inflammatory pseudotumours, chondroblastoma, enchondroma, chondrosarcoma, fibrous dysplasia, ossifying myositis, osteoblastoma, convential osteosarcoma, leiomyoma and leiomyosarcoma. "
5.	MethacrylatesIBA 09/01/2011 - "Surgical treatment of chondroblastoma, using intralesional resection, adjuvant electrocauterization and replacement with methyl methacrylate or bone graft produced good results."
6.	S100 Proteins (S 100 Protein)IBA 02/01/2020 - "The present study was undertaken to evaluate IHC expression of S100 protein, DOG1 and p63 in 36 chondroblastomas. " 02/14/2011 - "Based on preoperative immunochemical studies showing positive reaction of multinucleated giant cells for S-100 protein, the final diagnosis was chondroblastoma. " 02/01/2020 - "S100 protein and DOG1 can be utilized for a confirmatory diagnosis of a chondroblastoma, especially for differentiating it from its other differentials, such as GCTB, in view of certain associated therapeutic implications. " 01/01/1996 - "Although the histogenesis of chondroblastoma is not completely understood, morphological findings as well as the observed reactivity with the S 100 protein indicate the chondroid origin. " 03/01/1985 - "These results suggest that immunohistochemical assessment of S-100 protein may be a method for diagnostically separating chondroblastoma from pathologic entities that could be histologically confused with it in the presence of limited biopsy material. "
7.	Histones (Histone)IBA 06/01/2023 - "Immunohistochemistry was performed using anti-histone antibody H3.3K36M in 44 histologically diagnosed chondroblastoma and 92 other histological mimickers. " 06/01/2023 - "To analyze the immunohistochemical expression of anti-histone H3F3K36M antibody inchondroblastoma and validate its utility in differentiating chondroblastoma from its histological mimics. " 06/01/2023 - "Anti-histone H3.3K36M Antibody is a Highly Sensitive and Specific Immunohistochemistry Marker for the Diagnosis of Chondroblastoma. " 01/01/2021 - "However, it's still unclear how the H3K36M mutation preferentially occurs in the histone H3 variant H3.3 in chondroblastomas. " 01/01/2020 - "In chondroblastoma and giant cell tumour of bone, the neoplastic mononuclear stromal-like cells frequently harbour specific point mutations in the genes encoding for histone H3.3 (H3F3A and H3F3B). "
8.	Collagen Type II (Type II Collagen)IBA 02/01/2006 - "In contrast, immunohistochemical analysis failed to show staining of collagen type II in any of the 35 chondroblastomas. " 09/01/2002 - "Immunohistochemically, the expression of type II collagen was diffuse in 15 cases (75%) among total 20 chondroblastomas and 12 (85.7%) among total 14 CMFs. " 12/01/1999 - "An extensive analysis of the extracellular matrix composition and gene expression pattern of a large series of chondroblastoma cases shows, however, that type II collagen, which is the main component of any cartilage matrix, is not expressed by the neoplastic cells of this tumour entity and is not deposited into the extracellular tumour matrix. " 02/01/2006 - "Therefore, our data show that in cases when clear cell chondrosarcoma and chondroblastoma pose a diagnostic challenge, the presence of type II collagen in the extracellular tumour matrix significantly supports the diagnosis of clear cell chondrosarcoma and aids in distinguishing it from chondroblastoma." 02/01/2010 - "The matrices of 7 chondroblastomas and of 8 chondromyxoid fibromas were immunopositive for collagen type II. The findings suggest the cartilaginous differentiation of chondroblastoma and chondromyxoid fibroma."
9.	AntibodiesIBA 08/01/2023 - "Chondroblastoma of foot bones; a clinicopathological study of 29 cases confirming the diagnostic utility of H3K36M and H3G34W antibodies at an uncommon site." 06/01/2012 - "  Nine chondroblastomas were analysed using immunohistochemical antibodies [CD34, α-smooth muscle actin (α-SMA), DOG1, CD117, AE1/AE3 and CD163]. " 11/01/2012 - "Tissue microarrays prepared from 206 undecalcified tumors (71 osteosarcomas, 26 osteoblastomas/osteoid osteomas, 50 giant cell tumors, 5 chondromyxoid fibromas and 54 chondroblastomas) were stained with antibodies to IHH, SP7, SOX9, RUNX2 and TWIST1. " 01/01/2019 - "Immunohistochemical staining with antibodies against H3K36M, trimethylated histones (H3K27me3 and H3K36me3) and an osteoblastic marker (SATB2) was performed on 27 chondroblastomas from 27 patients. " 07/01/2009 - "Archival material from three extraskeletal myxoid chondrosarcomas, five chordomas, five chondromyxoid fibromas, five chondroblastomas and 25 chondrosarcomas was stained with antibodies against osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit) and YKL-40. "
10.	VimentinIBA 02/01/2006 - "In our study of a series of clear cell chondrosarcomas (n = 15) and chondroblastomas (n = 35), S100, vimentin, aggrecan and collagen type II were detected by immunohistochemistry. " 03/01/1990 - "Chondroblastomas were shown to co-express vimentin, S-100 protein, neuron-specific enolase, and the epithelial markers recognized by CAM 5.2, EMA and a polyclonal cytokeratin antibody. " 05/01/1993 - "The observation of positive reaction to S-100 protein (S-100), vimentin (Vim), alpha 1-antichymotrypsin (AACT) and lysozyme (Lyso) by the tumor cells of clear cell chondrosarcoma, similar to traditional chondrosarcoma and chondroblastoma, proves that this tumor has its origin in the cartilaginous tissue. " 07/01/1991 - "The observation of positive reaction to S-100 protein, vimentin, anti-alpha-chymotrypsin and Lysozyme by the tumor cells of clear cell chondrosarcoma, similar to chondrosarcoma and chondroblastoma, proves that this tumor has its origin from the cartilaginous tissue. "

Therapies and Procedures

1.	Curettage 12/01/2002 - "Simple curettage was effective for local control during the initial treatment in most cases, but aggressive curettage and adjuvant treatment with alcohol and/or cement was useful for local control in recurrent chondroblastoma and chondroblastoma presenting with an aggressive behaviour." 11/01/2014 - "Endoscopic curettage is a promising new treatment for chondroblastoma. " 12/01/2022 - "The aim of this study was to determine if RFA is a suitable alternative to curettage with bone graft for the treatment of chondroblastoma. " 04/01/2019 - "This study was performed to describe the epidemiological characteristics and clinical and radiologic results of intralesional curettage of chondroblastoma. " 01/01/2016 - "Results of the current study suggest that intralesion curettage followed by additional burring with an extra-articular approach is a successful treatment option for chondroblastoma of the proximal tibia."
2.	Bone Transplantation (Bone Grafting) 09/01/2013 - "Managing chondroblastoma of the talus with curettage and bone grafting has shown good outcomes. " 08/01/2019 - "Intraregional aggressive curettage, phenolization, and allogeneic bone grafting are effective for treatment of chondroblastoma of the adjoining knee joint." 04/01/2002 - "Endoscopic curettage without bone grafting is a promising new treatment for chondroblastoma." 08/01/2019 - "This retrospective study evaluates the efficacy of intraregional aggressive curettage and allogeneic bone grafting for treating chondroblastoma of the adjoining knee joint. " 06/01/2019 - "A total of 17 patients (ten boys, seven girls; mean age 16.4 years (11 to 26)) diagnosed with chondroblastoma of the femoral head who underwent surgical dislocation of the hip joint, modified trapdoor procedure, curettage, and bone grafting were enrolled in this study and were followed-up for a mean of 35.9 months (12 to 76). "
3.	Radiofrequency Ablation 04/01/2014 - "Radiofrequency ablation appears to be a safe and effective alternative to surgical treatment with a low risk of recurrence and complications for most chondroblastomas. " 11/01/2008 - "The aim of this study is to describe the procedure technique, clinical and imaging outcomes of patients treated with radiofrequency ablation for chondroblastoma. " 12/01/2022 - "Radio Frequency Ablation for the Treatment of Appendicular Skeleton Chondroblastoma: Is It an Excellent Alternative? " 04/01/2015 - "To investigate the long-term clinical and imaging outcomes of patients with chondroblastoma treated by radiofrequency ablation (RFA). " 04/01/2015 - "Radiofrequency ablation of chondroblastoma: long-term clinical and imaging outcomes."
4.	Operative Surgical Procedures 07/01/1979 - "Although most chondroblastomas are cured by limited surgical procedures, occasional lesions behave more aggressively and may even metastasize. " 10/01/2005 - "The patients were treated with different surgical procedures after histologically confirmed chondroblastoma. " 05/12/2016 - "Aggressive chondroblastoma of the distal tibia is rare, and below-knee amputation had been the standard surgical procedure. " 12/01/2009 - "Although most chondroblastomas are cured by limited surgical procedures, occasional lesions behave more aggressively and may even metastasis. " 03/01/2009 - "Other benign conditions (chondroblastoma, osteoblastoma, giant cell tumour, etc.) can also be treated by this technique, which is less invasive than traditional surgical procedures. "
5.	Cryosurgery 05/01/2014 - "Lower recurrence rate in chondroblastoma using extended curettage and cryosurgery." 07/27/2021 - "Percutaneous image-guided cryoablation can be considered potentially safe and effective treatment for chondroblastoma and osteoblastoma in children and adolescents." 07/27/2021 - "To review the safety and efficacy of percutaneous cryoablation for the treatment of chondroblastoma and osteoblastoma in the pediatric and adolescent population. " 07/27/2021 - "A retrospective review from 2016 to 2020 was performed to evaluate clinical and imaging response to percutaneous cryoablation in 11 symptomatic patients with diagnosis of chondroblastoma and osteoblastoma treated from two pediatric hospitals with at least 12-month follow-up. " 07/27/2021 - "Percutaneous cryoablation of chondroblastoma and osteoblastoma in pediatric patients."