Cholinesterase Reactivators

Drugs used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates. They are an important component of therapy in agricultural, industrial, and military poisonings by organophosphates and sulfonates.

Also Known As:

Antagonists, Organophosphate Insecticide; Antagonists, Organothiophosphate Insecticide; Insecticide Antagonists, Organophosphate; Insecticide Antagonists, Organothiophosphate; Reactivators, Cholinesterase; Insecticides, Organophosphate, Antagonists; Insecticides, Organothiophosphate, Antagonists; Organophosphate Insecticide Antagonists; Organothiophosphate Insecticide Antagonists

Networked: 22 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Neurotransmitter Agents: 13181
      - Cholinergic Agents: 12323
        Cholinesterase Reactivators: 22
    - Enzyme Reactivators
      - Cholinesterase Reactivators: 22
  - Physiological Effects of Drugs: 1
    - Neurotransmitter Agents: 13181
      - Cholinergic Agents: 12323
        Cholinesterase Reactivators: 22

Experts

1.	Petroianu, G A: 5 articles (07/2007 - 01/2006)
2.	Nurulain, S M: 4 articles (07/2007 - 05/2006)
3.	Kassa, J: 4 articles (03/2007 - 01/2006)
4.	Kuca, K: 4 articles (03/2007 - 01/2006)
5.	Fusek, Josef: 2 articles (10/2008 - 05/2007)
6.	Jun, Daniel: 2 articles (10/2008 - 05/2007)
7.	Kuca, Kamil: 2 articles (10/2008 - 05/2007)
8.	Hasan, M Y: 2 articles (07/2007 - 01/2007)
9.	Arafat, K: 2 articles (03/2007 - 01/2006)
10.	Nagelkerke, N: 2 articles (01/2007 - 05/2006)

Related Diseases

1.	Poisoning 05/09/1992 - "These results cast doubt on the necessity of cholinesterase reactivators for treatment of acute OP poisoning." 05/01/2007 - "Basic part of the current standard treatment of organophosphate (OP) agent poisoning is administration of cholinesterase reactivators. " 01/01/1969 - "[Late effects upon respiration and circulation following successful treatment of paraoxone poisoning with cholinesterase reactivators and atropine in cats]." 04/15/1959 - "[Poisoning by irreversible cholinesterase inhibitors; cholinesterase reactivators as antidotes]." 05/09/1992 - "Acute organophosphorus (OP) poisoning is usually treated with atropine plus cholinesterase reactivators such as oximes, but controlled trials to assess the efficacy of oximes in OP poisoning have not been done. "
2.	Organophosphate Poisoning 01/01/2017 - "Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning." 07/01/2007 - "Clinical experience with oximes, cholinesterase reactivators used in organophosphorus poisoning, has been disappointing. " 12/28/2006 - "Current understanding of the application of pyridinium oximes as cholinesterase reactivators in treatment of organophosphate poisoning." 05/01/2006 - "Oximes are cholinesterase reactivators used in organophosphorus poisoning. " 10/01/2008 - "The current standard treatment of organophosphate poisoning consists of an administration of anticholinergic drugs and cholinesterase reactivators (oximes). "
3.	Miosis 01/01/1966 - "[Othe suitability of paraoxon miosis of the human eye for testing of cholinesterase reactivators]."
4.	Traumatic Shock 02/01/1973 - "[Traumatic shock and cholinesterase reactivators]."
5.	Shock 01/01/1997 - "Supposedly, obstruction of the smallest vessels with conglomerations is one of the reasons of exotoxic shock development and low efficiency of treatment of carbophos poisoning by means of specific antidotal cholinolytic drugs and cholinesterase reactivators."

Related Drugs and Biologics

1.	Oximes
2.	Atropine
3.	Trimedoxime (Trimedoxime Bromide)
4.	asoxime chloride (H16)
5.	Neostigmine (Neostigmine Bromide)
6.	Cholinergic Antagonists (Anticholinergics)
7.	Organophosphates
8.	Organophosphorus Compounds
9.	Antidotes
10.	pralidoxime (Protopam Chloride)